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Home › Research › Topics › soluble

soluble

364 studies tagged soluble, dated 2000-05-01 to 2026-06-02. Bibliography: BibTeX (.bib) · RIS (.ris)

Newest in this topic

  1. Gain-of-function Modulation of TREM2 and its Impact on Amyloid-β and Tau Pathologies in Alzheimer's Disease: A Systematic Review and Meta-analysis of Animal Studies 2026-06-02
  2. The TREM2 agonistic antibody AL002 in early Alzheimer's disease: a phase 2 randomized trial 2026-03-05
  3. Decoding TREM2 Signaling Pathways 2026-01-09

Studies

364 studies carry this tag.

Date range

2000 to 2026

Top journals

  • Molecular neurodegeneration 26
  • Neurobiology of aging 16
  • Neuron 10
  • The Journal of experimental medicine 10
  • Acta neuropathologica 9

147 journals in all.

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

  1. The innate immune response to Salmonella enterica serovar Typhimurium by macrophages is dependent on TREM2-DAP12

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Infection and immunity 2008-04-07 TREM2 and immune genetics

    Macrophage recognition of Salmonella enterica serovar Typhimurium leads to a cascade of signaling events, including the activation of Src family and Syk kinases and the production of reactive oxygen species (ROS), which are critical for host innate defense during early stages of bacterial infection.

  2. TREM2-transduced myeloid precursors mediate nervous tissue debris clearance and facilitate recovery in an animal model of multiple sclerosis

    ✓ Peer-reviewed alzhub usefulness score 52 out of 100. PLoS medicine 2007-04-01 TREM2 and immune genetics

    In multiple sclerosis, inflammation can successfully be prevented, while promoting repair is still a major challenge.

  3. Essential role of the microglial triggering receptor expressed on myeloid cells-2 (TREM2) for central nervous tissue immune homeostasis

    ✓ Peer-reviewed alzhub usefulness score 44 out of 100. Journal of neuroimmunology 2007-01-18 TREM2 and immune genetics

    While there is a strong evidence for neural tissue destruction mediated by adaptive autoimmune responses, it is still debated how innate immune responses contribute to neuroinflammatory and neurodegenerative diseases such as multiple sclerosis and Alzheimer's disease.

  4. Cutting Edge: TREM-2 Attenuates Macrophage Activation

    ✓ Peer-reviewed alzhub usefulness score 53 out of 100. The Journal of Immunology 2006-09-01 TREM2 and immune genetics

    The triggering receptor expressed on myeloid cells 2 (TREM-2) delivers intracellular signals through the adaptor DAP12 to regulate myeloid cell function both within and outside the immune system.

  5. Cutting Edge: Inhibition of TLR and FcR Responses in Macrophages by Triggering Receptor Expressed on Myeloid Cells (TREM)-2 and DAP12

    ✓ Peer-reviewed alzhub usefulness score 53 out of 100. The Journal of Immunology 2006-08-01 TREM2 and immune genetics

    DAP12 is an ITAM-containing adapter that associates with receptors in myeloid and NK cells.

  6. TREM2, a DAP12-associated receptor, regulates osteoclast differentiation and function

    ✓ Peer-reviewed alzhub usefulness score 44 out of 100. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2005-10-20 TREM2 and immune genetics

    These results provide new evidence that TREM2 regulates OC function independent of its effects on multinucleated OC differentiation.

  7. Dap12 and Trem2, molecules involved in innate immunity and neurodegeneration, are co-expressed in the CNS

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Neurobiology of disease 2005-03-01 TREM2 and immune genetics

    Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL) is a recessively inherited disease characterized by early onset dementia associated with bone cysts.

  8. Distribution and signaling of TREM2/DAP12, the receptor system mutated in human polycystic lipomembraneous osteodysplasia with sclerosing leukoencephalopathy dementia

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. The European journal of neuroscience 2004-11-01 TREM2 and immune genetics

    Together with its adaptor protein, the adaptor protein of 12 kDa also known as KARAP and TYROBP (DAP12), triggering receptor expressed in myeloid cells 2 (TREM2) is a stimulatory membrane receptor of the immunoglobulin/lectin-like superfamily, well known in myeloid cells.

  9. DAP12/TREM2 deficiency results in impaired osteoclast differentiation and osteoporotic features

    ✓ Peer-reviewed alzhub usefulness score 52 out of 100. The Journal of experimental medicine 2003-08-01 TREM2 and immune genetics

    Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), Nasu-Hakola disease, is a globally distributed recessively inherited disease.

  10. Pattern Recognition by TREM-2: Binding of Anionic Ligands

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. The Journal of Immunology 2003-07-01 TREM2 and immune genetics

    We recently described the cloning of murine triggering receptor expressed by myeloid cells (TREM) 2, a single Ig domain DNAX adaptor protein 12-associated receptor expressed by cells of the myeloid lineage.

  11. TREMs in the immune system and beyond

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. Nature reviews. Immunology 2003-06-01 TREM2 and immune genetics

    Triggering receptors expressed by myeloid cells (TREMs) belong to a rapidly expanding family of receptors that include activating and inhibitory isoforms encoded by a gene cluster linked to the MHC.

  12. The human TREM gene cluster at 6p21.1 encodes both activating and inhibitory single IgV domain receptors and includes NKp44

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. European journal of immunology 2003-02-01 TREM2 and immune genetics

    We have characterized a cluster of single immunoglobulin variable (IgV) domain receptors centromeric of the major histocompatibility complex (MHC) on human chromosome 6.

  13. Heterogeneous expression of the triggering receptor expressed on myeloid cells‐2 on adult murine microglia

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Journal of Neurochemistry 2002-12-01 TREM2 and immune genetics

    Microglial activation is an early and common feature of almost all neuropathologies, including multiple sclerosis, Alzheimer's disease and mechanical injury.

  14. Cutting Edge: Inflammatory Responses Can Be Triggered by TREM-1, a Novel Receptor Expressed on Neutrophils and Monocytes

    ✓ Peer-reviewed alzhub usefulness score 49 out of 100. The Journal of Immunology 2000-05-01 Inflammation and the immune system

    We have identified new activating receptors of the Ig superfamily expressed on human myeloid cells, called TREM (triggering receptor expressed on myeloid cells).

From across this tag

10 of the 364 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.

All topic tags with their study counts