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Home › Research › Topics › synaptic

synaptic

288 studies tagged synaptic, dated 1983-02-20 to 2026-10-29. Bibliography: BibTeX (.bib) · RIS (.ris)

Newest in this topic

  1. Aβ42 oligomers disrupt calcium homeostasis via Piezo1 and induce neurotoxicity in differentiated SH-SY5Y cells 2026-10-29
  2. Endocannabinnoids innervate Circadian mechinary mitigating neuroinflammation, amyloidogenesis and cognition phenotypic to AD 2026-10-29
  3. Repeated VU0155069 Treatment Is Associated with Region- and Pathological Stage-Specific Dendritic Spine Remodeling in Female 3xTg-AD Mice 2026-10-27

Studies

288 studies carry this tag.

Date range

1983 to 2026

Top journals

  • The Journal of neuroscience : the official journal of the Society for Neuroscience 17
  • Nature neuroscience 10
  • Neuron 10
  • bioRxiv 10
  • Nature 8

137 journals in all.

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

  1. Muscone Ameliorates Synaptic Dysfunction and Cognitive Deficits in APP/PS1 Mice

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Journal of Alzheimer's disease : JAD 2020 Disease mechanisms

    Mus treatment attenuated memory dysfunction, reduced Aβ level, and enhanced synaptic plasticity in APP/PS1 mice.

  2. Modified Glutamatergic Postsynapse in Neurodegenerative Disorders

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Neuroscience 2019-12-27 Disease mechanisms

    The postsynaptic density (PSD) is a complex subcellular domain important for postsynaptic signaling, function, and plasticity.

  3. Targeting Synaptic Plasticity in Experimental Models of Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Frontiers in pharmacology 2019-07-16 Disease mechanisms

    Long-term potentiation (LTP) and long-term depression (LTD) of hippocampal synaptic transmission represent the principal experimental models underlying learning and memory.

  4. Multi-sensory Gamma Stimulation Ameliorates Alzheimer's-Associated Pathology and Improves Cognition

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Cell 2019-03-14 Inflammation and the immune system

    We previously reported that inducing gamma oscillations with a non-invasive light flicker (gamma entrainment using sensory stimulus or GENUS) impacted pathology in the visual cortex of Alzheimer's disease mouse models.

  5. The Role of NMDA Receptors in Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Frontiers in neuroscience 2019-02-08 Treatments

    In Alzheimer's disease (AD), early synaptic dysfunction is associated with the increased oligomeric amyloid-beta peptide, which causes NMDAR-dependent synaptic depression and spine elimination.

  6. Astrocyte function from information processing to cognition and cognitive impairment

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Nature neuroscience 2019-01-21 Risk factors

    Astrocytes serve important roles that affect recruitment and function of neurons at the local and network levels.

  7. Dendritic spines: Revisiting the physiological role

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Progress in neuro-psychopharmacology & biological psychiatry 2019-01-15 Disease mechanisms

    Dendritic spines are small, thin, specialized protrusions from neuronal dendrites, primarily localized in the excitatory synapses.

  8. Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer's models

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Nature medicine 2019-01-07 Tau biomarkers

    Defective brain hormonal signaling has been associated with Alzheimer's disease (AD), a disorder characterized by synapse and memory failure.

  9. Changes in Synaptic Proteins Precede Neurodegeneration Markers in Preclinical Alzheimer's Disease Cerebrospinal Fluid

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Molecular & Cellular Proteomics 2019-01-03 Genetics

    In BriefIn the search for biomarkers of synapse loss associated with Alzheimer's disease (AD), we used shotgun proteomics to identify a panel of 9 synaptic proteins detectable in human cerebrospinal fluid (CSF).Expression at the human synapse was verified using super resolution microscopy.

  10. Noradrenergic Regulation of Hippocampus-Dependent Memory

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Central nervous system agents in medicinal chemistry 2019 Disease mechanisms

    Neuromodulation regulates critical functions of CNS synapses, ranging from neural circuit development to high-order cognitive processes, including learning and memory.

