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Home › Research › Topics › synaptic

synaptic

288 studies tagged synaptic, dated 1983-02-20 to 2026-10-29. Bibliography: BibTeX (.bib) · RIS (.ris)

Newest in this topic

  1. Aβ42 oligomers disrupt calcium homeostasis via Piezo1 and induce neurotoxicity in differentiated SH-SY5Y cells 2026-10-29
  2. Endocannabinnoids innervate Circadian mechinary mitigating neuroinflammation, amyloidogenesis and cognition phenotypic to AD 2026-10-29
  3. Repeated VU0155069 Treatment Is Associated with Region- and Pathological Stage-Specific Dendritic Spine Remodeling in Female 3xTg-AD Mice 2026-10-27

Studies

288 studies carry this tag.

Date range

1983 to 2026

Top journals

  • The Journal of neuroscience : the official journal of the Society for Neuroscience 17
  • Nature neuroscience 10
  • Neuron 10
  • bioRxiv 10
  • Nature 8

137 journals in all.

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

  1. BDNF and 5-HT: a dynamic duo in age-related neuronal plasticity and neurodegenerative disorders

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Trends in neurosciences 2004-10-01 Risk factors

    Brain-derived neurotrophic factor (BDNF) and serotonin (5-hydroxytryptamine, 5-HT) are known to regulate synaptic plasticity, neurogenesis and neuronal survival in the adult brain.

  2. Deciphering the molecular basis of memory failure in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neuron 2004-09-01 Disease mechanisms

    Acutely developing lesions of the brain have been highly instructive in elucidating the neural systems underlying memory in humans and animal models.

  3. Docosahexaenoic acid protects from dendritic pathology in an Alzheimer's disease mouse model

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neuron 2004-09-01 Prevention and risk

    Learning and memory depend on dendritic spine actin assembly and docosahexaenoic acid (DHA), an essential n-3 (omega-3) polyunsaturated fatty acid (PFA).

  4. HIV secreted protein Tat prevents long-term potentiation in the hippocampal CA1 region

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Brain research 2004-06-25 Disease mechanisms

    HIV-associated dementia (HAD) is a complication of advanced HIV disease.

  5. Glycogen synthase kinase 3: a drug target for CNS therapies

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of neurochemistry 2004-06-01 Drug development

    Glycogen synthase kinase3 (GSK3) is emerging as a prominent drug target in the CNS.

  6. Lithium, a common drug for bipolar disorder treatment, regulates amyloid-beta precursor protein processing

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Biochemistry 2004-06-01 Drug development

    Lithium is one of the most widely used mood-stabilizing agents for the treatment of bipolar disorder.

  7. Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neuron 2004-04-01 Risk genes beyond APOE

    Mutations in presenilins are the major cause of familial Alzheimer's disease, but the pathogenic mechanism by which presenilin mutations cause memory loss and neurodegeneration remains unclear.

  8. Age-related myelin breakdown: a developmental model of cognitive decline and Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neurobiology of aging 2004-01-01 Risk factors

    The ensuing homeostatic responses to myelin breakdown further increase intracortical toxicity and results in the relentless progression and non-random anatomical distribution of AD lesions that eventually cause neuronal dysfunction and degeneration.

  9. APP processing and synaptic function

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neuron 2003-03-01 Risk genes beyond APOE

    A large body of evidence has implicated Abeta peptides and other derivatives of the amyloid precursor protein (APP) as central to the pathogenesis of Alzheimer's disease (AD).

  10. Activation of Wnt signaling rescues neurodegeneration and behavioral impairments induced by beta-amyloid fibrils

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Molecular psychiatry 2003-02-01 Drug development

    Alzheimer's disease (AD) is a progressive neurodegenerative disorder, which is probably caused by the cytotoxic effect of the amyloid beta-peptide (Abeta).

  11. Neuroprotection by memantine against neurodegeneration induced by beta-amyloid(1-40)

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Brain research 2002-12-01 Biomarkers

    Progressive neuronal loss and cognitive decline in Alzheimer's disease (AD) might be aggravated by beta-amyloid-enhanced excitotoxicity.

  12. Amyloid beta -peptide inhibition of the PKA/CREB pathway and long-term potentiation: reversibility by drugs that enhance cAMP signaling

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Proceedings of the National Academy of Sciences of the United States of America 2002-09-20 Disease mechanisms

    Changes in hippocampal function seem critical for cognitive impairment in Alzheimer's disease (AD).

