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Home › Research › Topics › presenilin

presenilin

344 studies tagged presenilin, dated 1985-12-01 to 2026-10-26. Bibliography: BibTeX (.bib) · RIS (.ris)

Newest in this topic

  1. Precision Nanocrystal Theranostics for Neurodegenerative Proteopathies: Strategies to Cross the Blood-Brain Barrier and Target Protein Aggregation 2026-10-26
  2. Temporal Proteomics Links the APP London Mutation to Early Cholesterol Remodeling Cell Programs in Human Neurons 2026-10-24
  3. Stimulating microglial neuroinflammation with amyloid-beta oligomers compatible with solid-state NMR structural characterization 2026-10-20

Studies

344 studies carry this tag.

Date range

1985 to 2026

Top journals

  • Proceedings of the National Academy of Sciences of the United States of America 35
  • Nature 23
  • The Journal of biological chemistry 15
  • Neuron 14
  • Science (New York, N.Y.) 12

147 journals in all.

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

  1. Molecular structure of amyloid fibrils: insights from solid-state NMR

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Quarterly Reviews of Biophysics 2006-02-01 Brain tissue and pathology

    References 46 Solid-state nuclear magnetic resonance (NMR) measurements have made major contributions to our understanding of the molecular structures of amyloid fibrils, including fibrils formed by the β-amyloid peptide associated with Alzheimer's disease, by proteins associated with fungal prions, and by a variety of other polypeptides.

  2. Experimental constraints on quaternary structure in Alzheimer's beta-amyloid fibrils

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Biochemistry 2006-01-01 Clinical safety

    We describe solid-state nuclear magnetic resonance (NMR) measurements on fibrils formed by the 40-residue beta-amyloid peptide associated with Alzheimer's disease (Abeta(1-40)) that place constraints on the identity and symmetry of contacts between in-register, parallel beta-sheets in the fibrils.

  3. BACE1, a major determinant of selective vulnerability of the brain to amyloid-beta amyloidogenesis, is essential for cognitive, emotional, and synaptic functions

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The Journal of neuroscience : the official journal of the Society for Neuroscience 2005-12-01 Disease mechanisms

    A transmembrane aspartyl protease termed beta-site APP cleavage enzyme 1 (BACE1) that cleaves the amyloid-beta precursor protein (APP), which is abundant in neurons, is required for the generation of amyloid-beta (Abeta) peptides implicated in the pathogenesis of Alzheimer's disease (AD).

  4. Increase of disintergin metalloprotease 10 (ADAM10) expression in oral squamous cell carcinoma

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Cancer letters 2005-11-23 Drug development

    The A disintergin and metalloprotease (ADAM) superfamilies play important roles in angiogenesis, development, and tumorigenesis.

  5. Binding of the positron emission tomography tracer Pittsburgh compound-B reflects the amount of amyloid-beta in Alzheimer's disease brain but not in transgenic mouse brain

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The Journal of neuroscience : the official journal of the Society for Neuroscience 2005-11-01 Brain scans and imaging

    During the development of in vivo amyloid imaging agents, an effort was made to use micro-positron emission tomography (PET) imaging in the presenilin-1 (PS1)/amyloid precursor protein (APP) transgenic mouse model of CNS amyloid deposition to screen new compounds and further study Pittsburgh Compound-B (PIB), a PET tracer that has been shown to be retained well in amyloid-containing areas of Alzheimer's disease (AD) brain.

  6. Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Proceedings of the National Academy of Sciences of the United States of America 2005-09-07 Risk genes beyond APOE

    sorLA (Sorting protein-related receptor) is a type-1 membrane protein of unknown function that is expressed in neurons.

  7. Globular amyloid beta-peptide oligomer - a homogenous and stable neuropathological protein in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of neurochemistry 2005-08-31 Disease mechanisms

    Amyloid beta-peptide (Abeta)(1-42) oligomers have recently been discussed as intermediate toxic species in Alzheimer's disease (AD) pathology.

  8. Amyloid ion channels: a common structural link for protein-misfolding disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Proceedings of the National Academy of Sciences of the United States of America 2005-07-14 Brain tissue and pathology

    Protein conformational diseases, including Alzheimer's, Huntington's, and Parkinson's diseases, result from protein misfolding, giving a distinct fibrillar feature termed amyloid.

