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white-matter
905 studies tagged white-matter, dated 1975-09-01 to 2026-09-14. Bibliography: BibTeX (.bib) · RIS (.ris)
Newest in this topic
- Pathway-specific polygenic risk scores reveal underlying mechanisms of cerebral small vessel disease 2026-09-14
- Cerebral Small Vessel Disease and Risk of Cardiovascular Events and All-Cause Mortality: The Framingham Heart Study 2026-09-07
- Regional Distribution of Mineralized Blood Vessels in Alzheimer Disease and Clinicopathological Associations: A Multicenter Autopsy Study 2026-09-01
Studies
905 studies carry this tag.
Date range
1975 to 2026
Top journals
- Neurology 93
- Stroke 61
- Alzheimer s & Dementia 31
- Brain : a journal of neurology 20
- Annals of neurology 19
342 journals in all.
Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.
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Cerebral small vessel disease (CSVD) is the most common, chronic and progressive vascular disease.
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Further studies are needed to determine whether COVID-19 may lead to an increased risk of developing NDD in susceptible individuals.
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Aging results in gray and white matter degeneration, but the specific microglial responses are unknown.
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Plasma NfL level is a valuable noninvasive biomarker that supplements magnetic resonance imaging scans and possibly reflects the severity of CSVD burden.
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However, some individuals have subtle symptoms associated with acute MRI lesions.
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MRI studies have provided valuable insights into the structure and function of neural networks, particularly in health and in classical neurodegenerative conditions such as Alzheimer disease.
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Loss of physiological microglial function may increase the propagation of neurodegenerative diseases.
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Three women (aged 61, 72, and 73 years) consecutively enrolled in the trial successfully completed repeated focused ultrasound-induced BBB opening of the hippocampus and entorhinal cortex.
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Dysfunction of immune and vascular systems has been implicated in aging and Alzheimer disease; however, their interrelatedness remains poorly understood.
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White matter hyperintensities (WMH) are the most common brain-imaging feature of cerebral small vessel disease (SVD), hypertension being the main known risk factor.
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WMH were associated with increased risk of cognitive dysfunction and could become a neuroimaging indicator of dementia.
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Our results revealed that both TMS and tDCS elicit a small trans-diagnostic effect on working memory, tDCS also improved attention/vigilance across diagnoses.
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MI failed to show an effect on metabolism in FDG-based AD biomarker, but exploratory analysis suggested positive effect on limbic system metabolism.
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56/100
EPVS are related to SVD, also in early disease stages, but the lack of correlation with cognition suggests that their importance is limited.
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Vascular contributions to cognitive impairment and dementia (VCID) are characterized by the aging neurovascular unit being confronted with and failing to cope with biological insults due to systemic and cerebral vascular disease, proteinopathy including Alzheimer's biology, metabolic disease, or immune response, resulting in cognitive decline.
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Apolipoprotein (APOE) e4 genotype is an accepted risk factor for accelerated cognitive aging and dementia, though its neurostructural substrates are unclear.
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Hypertension is one of the main risk factors for vascular dementia and Alzheimer disease.
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Understanding the relationship between infection and stroke has taken on new urgency in the era of the coronavirus disease 2019 (COVID-19) pandemic.
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Healthy cognitive ageing is a societal and public health priority.
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Vascular dementia is the second-most cause of dementia, characterized by cerebral infarcts, white matter lesions, myelin loss and often amyloid angiopathy.
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Age-related chronic inflammatory activation of microglia and their dysfunction are observed in many neurodegenerative diseases, and the potential contributions of these dysfunctional cells to neurodegeneration have been demonstrated recently.
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49/100
The duration and lifetime pattern of hypertension is related to risk of stroke and dementia.
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The diverse leukocyte infiltrate in atherosclerotic mouse aortas was recently analyzed in 9 single-cell RNA sequencing and 2 mass cytometry studies.
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Hypertension is a leading cause of stroke and dementia, effects attributed to disrupting delivery of blood flow to the brain.
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Broad clinical syndromes associated with COVID-19 were classified as a cerebrovascular event (defined as an acute ischaemic, haemorrhagic, or thrombotic vascular event involving the brain parenchyma or subarachnoid space), altered mental status (defined as an acute alteration in personality, behaviour, cognition, or consciousness), peripheral neurology (defined as involving nerve roots, peripheral nerves, neuromuscular junction, or muscle), or other (with free text boxes for those not meeting these syndromic presentations).