  13. Dendritic spine pathology: cause or consequence of neurological disorders?

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Brain research. Brain research reviews 2002-06-01 Prevention and risk

    Altered dendritic spines are characteristic of traumatized or diseased brain.

  14. Estrogen actions throughout the brain

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Recent progress in hormone research 2002-01-01 Disease mechanisms

    Besides affecting the hypothalamus and other brain areas related to reproduction, ovarian steroids have widespread effects throughout the brain, on serotonin pathways, catecholaminergic neurons, and the basal forebrain cholinergic system as well as the hippocampal formation, a brain region involved in spatial and declarative memory.

  15. Soluble oligomers of beta amyloid (1-42) inhibit long-term potentiation but not long-term depression in rat dentate gyrus

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Brain research 2002-01-01 Risk factors

    The dementia in Alzheimer disease (AD) is usually attributed to widespread neuronal loss in conjunction with the pathologic hallmarks of intracellular neurofibrillary tangles and extracellular plaques containing amyloid (A beta) in fibrillar form.

  16. Invited review: Estrogens effects on the brain: multiple sites and molecular mechanisms

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of applied physiology (Bethesda, Md. : 1985) 2001-12-01 Disease mechanisms

    Besides their well-established actions on reproductive functions, estrogens exert a variety of actions on many regions of the nervous system that influence higher cognitive function, pain mechanisms, fine motor skills, mood, and susceptibility to seizures; they also appear to have neuroprotective actions in relation to stroke damage and Alzheimer's disease.

  17. The multifaceted roles of glycogen synthase kinase 3beta in cellular signaling

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Progress in neurobiology 2001-11-01 Risk genes beyond APOE

    Glycogen synthase kinase-3beta (GSK3beta) is a fascinating enzyme with an astoundingly diverse number of actions in intracellular signaling systems.

  18. Glutamate uptake

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Progress in neurobiology 2001-09-01 Inflammation and the immune system

    Brain tissue has a remarkable ability to accumulate glutamate.

  19. Beta-amyloid activates the mitogen-activated protein kinase cascade via hippocampal alpha7 nicotinic acetylcholine receptors: In vitro and in vivo mechanisms related to Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The Journal of neuroscience : the official journal of the Society for Neuroscience 2001-06-01 Disease mechanisms

    Alzheimer's Disease (AD) is the most common of the senile dementias, the prevalence of which is increasing rapidly, with a projected 14 million affected worldwide by 2025.

  20. Altered expression of synaptic proteins occurs early during progression of Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Neurology 2001-01-01 Cognitive tests and assessment

    The expression levels of three synaptic proteins (synaptophysin, synaptotagmin, and growth-associated protein 43 [GAP43]) in AD cases clinically classified by Clinical Dementia Rating (CDR) score were analyzed.

  21. Neurotoxicity of HIV-1 proteins gp120 and Tat in the rat striatum

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Brain research 2000-10-01 Biomarkers

    HIV-associated dementia complex is a serious disabling disease characterized by cognitive, behavioral and motor dysfunction.

  22. Excitotoxicity, synaptic repair, and functional recovery in the mammalian cochlea: a review of recent findings

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Annals of the New York Academy of Sciences 1999-11-01 Brain scans and imaging

    Besides its fast excitatory properties, glutamate is known to have neurotoxic properties when released in large amounts or when incompletely recycled.

  23. Exercise, antidepressant medications, and enhanced brain derived neurotrophic factor expression

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 1999-11-01 Prevention trials

    Physical activity and antidepressant treatment have each separately been of significant interest for the management of Alzheimer's disease (AD); particularly the behavioral problems associated with this dementing disorder.

  24. Activation of the L voltage-sensitive calcium channel by mitogen-activated protein (MAP) kinase following exposure of neuronal cells to beta-amyloid. MAP kinase mediates beta-amyloid-induced neurodegeneration

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The Journal of biological chemistry 1999-10-01 Drug development

    Neuronal degeneration in Alzheimer's disease (AD) has been variously attributed to increases in cytosolic calcium, reactive oxygen species, and phosphorylated forms of the microtubule-associated protein tau. beta-Amyloid (betaA), which accumulates extracellularly in AD brain, induces calcium influx in culture via the L voltage-sensitive calcium channel.