  9. Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Nature 2005-06-01 Disease mechanisms

    The self-renewing epithelium of the small intestine is ordered into stem/progenitor crypt compartments and differentiated villus compartments.

  10. Structural properties of Abeta protofibrils stabilized by a small molecule

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Proceedings of the National Academy of Sciences of the United States of America 2005-05-09 Treatments

    Metastable oligomeric and protofibrillar forms of amyloidogenic proteins have been implicated as on-pathway assembly intermediates in amyloid formation and as the major toxic species in a number of amyloid diseases including Alzheimer's disease.

  11. Age- and region-dependent alterations in Abeta-degrading enzymes: implications for Abeta-induced disorders

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neurobiology of aging 2005-05-01 Down syndrome and Alzheimer's

    Accumulation of amyloid beta-protein (Abeta) is a fundamental feature of certain human brain disorders such as Alzheimer's disease (AD) and Down syndrome and also of the skeletal muscle disorder inclusion body myositis (IBM).

  12. Abnormal accumulation of citrullinated proteins catalyzed by peptidylarginine deiminase in hippocampal extracts from patients with Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of neuroscience research 2005-04-01 Biomarkers

    Citrullinated proteins are the products of a posttranslational process in which arginine residues undergo modification into citrulline residues when catalyzed by peptidylarginine deiminases (PADs) in a calcium ion-dependent manner.

  13. Axonopathy and transport deficits early in the pathogenesis of Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Science (New York, N.Y.) 2005-02-01 Risk genes beyond APOE

    We identified axonal defects in mouse models of Alzheimer's disease that preceded known disease-related pathology by more than a year; we observed similar axonal defects in the early stages of Alzheimer's disease in humans.

  14. Presenilin 2 familial Alzheimer's disease mutations result in partial loss of function and dramatic changes in Abeta 42/40 ratios

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of neurochemistry 2005-01-01 Biomarkers

    Gene knockout studies in mice suggest that presenilin 1 (PS1) is the major gamma-secretase and that it contributes disproportionately to amyloid beta (Abeta) peptide generation from beta-amyloid precursor protein (APP), whereas PS2 plays a more minor role.

  15. The binding of thioflavin-T to amyloid fibrils: localisation and implications

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of structural biology 2005-01-01 Prevention and risk

    Amyloid fibrils are a polymeric form of protein, involving a continuous beta-sheet with the strands perpendicular to the long axis of the fibril.

  16. A modified beta-amyloid hypothesis: intraneuronal accumulation of the beta-amyloid peptide--the first step of a fatal cascade

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of neurochemistry 2004-11-01 Down syndrome and Alzheimer's

    Accumulating evidence points to an important role of intraneuronal A beta as a trigger of the pathological cascade of events leading to neurodegeneration and eventually to Alzheimer's disease (AD) with its typical clinical symptoms, like memory impairment and change in personality.

  17. Abeta localization in abnormal endosomes: association with earliest Abeta elevations in AD and Down syndrome

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Neurobiology of aging 2004-11-01 Down syndrome and Alzheimer's

    Early endosomes are a major site of amyloid precursor protein (APP) processing and a convergence point for molecules of pathologic relevance to Alzheimer's disease (AD).

  18. Synaptic changes in Alzheimer's disease: increased amyloid-beta and gliosis in surviving terminals is accompanied by decreased PSD-95 fluorescence

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. The American journal of pathology 2004-11-01 Biomarkers

    In an effort to examine changes that precede synapse loss, we have measured amyloid-beta and a series of damage markers in the synaptic compartment of Alzheimer's disease (AD) cases.

  19. Synaptic targeting by Alzheimer's-related amyloid beta oligomers

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The Journal of neuroscience : the official journal of the Society for Neuroscience 2004-11-01 Disease mechanisms

    The cognitive hallmark of early Alzheimer's disease (AD) is an extraordinary inability to form new memories.

  20. The Caenorhabditis elegans IMPAS gene, imp-2, is essential for development and is functionally distinct from related presenilins

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Proceedings of the National Academy of Sciences 2004-10-06 Drug development

    Presenilins (PSs) are required for Notch signaling in the development of vertebrates and invertebrates.

  21. Reduced beta-amyloid production and increased inflammatory responses in presenilin conditional knock-out mice

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The Journal of biological chemistry 2004-09-01 Biomarkers

    Mutations in presenilins (PS) 1 and 2 are the major cause of familial Alzheimer's disease.

