We show that the glymphatic fluid transporting system contributes to the delivery of choroid plexus/CSF-derived human apoE to neurons. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Research
28,580 Alzheimer's and dementia studies in plain English, each scored out of 100.
Emerging science suggests that aerobic exercise might modify the pathophysiology of Alzheimer's disease (AD) and improve cognition. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
The older patient population is growing rapidly around the world and in the USA. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
38/100
Sleep disturbance is common in patients with dementia. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
A clinically relevant sleep-wake disturbance is found in up to half the patients with dementia, and the sundowning agitation is a common cause of institutionalisation of demented geriatric patients. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Sleep disorders appear to be frequent comorbidities in patients with frontotemporal dementia (FTD). 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
The large majority of neuroimaging studies in Alzheimer's disease (AD) patients have supported the idea that lifestyle factors may protect against the clinical manifestations of AD rather than influence AD neuropathological processes (the cognitive reserve hypothesis). 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
More hallucinatory experiences, social isolation, and loneliness were found in the AD group than in the healthy control group. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
38/100
Benefits of dietary moderation when on a Mediterranean diet type (MD) have been known for well over half a century. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
38/100
Unlike Alzheimer's, vascular dementia can, in part, be prevented. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Dementia, closely linked to environmental predisposing factors such as diet, is a public health problem of increasing magnitude: currently there are more than 35 million patients with Alzheimer´s disease, and is expected to exceed 135 million by 2050. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Alzheimer's disease (AD) is currently the most common incurable forms of dementia. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
There is currently no established therapy to treat or prevent Alzheimer's disease. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
The hippocampus is closely tied to spatial navigation, a central component in cognitive functioning, and critically involved in age-associated cognitive decline and dementia. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Improvements in the aspects evaluated are expected in the IG compared to CG. 1 key finding →
Evidence: high
Full summary, score breakdown and related studies → Original source Full text may need a subscription
37/100
Traumatic brain injury (TBI) alters stress responses, which may influence neuroinflammation and behavioral outcome. 4 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
OF IMPACT: The results contribute new evidence towards an emerging ecological model of cognitive health. 5 key findings →
Participants: 16,404 Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
S/SDOH can significantly impact health throughout the life course by determining access to health promoting resources and opportunities, which in turn impacts modifiable risk factors (e.g., diet, physical activity, social contact) known to influence Alzheimer’s disease and related dementia (ADRD) risk. 5 key findings →
Participants: 111 Evidence: moderate
Full summary, score breakdown and related studies → Original source Full text may need a subscription
Nutrition risk was more common among caregivers when PWD demonstrated nutrition risk. 5 key findings →
Design: cross-sectional Evidence: low
Full summary, score breakdown and related studies → Original source Full text may need a subscription
37/100
The attributes of concepts of social frailty and social isolation overlap, including being alone and having limited or less social activities, engagements or interactions. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
The average MIND-NL scores for the short FFQ (8·4 ( sd 1·8) points) and food records (6·7 ( sd 1·7) points) showed to be significantly different ( P 0·20) were observed for 10 out of 15 MIND-NL diet components. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
These findings suggest that adherence to the MIND diet may support nutrition and psychological well-being in AD and highlight the value of integrating nutrition-based approaches into dementia care. 4 key findings →
Participants: 30 Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
MIND scores were significantly lower in the AD group (P < 0.001). 5 key findings →
Participants: 204 Evidence: low
Full summary, score breakdown and related studies → Original source Full text may need a subscription
Across 58 studies, 38 had an observational design and predominantly used questionnaires to measure cognitive and social activities. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