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Exposure to ambient air pollution is a well-established determinant of health and disease.
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Periventricular white matter hyperintensities (WMH; PVWMH) and deep WMH (DWMH) are regional classifications of WMH and reflect proposed differences in cause.
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Traditional neuroimage analysis pipelines involve computationally intensive, time-consuming optimization steps, and thus, do not scale well to large cohort studies with thousands or tens of thousands of individuals.
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The present study examines functional contributions of microglia in host defense, demyelination, and remyelination following infection of susceptible mice with a neurotropic coronavirus.
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62/100
Cerebral small vessel disease is a major cause of stroke and dementia, but its genetic basis is incompletely understood.
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This manuscript is the second part of a two-part description of the current status of understanding of the network function of the brain in health and disease.
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37/100
Traumatic brain injury (TBI) alters stress responses, which may influence neuroinflammation and behavioral outcome.
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Pericytes are unique, multi-functional mural cells localized at the abluminal side of the perivascular space in microvessels.
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41/100
Future experiments and validation studies Future research should determine the extent to which prevention of surgery-induced microgliosis and/or neurovascular unit dysfunction can prevent or ameliorate postoperative memory and attention deficits in animal models.
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Accumulating evidence suggests that inflammation is a major contributor in the pathogenesis of several highly prevalent, but also rare, neurological diseases.
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Sepsis is a major cause of death in intensive care units worldwide.
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Adults with type 2 diabetes are at an increased risk of developing certain brain or mental disorders, including stroke, dementia, and depression.
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Chronic traumatic encephalopathy (CTE) is a neurodegenerative tauopathy associated with repeated subconcussive and concussive head injury.
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Perivascular spaces include a variety of passageways around arterioles, capillaries and venules in the brain, along which a range of substances can move.
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The blood-brain barrier (BBB) is a complex and dynamic physiological interface between brain parenchyma and cerebral vasculature.
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Cigarette smoking is associated with increased risk for myriad health consequences including cognitive decline and dementia, but research on the link between smoking and brain structure is nascent.
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Midlife vascular risk burden is associated with late-life dementia.
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51/100
Approximately 10% of dementia patients have idiopathic normal pressure hydrocephalus (iNPH), an expansion of the cerebrospinal fluid (CSF)-filled brain ventricles. iNPH and Alzheimer's disease (AD) both exhibit sleep disturbances, build-up of brain metabolic wastes and amyloid-β (Aβ) plaques, perivascular reactive astrogliosis, and mislocalization of astrocyte aquaporin-4 (AQP4).
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Insomnia in cognitively unimpaired adults at increased risk for AD is associated to poorer performance in some executive functions and volume changes in cortical and subcortical gray matter, including key areas involved in Alzheimer's disease, as well as decreased white matter diffusivity.
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Changes in the properties of DTI may be the potential mechanism of WMH-related MCI, especially the right IFOF and the right ILF, which may become imaging markers for predicting WMH-related cognitive dysfunction.
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White matter hyperintensities (WMHs), mainly caused by cerebrovascular injury, may lead to cognitive impairment.
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This untargeted metabolomics study identified potential biomarkers for cognitive function in a cohort of Puerto Rican older adults.
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Microglial activation participates in white matter injury after cerebral hypoperfusion.
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Cerebrovascular diseases are well established causes of cognitive impairment.
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While delirium is associated with cognitive decline and dementia, there is limited evidence to support causality for this relationship.
From across this tag
8 of the 904 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 8. The same 8 appear here every time.
- Type 2 diabetes and atrophy of medial temporal lobe structures on brain MRI
- The hemo-neural hypothesis: on the role of blood flow in information processing
- The Role of Oxidative Stress and Inflammation in the Pathogenesis and Treatment of Vascular Dementia
- Fluid Biomarkers of Cognitive Impairments Following Traumatic Brain Injury: A Systematic Review and Meta Analysis
- Crucial role of microglia-mediated myelin sheath damage in vascular dementia: Antecedents and consequences
- Blood-Brain Barrier Disruption Is an Early Event That May Persist for Many Years After Traumatic Brain Injury in Humans
- Atrophy patterns in cerebral amyloid angiopathy with and without cortical superficial siderosis
- Neuroimaging correlates of HIV-associated BBB compromise