Home › Research › Topics › melatonin
melatonin
196 studies tagged melatonin, dated 1983 to 2026-10-16. Bibliography: BibTeX (.bib) · RIS (.ris)
Newest in this topic
- Progressive neurodegeneration of the locus coeruleus drives rapid eye movement sleep fragmentation 2026-10-16
- REM sleep EEG slowing signals basal forebrain integrity in older adults with subjective and mild cognitive impairment 2026-10-02
- A systems-level model of sleep-dependent memory-consolidation failure in neurodegeneration: the spindle–slow-oscillation decoupling cascade dissociates amyloid and tau 2026-09-29
Studies
196 studies carry this tag.
Date range
1983 to 2026
Top journals
- Alzheimer's & dementia : the journal of the Alzheimer's Association 12
- bioRxiv 7
- medRxiv 7
- Journal of Alzheimer's disease : JAD 6
- Sleep 5
128 journals in all.
Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.
-
Lumbar puncture (LP) is a common way of collecting cerebrospinal fluid (CSF) both in the clinic and in research.
-
Increasing evidence links cognitive-decline and Alzheimer's disease (AD) to various sleep disorders, including obstructive sleep apnea (OSA).
-
Decreased sleep time in the elderly is a precipitating factor in amyloid retention.
-
41/100
Five out of six enrolled dyads completed the sessions.
-
39/100
Insomnia is associated with socioeconomic status, racial and ethnic classification, family relationships, medical and mental health disorders, cognitive function, and dementia.
-
As we age, we experience changes in our nighttime sleep and daytime wakefulness.
-
Insomnia is a common sleep disorder among older adults, and a risk factor for poor physical and mental health.
-
The prevalence of mild cognitive impairment (MCI) increases among elderly people and is associated with a high risk of dementia.
-
Dysfunction in 24-h circadian rhythms is a common occurrence in ageing adults; however, circadian rhythm disruptions are more severe in people with age-related neurodegenerative diseases, including Alzheimer's disease and related dementias, and Parkinson's disease.
-
The sleep-wake cycle regulates interstitial fluid (ISF) and cerebrospinal fluid (CSF) levels of β-amyloid (Aβ) that accumulates in Alzheimer's disease (AD).
-
53/100
In Alzheimer's disease (AD), deposition of insoluble amyloid-β (Aβ) is followed by intracellular aggregation of tau in the neocortex and subsequent neuronal cell loss, synaptic loss, brain atrophy, and cognitive impairment.
-
Obstructive sleep apnea (OSA) is a prevalent sleep related breathing disorder characterized by repetitive collapse of the upper airways leading to intermittent hypoxia and sleep disruption.
-
Sleep and wakefulness disorders are commonly seen in patients with Parkinson's disease, Lewy body dementia and Alzheimer's disease.
-
Sleep problems occur commonly in normal and pathologic aging.
-
Furthermore, PET studies have revealed that Aβ accumulates in the healthy brain after a single night of sleep deprivation, suggesting that the human glymphatic pathway might also be primarily active during sleep.
-
Mutations in fused in sarcoma (Fus) cause familial amyotrophic lateral sclerosis (ALS) and occasionally frontotemporal dementia.
-
Midlife insomnia (fully adjusted hazard ratio = 1.24, 95% confidence interval = 1.02-1.50) and late-life terminal insomnia (fully adjusted odds ratio = 1.94, 95% confidence interval = 1.08-3.49) were associated with a higher dementia risk.
-
Cerebrospinal fluid (CSF) is a fluidic part of the brain's microenvironment that isolates the brain from the rest of the body.
-
Baseline EDS was associated with increased longitudinal Aβ accumulation in elderly persons without dementia, suggesting that those with EDS may be more vulnerable to pathologic changes associated with Alzheimer disease.
-
Insomnia is a common problem in older people, especially in patients with mild cognitive impairment (MCI) whose circadian rhythm is often compromised.