  22. Strategies for disease modification in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Nature reviews. Neuroscience 2004-09-01 Treatments

    Treating Alzheimer's disease (AD) is the biggest unmet medical need in neurology.

  23. Techniques to study amyloid fibril formation in vitro

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Methods (San Diego, Calif.) 2004-09-01 Risk factors

    Amyloid fibrils are ordered aggregates of peptides or proteins that are fibrillar in structure and contribute to the complications of many diseases (e.g., type 2 diabetes mellitus, Alzheimer's disease, and primary systemic amyloidosis).

  24. LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neuron 2004-08-01 Vascular contributions

    LRP (low-density lipoprotein receptor-related protein) is linked to Alzheimer's disease (AD).

  25. Proteomic characterization of postmortem amyloid plaques isolated by laser capture microdissection

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. The Journal of biological chemistry 2004-06-25 Genetics

    The presence of amyloid plaques in the brain is one of the pathological hallmarks of Alzheimer's disease (AD).

  26. The role of ADAM10 and ADAM17 in the ectodomain shedding of angiotensin converting enzyme and the amyloid precursor protein

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. European journal of biochemistry 2004-06-01 Drug development

    Numerous transmembrane proteins, including the blood pressure regulating angiotensin converting enzyme (ACE) and the Alzheimer's disease amyloid precursor protein (APP), are proteolytically shed from the plasma membrane by metalloproteases.

  27. Oligomerization of Alzheimer's β-Amyloid within Processes and Synapses of Cultured Neurons and Brain

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Journal of Neuroscience 2004-04-07 Disease mechanisms

    Multiple lines of evidence implicate beta-amyloid (Abeta) in the pathogenesis of Alzheimer's disease (AD), but the mechanisms whereby Abeta is involved remain unclear.

  28. Imaging beta-amyloid plaques and neurofibrillary tangles in the aging human brain

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Current pharmaceutical design 2004-01-01 Treatments

    The development of radioligands to image beta-amyloid (A beta) plaques and neurofibrillary tangles (NFTs) in vivo in the aging human brain is an important and active area of radiopharmaceutical design.

  29. Prediction of proprotein convertase cleavage sites

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Protein engineering, design & selection : PEDS 2004-01-01 Digital health tools

    Many secretory proteins and peptides are synthesized as inactive precursors that in addition to signal peptide cleavage undergo post-translational processing to become biologically active polypeptides.

  30. Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neurobiology of aging 2003-12-01 Risk genes beyond APOE

    Amyloid-beta (Abeta) containing plaques and tau-laden neurofibrillary tangles are the defining neuropathological features of Alzheimer's disease (AD).

  31. Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Human molecular genetics 2003-11-25 Biomarkers

    Amyloid precursor protein (APP) is endoproteolytically processed by BACE1 and gamma-secretase to release amyloid peptides (Abeta40 and 42) that aggregate to form senile plaques in the brains of patients with Alzheimer's disease (AD).

  32. Alzheimer's disease-affected brain: presence of oligomeric A beta ligands (ADDLs) suggests a molecular basis for reversible memory loss

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Proceedings of the National Academy of Sciences of the United States of America 2003-08-18 Disease mechanisms

    A molecular basis for memory failure in Alzheimer's disease (AD) has been recently hypothesized, in which a significant role is attributed to small, soluble oligomers of amyloid beta-peptide (A beta).

  33. Spherical aggregates of beta-amyloid (amylospheroid) show high neurotoxicity and activate tau protein kinase I/glycogen synthase kinase-3beta

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Proceedings of the National Academy of Sciences of the United States of America 2003-05-15 Drug development

    beta-Amyloid (Abeta) acquires toxicity by self-aggregation.

  34. Gamma-secretase is a membrane protein complex comprised of presenilin, nicastrin, Aph-1, and Pen-2

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Proceedings of the National Academy of Sciences of the United States of America 2003-05-09 Risk genes beyond APOE

    gamma-Secretase catalyzes the intramembrane proteolysis of Notch, beta-amyloid precursor protein, and other substrates as part of a new signaling paradigm and as a key step in the pathogenesis of Alzheimer's disease.

  35. GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Nature 2003-05-01 Risk genes beyond APOE

    Alzheimer's disease is associated with increased production and aggregation of amyloid-beta (Abeta) peptides.