Fourteen studies were included in the scoping review from 11,492 citations. 5 key findings →
Design: cross-sectional Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
From across this tag
10 of the 1,888 studies in this tag that have a study page, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- Sleep quality and preclinical Alzheimer disease
- Sleep, 24-Hour Activity Rhythms, and Subsequent Amyloid-β Pathology
- Plant-Based Diet Quality, Healthy Lifestyle, and Dementia Risk in Older Adults With Cardiometabolic Diseases
- A randomised controlled trial of physical activity and cognitive training in older adults: the PhABHeaD study
- Dietary Factors and Neurodegenerative Disorders: An Umbrella Review of Meta-Analyses of Prospective Studies
- Alcohol drinking exacerbates neural and behavioral pathology in the 3xTg-AD mouse model of Alzheimer's disease
- Sleep, circadian rhythms, and the pathogenesis of Alzheimer disease
- TNFR-1 and GDF-15 Are Associated With Plasma Neurofilament Light Chain and Progranulin Among Community-Dwelling Older Adults: A Secondary Analysis of the MAPT Study
- Exercise plays a preventive role against Alzheimer's disease
- Sleep Fragmentation and the Risk of Incident Alzheimer's Disease and Cognitive Decline in Older Persons
Where “Free full text” comes from
Free full text links and the Full text may need a subscription label come from Unpaywall, Europe PMC and OpenAlex records of free copies, checked 10 Oct 2026. A study with neither is unknown, not paywalled. Show only studies that are free to read
How the 0–100 score works — and why some entries are capped
This is alzhub's own score. It is not an official metric, not an impact factor, and no journal, publisher or ranking body endorses it. We built it so that a reader who is not a scientist can tell a landmark trial from a conference abstract without having to already know the difference. Every point comes from one of 20 components, all of them printed on the study itself, so you can disagree with our arithmetic rather than having to trust the total.
- Journal tier up to 10 pts
- Journal's citation record up to 4 pts
- Study design up to 12 pts
- Strength of evidence up to 5 pts
- Peer-review validation up to 10 pts
- How recent up to 5 pts
- Sample size up to 4 pts
- Effect reported up to 3 pts
- Studied in people up to 3 pts
- Randomised / blinded up to 2 pts
- Times cited up to 7 pts
- Citations per year up to 5 pts
- Impact for its field and year up to 6 pts
- Cited by studies here up to 6 pts
- Still being cited up to 4 pts
- Senior author's track record up to 4 pts
- Institution's track record up to 3 pts
- Multi-centre collaboration up to 3 pts
- Indexed in PubMed up to 2 pts
- Free to read up to 2 pts
Journals are placed in ordered tiers, never given a numeric impact factor — we could not verify current impact factors from a source we control, and an invented one would be worse than none. Tier 1 is the top-tier general journals (NEJM, The Lancet, JAMA, Nature, Science, Nature Medicine); tier 2 is the leading specialty journals; tier 3 is every other peer-reviewed journal. A separate part scores how much the journal's own papers are cited, which tells the tier-3 journals apart.
Two rules we don't bend. First, we never fill in a missing value: if a record does not state a sample size or a design, that component scores zero, and if we simply have no data for a part, such as a citation count, that part is left out and the study is scored on the parts we could check. The study card says which. Second, anything that is not a peer-reviewed article is capped at 16/100 and carries a warning chip — so a conference abstract or a company press release can never outrank a peer-reviewed paper, no matter how good it looks.
We rank a rigorous null result — a good trial showing that something does not work — above an early positive finding. Someone deciding whether to buy a supplement is served by that, and the rigour is already counted by the design and journal components.
The score is computed from the published data alone and is reproducible: the same file always yields the same numbers.
See the whole rubric drawn out → — four charts covering all 28,580 studies: how the scores are spread and where the cap bites, which of the 20 components the library is strong and weak on, which subjects rest on stronger evidence, and what kinds of study each subject is actually built from.
What this library is — and isn't
This is a large sample of the Alzheimer's literature, not an exhaustive index of it. It holds 28,580 records, built mostly from automated pulls of Europe PMC (62.2% of the library) and OpenAlex (17.8%), plus smaller pulls from PubMed, Crossref and medRxiv. If a study, a drug, or a finding isn't here, that is not evidence it doesn't exist in the literature — it may simply not have been pulled in yet.
1,034 records (3.6% of the library) are not peer-reviewed — 962 of those are preprints posted before any journal review, and the rest are conference abstracts, regulatory notices and reports. Every study card on this page states its status plainly, and the score above is capped for anything that isn't a peer-reviewed article.
See the full, machine-readable breakdown of this library's coverage →