  11. Alzheimer's Disease Risk Factor Pyk2 Mediates Amyloid-β-Induced Synaptic Dysfunction and Loss

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. The Journal of neuroscience : the official journal of the Society for Neuroscience 2018-12-05 Disease mechanisms

    Dozens of genes have been implicated in late onset Alzheimer's disease (AD) risk, but none has a defined mechanism of action in neurons.

  12. DYRK1A and cognition: A lifelong relationship

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Pharmacology & therapeutics 2018-09-28 Down syndrome and Alzheimer's

    The dosage of the serine threonine kinase DYRK1A is critical in the central nervous system (CNS) during development and aging.

  13. Thiamine deficiency contributes to synapse and neural circuit defects

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Biological research 2018-09-19 Disease mechanisms

    To demonstrate this hypothesis, we established abnormalities in the glucose metabolism utilizing thiamine deficiency in vitro and in vivo, and we found dramatically reduced dendrite spine density.

  14. Riluzole reduces amyloid beta pathology, improves memory, and restores gene expression changes in a transgenic mouse model of early-onset Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Translational psychiatry 2018-08-14 Biomarkers

    Alzheimer's disease (AD) represents a major healthcare burden with no effective treatment.

  15. miRNA-34c Overexpression Causes Dendritic Loss and Memory Decline

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. International journal of molecular sciences 2018-08-08 Disease mechanisms

    Microribonucleic acids (miRNAs) play a pivotal role in numerous aspects of the nervous system and are increasingly recognized as key regulators in neurodegenerative diseases.

  16. Klotho at the Edge of Alzheimer's Disease and Senile Depression

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Molecular neurobiology 2018-07-05 Risk factors

    Klotho, encoded by the KL gene, is a single-pass transmembrane protein and a circulating factor that plays a key role in cellular metabolism and body homeostasis and has been associated with age-related diseases.

  17. CaMKII Metaplasticity Drives Aβ Oligomer-Mediated Synaptotoxicity

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Cell reports 2018-06-12 Disease mechanisms

    Alzheimer's disease (AD) is emerging as a synaptopathology driven by metaplasticity.

  18. Spatial reversal learning defect coincides with hypersynchronous telencephalic BOLD functional connectivity in APP NL-F/NL-F knock-in mice

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Scientific reports 2018-04-19 Biomarkers

    Amyloid pathology occurs early in Alzheimer's disease (AD), and has therefore been the focus of numerous studies.

  19. Pin1 mediates Aβ42-induced dendritic spine loss

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Science signaling 2018-03-20 Disease mechanisms

    Early-stage Alzheimer's disease is characterized by the loss of dendritic spines in the neocortex of the brain.

  20. Synaptic plasticity modulation by circulating peptides and metaplasticity: Involvement in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Pharmacological research 2018-02-06 Disease mechanisms

    Synaptic plasticity is a cellular process involved in learning and memory whose alteration in its two main forms (Long Term Depression (LTD) and Long Term Potentiation (LTP)), is observed in most brain pathologies, including neurodegenerative disorders such as Alzheimer's disease (AD).

  21. The relationship between stress and Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Neurobiology of stress 2018-02-01 Health systems and care delivery

    Stress is critically involved in the development and progression of disease.

  22. Wnt signaling loss accelerates the appearance of neuropathological hallmarks of Alzheimer's disease in J20-APP transgenic and wild-type mice

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Journal of neurochemistry 2018-01-26 Biomarkers

    Alzheimer's disease (AD) is a neurodegenerative pathology characterized by aggregates of amyloid-β (Aβ) and phosphorylated tau protein, synaptic dysfunction, and spatial memory impairment.

  23. Differences in Synaptic Dysfunction Between rTg4510 and APP/PS1 Mouse Models of Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Journal of Alzheimer's disease : JAD 2018 Disease mechanisms

    Genetically modified mice have provided insights into the progression and pathology of Alzheimer's disease (AD).

  24. Metformin treatment prevents amyloid plaque deposition and memory impairment in APP/PS1 mice

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Brain, behavior, and immunity 2017-12-15 Drug development

    Alzheimer'sdisease(AD) is characterized by deposition of amyloid-β (Aβ)plaques, neurofibrillary tangles, andneuronal loss, accompaniedbyneuroinflammation.