  36. Reconstitution of gamma-secretase activity

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Nature cell biology 2003-05-01 Risk genes beyond APOE

    gamma-Secretase is a membrane protein complex with an unusual aspartyl protease activity that catalyses the regulated intramembranous cleavage of the beta-amyloid precursor protein (APP) to release the Alzheimer's disease (AD)-associated amyloid beta-peptide (Abeta) and the APP intracellular domain (AICD).

  37. Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neuron 2003-04-01 Risk genes beyond APOE

    Gamma-Secretase cleaves the Amyloid Precursor Protein (APP) in its transmembrane domain, releasing the amyloid peptide Abeta.

  38. The metallobiology of Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Trends in neurosciences 2003-04-01 How common it is

    The cause of Alzheimer's disease (AD) is closely related to the aggregation of a normal protein, beta-amyloid (Abeta), within the neocortex.

  39. The role of presenilin cofactors in the gamma-secretase complex

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Nature 2003-03-16 Risk genes beyond APOE

    Mutations in presenilin genes account for the majority of the cases of the familial form of Alzheimer's disease (FAD).

  40. beta-Amyloid aggregation induced by human acetylcholinesterase: inhibition studies

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Biochemical pharmacology 2003-02-01 Treatments

    The aggregation of beta-amyloid (1-40) (Abeta) induced by human recombinant acetylcholinesterase (HuAChE) was studied by means of circular dichroism (CD) and by thioflavin T fluorescence spectroscopy.

  41. Efflux of human and mouse amyloid beta proteins 1-40 and 1-42 from brain: impairment in a mouse model of Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neuroscience 2003-01-01 Drug development

    Brain to blood transport is believed to be a major determinant of the amount of amyloid beta protein (AbetaP) found in brain.

  42. Lipid rafts: structure, function and role in HIV, Alzheimer's and prion diseases

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Expert Reviews in Molecular Medicine 2002-12-20 Drug development

    The fluid mosaic model of the plasma membrane has evolved considerably since its original formulation 30 years ago.

  43. Amyloid-beta induces Smac release via AP-1/Bim activation in cerebral endothelial cells

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The Journal of neuroscience : the official journal of the Society for Neuroscience 2002-11-01 Drug development

    Insoluble fibrils of amyloid-beta peptide (Abeta) are the major component of senile and vascular plaques found in the brains of Alzheimer's disease (AD) patients.

  44. Molecular targeting of Alzheimer's amyloid plaques for contrast-enhanced magnetic resonance imaging

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neurobiology of disease 2002-11-01 Treatments

    Smart molecular probes for both diagnostic and therapeutic purposes are expected to provide significant advances in clinical medicine and biomedical research.

  45. The Alzheimer's A beta -peptide is deposited at sites of complement activation in pathologic deposits associated with aging and age-related macular degeneration

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Proceedings of the National Academy of Sciences of the United States of America 2002-08-20 Brain scans and imaging

    Age-related macular degeneration (AMD) is a leading cause of irreversible vision loss in older individuals worldwide.

  46. Neurodegenerative disease: amyloid pores from pathogenic mutations

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Nature 2002-07-01 Brain tissue and pathology

    Alzheimer's and Parkinson's diseases are associated with the formation in the brain of amyloid fibrils from beta-amyloid and alpha-synuclein proteins, respectively.

  47. Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Nature neuroscience 2002-05-01 Tau biomarkers

    We have previously shown that chronic treatment with the monoclonal antibody m266, which is specific for amyloid beta-peptide (Abeta), increases plasma concentrations of Abeta and reduces Abeta burden in the PDAPP transgenic mouse model of Alzheimer's disease (AD).

  48. A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The EMBO journal 2002-04-01 Risk genes beyond APOE

    E-cadherin controls a wide array of cellular behaviors including cell-cell adhesion, differentiation and tissue development.

  49. Increased expression of intranuclear AChE involved in apoptosis of SK-N-SH cells

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neuroscience research 2002-04-01 Drug development

    Programmed cell death plays an integral role in neurodegenerative diseases such as Alzheimer's disease (AD).

  50. A novel presenilin 2 gene mutation (D439A) in a patient with early-onset Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. Neurology 2001-11-27 Risk genes beyond APOE

    The authors describe a novel missense mutation in the presenilin 2 (PSEN2) gene at residue 439 that predicts an aspartate-to-alanine substitution (D439A).

From across this tag

7 of the 344 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 7. The same 7 appear here every time.

All topic tags with their study counts