  25. Lithium at 50: have the neuroprotective effects of this unique cation been overlooked?

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Biological psychiatry 1999-10-01 Drug development

    Recent advances in cellular and molecular biology have resulted in the identification of two novel, hitherto completely unexpected targets of lithium's actions, discoveries that may have a major impact on the future use of this unique cation in biology and medicine.

  26. Age-related cognitive deficits, impaired long-term potentiation and reduction in synaptic marker density in mice lacking the beta-amyloid precursor protein

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Neuroscience 1999-04-01 Biomarkers

    Mutations in the beta-amyloid precursor protein are strongly associated with some cases of familial Alzheimer's disease.

  27. Environmental enrichment inhibits spontaneous apoptosis, prevents seizures and is neuroprotective

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Nature medicine 1999-04-01 Risk factors

    The mammalian brain has a high degree of plasticity, with dentate granule cell neurogenesis and glial proliferation stimulated by an enriched environment combining both complex inanimate and social stimulation.

  28. Complete sequence of a novel protein containing a femtomolar-activity-dependent neuroprotective peptide

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of neurochemistry 1999-03-01 Disease mechanisms

    The vulnerability of neurons and the irreversibility of loss make discoveries of neuroprotective compounds fundamentally important.

  29. Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Nature neuroscience 1999-03-01 Risk genes beyond APOE

    We investigated synaptic communication and plasticity in hippocampal slices from mice overexpressing mutated 695-amino-acid human amyloid precursor protein (APP695SWE), which show behavioral and histopathological abnormalities simulating Alzheimer's disease.

  30. NF-kappa B: a crucial transcription factor for glial and neuronal cell function

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Trends in neurosciences 1997-06-01 Disease mechanisms

    Transcription factors provide the link between early membrane-proximal signalling events and changes in gene expression.

  31. Deficient glutamate tranport is associated with neurodegeneration in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Annals of Neurology 1996-11-01 Disease mechanisms

    The mechanisms of synapse damage in Alzheimer's disease (AD) are not fully understood.

  32. Hippocampal synaptic transmission enhanced by low concentrations of nicotine

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Nature 1996-10-01 Prevention and risk

    Nicotine obtained from tobacco can improve learning and memory on various tasks and has been linked to arousal, attention, rapid information processing, working memory, and long-term memories that can cause craving years after someone has stopped smoking.

  33. A femtomolar-acting neuroprotective peptide

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The Journal of clinical investigation 1996-05-01 Disease mechanisms

    A novel 14-amino acid peptide, with stress-protein-like sequences, exhibiting neuroprotection at unprecedented concentrations, is revealed.

  34. beta-Amyloid precursor protein metabolites and loss of neuronal Ca2+ homeostasis in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Trends in neurosciences 1993-10-01 Down syndrome and Alzheimer's

    Recent findings link altered processing of beta-amyloid precursor protein (beta APP) to disruption of neuronal Ca2+ homeostasis and an excitotoxic mechanism of cell death in Alzheimer's disease.

  35. GFAP mRNA increases with age in rat and human brain

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neurobiology of aging 1993-09-01 Biomarkers

    Glial fibrillary acidic protein (GFAP) mRNA was examined by RNA blot hybridization in three age groups of two cohorts of male F-344 rats and in 47 human postmortem brain samples.

  36. Heightened synaptic plasticity of hippocampal CA1 neurons during a cholinergically induced rhythmic state

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Nature 1993-08-01 Disease mechanisms

    Brain cholinergic neurons are critical for memory function and their loss may contribute to memory impairment in Alzheimer's disease.

  37. Neuronal cell killing by the envelope protein of HIV and its prevention by vasoactive intestinal peptide

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Nature 1988-10-01 Disease mechanisms

    The clinical manifestations of AIDS (acquired immune deficiency syndrome) often include neuropsychiatric and neurological deficits, including early memory loss and progressive dementia.

  38. Cholinergic innervation of cortex by the basal forebrain: Cytochemistry and cortical connections of the septal area, diagonal band nuclei, nucleus basalis (Substantia innominata), and hypothalamus in the rhesus monkey

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The Journal of Comparative Neurology 1983-02-20 Risk factors

    In Alzheimer's disease, the relatively selective depression of neocortical cholinergic innervation may be closely associated with the neuronal loss in Ch4, which has also been described inthis condition.

From across this tag

10 of the 288 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.

All topic tags with their study counts