  25. Near infrared light decreases synaptic vulnerability to amyloid beta oligomers

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Scientific reports 2017-11-08 Disease mechanisms

    Synaptic dysfunction due to the disrupting binding of amyloid beta (Aβ) and tau oligomers is one of the earliest impairments in Alzheimer's Disease (AD), driving initial cognitive deficits and clinical manifestation.

  26. CRISPR/Cas9-Correctable mutation-related molecular and physiological phenotypes in iPSC-derived Alzheimer's PSEN2 N141I neurons

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Acta neuropathologica communications 2017-10-27 Biomarkers

    Basal forebrain cholinergic neurons (BFCNs) are believed to be one of the first cell types to be affected in all forms of AD, and their dysfunction is clinically correlated with impaired short-term memory formation and retrieval.

  27. Neuroprotective Actions of Dietary Choline

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Nutrients 2017-07-28 Genetics

    Choline is an essential nutrient for humans.

  28. Necroptosis activation in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Nature neuroscience 2017-07-24 Genetics

    Alzheimer's disease (AD) is characterized by severe neuronal loss; however, the mechanisms by which neurons die remain elusive.

  29. Amyloid-β Peptide Is Needed for cGMP-Induced Long-Term Potentiation and Memory

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. The Journal of neuroscience : the official journal of the Society for Neuroscience 2017-06-16 Disease mechanisms

    High levels of amyloid-β peptide (Aβ) have been related to Alzheimer's disease pathogenesis.

  30. Regulation of postsynaptic signaling in structural synaptic plasticity

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Current opinion in neurobiology 2017-06-07 Disease mechanisms

    Morphological changes of dendritic spines are strongly associated with synaptic development and synaptic plasticity, which underlies learning and memory.

  31. Netrin-1 improves the amyloid-β-mediated suppression of memory and synaptic plasticity

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Brain research bulletin 2017-04-04 Disease mechanisms

    The aim of this study was to investigate the effects of netrin-1 (NT-1) on amyloid-beta (Aβ)-induced impairments in learning-memory and synaptic plasticity.

  32. Dopamine neuronal loss contributes to memory and reward dysfunction in a model of Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Nature communications 2017-04-03 Disease mechanisms

    Alterations of the dopaminergic (DAergic) system are frequently reported in Alzheimer's disease (AD) patients and are commonly linked to cognitive and non-cognitive symptoms.

  33. Aberrant iPSC-derived human astrocytes in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Cell Death and Disease 2017-03-23 Biomarkers

    The pathological potential of human astroglia in Alzheimer's disease (AD) was analysed in vitro using induced pluripotent stem cell (iPSC) technology.

  34. Astrocytes and synaptic plasticity in health and disease

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Experimental brain research 2017-03-15 Disease mechanisms

    Activity-dependent synaptic plasticity phenomena such as long-term potentiation and long-term depression are candidate mechanisms for storing information in the brain.

  35. Human astrocytes in the diseased brain

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Brain research bulletin 2017-02-13 Down syndrome and Alzheimer's

    Astrocytes are key active elements of the brain that contribute to information processing.

  36. Regulation of Cognitive Processing by Hippocampal Cholinergic Tone

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Cerebral cortex (New York, N.Y. : 1991) 2017-02-01 Disease mechanisms

    Cholinergic dysfunction has been associated with cognitive abnormalities in a variety of neurodegenerative and neuropsychiatric diseases.

  37. Tunicamycin impairs olfactory learning and synaptic plasticity in the olfactory bulb

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Neuroscience 2017-01-11 Disease mechanisms

    Tunicamycin (TM) induces endoplasmic reticulum (ER) stress and inhibits N-glycosylation in cells.

