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Home › Research › Topic

Brain proteins, microglia and lab models

4,766 studies in this group. A computer grouped them by what their titles and summaries are about, not by a hand-made list. The name describes most of the group, not every study in it.

Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.

Highest usefulness score first. Studies without a score come last.

  1. Obesity, diabetes, and leptin resistance promote tau pathology in a mouse model of disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neuroscience 2015-12-14 Disease mechanisms

    Obesity and type 2 diabetes mellitus (T2DM) convey an increased risk for developing dementia.

  2. Prion Diseases

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Continuum (Minneapolis, Minn.) 2015-12-01 Disease mechanisms

    This article presents an update on the clinical aspects of human prion disease, including the wide spectrum of their presentations.

  3. Glial fibrillar acidic protein in the cerebrospinal fluid of Alzheimer's disease, dementia with Lewy bodies, and frontotemporal lobar degeneration

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of neurochemistry 2015-11-11 Inflammation and the immune system

    Biomarkers in the cerebrospinal fluid (CSF) are currently regarded as indispensable indicators for accurate differential diagnosis of neurodegenerative disorders.

  4. Reversal effects of crocin on amyloid β-induced memory deficit: Modification of autophagy or apoptosis markers

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Pharmacology, biochemistry, and behavior 2015-10-17 Disease mechanisms

    Crocin, as a carotenoid, is one of the main and active constituents of saffron stigmas (Crocus sativus L.) that is widely used in folk medicine.

  5. Astrocytic estrogen receptors and impaired neurotrophic responses in a rat model of perimenopause

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Frontiers in aging neuroscience 2015-09-29 Biomarkers

    In a perimenopausal model of middle-aged rats, the astrocyte estrogen receptor-alpha (ERa): ER-beta (ERb) ratio increased with the onset of acyclicity (constant estrus, CE) in association with impaired neurotrophic responses to estradiol (E2).

    Why it matters

    In a rat model of perimenopause, changes in astrocyte estrogen receptors were linked to impaired responses to estradiol, which the authors relate to perimenopausal factors and higher Alzheimer risk in women. This is animal research and does not show any treatment, cure, or prevention for Alzheimer's disease.

  6. Appoptosin-Mediated Caspase Cleavage of Tau Contributes to Progressive Supranuclear Palsy Pathogenesis

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neuron 2015-09-01 Disease mechanisms

    Progressive supranuclear palsy (PSP) is a movement disorder characterized by tau neuropathology where the underlying mechanism is unknown.

  7. Hippocampal volume and functional connectivity changes during the female menstrual cycle

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. NeuroImage 2015-06-06 Hippocampus size on brain scans

    Hippocampal volume has been shown to be sensitive to variations in estrogen and progesterone levels across rodents' estrous cycle.

  8. Sevoflurane and Isoflurane induce structural changes in brain vascular endothelial cells and increase blood-brain barrier permeability: Possible link to postoperative delirium and cognitive decline

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Brain research 2015-05-08 Clinical safety

    A large percentage of patients subjected to general anesthesia at 65 years and older exhibit postoperative delirium (POD).

  9. A computational atlas of the hippocampal formation using ex vivo, ultra-high resolution MRI: Application to adaptive segmentation of in vivo MRI

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. NeuroImage 2015-04-29 Hippocampus size on brain scans

    Automated analysis of MRI data of the subregions of the hippocampus requires computational atlases built at a higher resolution than those that are typically used in current neuroimaging studies.

  10. Sleep deprivation and hippocampal vulnerability: changes in neuronal plasticity, neurogenesis and cognitive function

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neuroscience 2015-04-29 Hippocampus size on brain scans

    Despite the ongoing fundamental controversy about the physiological function of sleep, there is general consensus that sleep benefits neuronal plasticity, which ultimately supports brain function and cognition.

  11. Brain morphology links systemic inflammation to cognitive function in midlife adults

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Brain, behavior, and immunity 2015-04-14 Hippocampus size on brain scans

    Inflammation and adiposity might relate to cognitive decline via influences on brain morphology.

  12. Pathological tau disrupts ongoing network activity

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neuron 2015-02-19 Disease mechanisms

    Pathological tau leads to dementia and neurodegeneration in tauopathies, including Alzheimer's disease.

  13. Myoclonic epilepsy in Down syndrome and Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neurologia (Barcelona, Spain) 2015-02-07 Down syndrome and Alzheimer's

    The association of generalized epilepsy with elderly DS represents an epiphenomenon in evolution which is associated with a progressive deterioration of cognitive and motor functions.