  38. Calcium Hypothesis of Alzheimer's disease and brain aging: A framework for integrating new evidence into a comprehensive theory of pathogenesis

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Alzheimer's & dementia : the journal of the Alzheimer's Association 2017-01-03 Brain scans and imaging

    This article updates the Calcium Hypothesis of Alzheimer's disease and brain aging on the basis of emerging evidence since 1994 (The present article, with the subtitle "New evidence for a central role of Ca 2+ in neurodegeneration," includes three appendices that provide context and further explanations for the rationale for the revisions in the updated hypothesis-the three appendices are as follows: Appendix I "Emerging concepts on potential pathogenic roles of [Ca 2+ ]," Appendix II "Future studies to validate the central role of dysregulated [Ca 2+ ] in neurodegeneration," and Appendix III "Epilogue: towards a comprehensive hypothesis.")

  39. Drebrin in Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Advances in experimental medicine and biology 2017 Disease mechanisms

    Alzheimer's disease (AD) is a neurodegenerative disorder accompanied by severe progressive memory and cognitive impairment.

  40. Role of Glutamate and NMDA Receptors in Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Journal of Alzheimer's disease : JAD 2017-01-01 Treatments

    Excitatory glutamatergic neurotransmission via N-methyl-d-aspartate receptor (NMDAR) is critical for synaptic plasticity and survival of neurons.

  41. Role of the adhesion molecule F3/Contactin in synaptic plasticity and memory

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Molecular and cellular neurosciences 2016-12-28 Disease mechanisms

    Cell adhesion molecules (CAMs) have a pivotal role in building and maintaining synaptic structures during brain development participating in axonal elongation and pathfinding, glial guidance of neuronal migration, as well as myelination.

  42. Gamma frequency entrainment attenuates amyloid load and modifies microglia

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Nature 2016-12-01 Inflammation and the immune system

    Changes in gamma oscillations (20-50 Hz) have been observed in several neurological disorders.

  43. Casting a Wide Net: Role of Perineuronal Nets in Neural Plasticity

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The Journal of neuroscience : the official journal of the Society for Neuroscience 2016-11-01 Risk factors

    Perineuronal nets (PNNs) are unique extracellular matrix structures that wrap around certain neurons in the CNS during development and control plasticity in the adult CNS.

  44. Amyloid beta modulators and neuroprotection in Alzheimer's disease: a critical appraisal

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Drug discovery today 2016-10-27 Disease mechanisms

    Multiple cellular changes have been identified as being involved in Alzheimer's disease (AD) pathogenesis, including mitochondrial damage, synaptic loss, amyloid beta (Aβ) production and/or accumulation, inflammatory responses, and phosphorylated tau formation and/or accumulation.

  45. Ginkgolic Acid Protects against Aβ-Induced Synaptic Dysfunction in the Hippocampus

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Frontiers in pharmacology 2016-10-26 Disease mechanisms

    Ginkgo leaf is the most used form of supplement for cognitive ailments.

  46. Targeting SUMO-1ylation Contrasts Synaptic Dysfunction in a Mouse Model of Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Molecular neurobiology 2016-10-13 Disease mechanisms

    Synaptic dysfunction has been recognized as an early feature occurring at the onset of Alzheimer's disease (AD).

  47. Imaging synaptic density in the living human brain

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Science translational medicine 2016-07-01 Disease mechanisms

    Chemical synapses are the predominant neuron-to-neuron contact in the central nervous system.

  48. Memory retrieval by activating engram cells in mouse models of early Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Nature 2016-03-16 Disease mechanisms

    Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive memory decline and subsequent loss of broader cognitive functions.

  49. Dysfunction of NMDA receptors in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 2016-03-12 Disease mechanisms

    N-methyl-D-aspartate receptors (NMDARs) play a pivotal role in the synaptic transmission and synaptic plasticity thought to underlie learning and memory.

  50. Emerging Link between Alzheimer's Disease and Homeostatic Synaptic Plasticity

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Neural plasticity 2016-02-25 Disease mechanisms

    Alzheimer's disease (AD) is an irreversible brain disorder characterized by progressive cognitive decline and neurodegeneration of brain regions that are crucial for learning and memory.

From across this tag

7 of the 288 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 7. The same 7 appear here every time.

All topic tags with their study counts