    Why it matters

    This case series of 11 patients with Down syndrome or Alzheimer's disease describes myoclonic epilepsy that appeared with age and was followed by faster cognitive decline. Levetiracetam was the most effective drug in this series, but this is a small observational report and does not show that treating seizures prevents or cures Alzheimer's disease.

  14. The flavonoid quercetin ameliorates Alzheimer's disease pathology and protects cognitive and emotional function in aged triple transgenic Alzheimer's disease model mice

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neuropharmacology 2015-02-07 Disease mechanisms

    Alzheimer's disease (AD) is the most common senile dementia in the world.

  15. Disrupted hippocampal sharp-wave ripple-associated spike dynamics in a transgenic mouse model of dementia

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The Journal of physiology 2015-01-02 Disease mechanisms

    Key points High frequency (100-250 Hz) neuronal oscillations in the hippocampus, known as sharp-wave ripples (SWRs), synchronise the firing behaviour of groups of neurons and play a key role in memory consolidation.

  16. String Vessel Formation is Increased in the Brain of Parkinson Disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of Parkinson's disease 2015-01-01 Biomarkers

    Endothelial degeneration and preservation of basement membrane result in an increase of string vessel formation in PD.

    Why it matters

    In human Parkinson disease brain tissue, string vessel density was significantly increased, especially in the substantia nigra, while basement-membrane-associated vessel density was similar to controls. This describes a vascular change in Parkinson disease and does not report a treatment or prevention effect for Alzheimer's disease.

  17. Helicobacter pylori filtrate induces Alzheimer-like tau hyperphosphorylation by activating glycogen synthase kinase-3β

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of Alzheimer's disease : JAD 2015-01-01 Disease mechanisms

    Abnormal hyperphosphorylation of microtubule-associated protein tau is involved in the pathogenesis of several neurodegenerative disorders including Alzheimer's disease (AD).

  18. A novel, ultrasensitive assay for tau: potential for assessing traumatic brain injury in tissues and biofluids

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of neurotrauma 2014-12-23 Disease mechanisms

    Traumatic brain injury (TBI) is a cause of death and disability and can lead to tauopathy-related dementia at an early age.

  19. Effects of Physical Exercise on Neuroinflammation, Neuroplasticity, Neurodegeneration, and Behavior: What We Can Learn From Animal Models in Clinical Settings

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neurorehabilitation and neural repair 2014-12-19 Inflammation and the immune system

    Physical exercise is a cornerstone in the management of many neurodegenerative disorders, such as Parkinson's disease, dementia, and stroke.

  20. From chronic cerebral hypoperfusion to Alzheimer-like brain pathology and neurodegeneration

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Cellular and molecular neurobiology 2014-10-29 Inflammation and the immune system

    Chronic cerebral hypoperfusion (CCH) is a common consequence of various cerebral vascular disorders and hemodynamic and blood changes.

  21. Multi-faced neuroprotective effects of geniposide depending on the RAGE-mediated signaling in an Alzheimer mouse model

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neuropharmacology 2014-09-28 Disease mechanisms

    The receptor for advanced glycation end products (RAGE)-mediated signaling pathway is related to Aβ-induced pathogenic responses.

  22. Dendritic spinopathy in transgenic mice expressing ALS/dementia-linked mutant UBQLN2

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Proceedings of the National Academy of Sciences of the United States of America 2014-09-22 Disease mechanisms

    Mutations in the gene encoding ubiquilin2 (UBQLN2) cause amyotrophic lateral sclerosis (ALS), frontotemporal type of dementia, or both.

  23. Deficiency in LRP6-mediated Wnt signaling contributes to synaptic abnormalities and amyloid pathology in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neuron 2014-09-18 Disease mechanisms

    Alzheimer's disease (AD) is an age-related neurological disorder characterized by synaptic loss and dementia.

  24. The role of hippocampal tau protein phosphorylation in isoflurane-induced cognitive dysfunction in transgenic APP695 mice

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Anesthesia and analgesia 2014-08-01 Tau biomarkers

    Previous studies have shown that exposure to inhaled anesthetics can cause cognitive dysfunction, suggesting that general anesthesia might be a risk factor for the development of Alzheimer disease.

    Why it matters

    In a mouse model of Alzheimer's disease, isoflurane anesthesia was linked to cognitive problems and increased tau phosphorylation in the hippocampus. This is animal research about a possible mechanism and does not show that anesthesia causes Alzheimer's in people or that any treatment prevents it.

  25. Hippocampal atrophy in major depression: a function of childhood maltreatment rather than diagnosis?

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2014-06-13 Hippocampus size on brain scans

    Reduced hippocampal volumes are probably the most frequently reported structural neuroimaging finding associated with major depressive disorder (MDD).

From across this topic

10 of the 4,748 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.

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