-
The effects of acute sleep deprivation on β-amyloid (Aβ) clearance in the human brain have not been documented.
-
41/100
In mammals, a central circadian clock, located in the suprachiasmatic nuclei (SCN) of the hypothalamus, tunes the innate circadian physiological rhythms to the ambient 24 h light-dark cycle to invigorate and optimize the internal temporal order.
-
Sleep disturbances are associated with future risk of Alzheimer disease.
-
The article reviews the phenomenology of sleep and wakefulness disorders in Parkinson's disease and Alzheimer's disease.
-
Increased age is associated with normative declines in both sleep and cognitive functioning.
-
Alzheimer's disease (AD) is a significant public health concern.
-
The endogenous circadian rhythms are one of the cardinal processes that control sleep.
-
Approximately half of older people report sleep disturbances, which are associated with various health conditions, including neurodegenerative disease and dementia.
-
See Mander et al. (doi:10.1093/awx174) for a scientific commentary on this article.
-
Alzheimer's disease (AD), which accounts for most of the dementia cases, is, aside from cognitive deterioration, often characterized by the presence of non-cognitive symptoms.
-
The nerve center responsible for controlling our circadian rhythm is located in a cluster of cells known as the suprachiasmatic nucleus in the hypothalamus.
-
Sleep disturbances such as insomnia, hypersomnia, and circadian rhythm disturbance are common in normal elderly and Alzheimer's disease (AD) patients.
-
Alzheimer's disease (AD) is increasing in prevalence and has a significant impact on caregivers and the healthcare system.
-
Although some sleep disorders are markers of prodromal Parkinson's disease and dementia with Lewy bodies, it is unclear whether insomnia and somnolence can predict disease.
-
Alzheimer's disease (AD) is the most common cause of dementia and currently there are no effective disease-modifying treatments available.
-
Study objectives Mounting evidence implicates disturbed sleep or lack of sleep as one of the risk factors for Alzheimer's disease (AD), but the extent of the risk is uncertain.
-
Sleep deprivation can lead to an elevation of plasma Aβ40 and decrease of the Aβ42/Aβ40 ratio.
-
Disruptions of normal circadian rhythms and sleep cycles are consequences of aging and can profoundly affect health.
-
Sleep disorders appear to be frequent comorbidities in patients with frontotemporal dementia (FTD).
-
Sleep disruption appears to be a core component of Alzheimer's disease (AD) and its pathophysiology.
-
41/100
We hypothesized that one mechanism underlying the association between obstructive sleep apnea (OSA) and Alzheimer's disease is OSA leading to decreased slow wave activity (SWA), increased synaptic activity, decreased glymphatic clearance, and increased amyloid-β.
-
Sleep-wake cycles are known to be disrupted in people with neurodegenerative disorders.
-
The older patient population is growing rapidly around the world and in the USA.
-
Sleep apnoea was associated with more common other respiratory concerns, and more frequent visits to physicians, but not with some expected medical comorbidities (cardiac).
-
A critical link between amyloid-beta (Aβ) and hypoxia has been demonstrated in in vitro and animal studies but has not yet been proven in humans.
-
The suprachiasmatic nucleus (SCN) of the hypothalamus, the master mammalian circadian pacemaker, synchronizes endogenous rhythms with the external day-night cycle.
-
Midlife may be an ideal window for intervention in Alzheimer's disease (AD).
-
Nocturnal hypoxemia was related to greater decline on the 3 MS .
-
The findings may help clinicians identify athletes who are at risk for worse impairments after a concussion due to preinjury sleep difficulties.
-
Down syndrome is a common disorder associated with intellectual disability in humans.
From across this tag
7 of the 196 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 7. The same 7 appear here every time.
- Clinical uses of melatonin: evaluation of human trials
- Plasma neurofilament light chain as a predictor of multiple system atrophy in idiopathic REM sleep behavior disorder
- Trajectories of sleep duration and timing before dementia: a 14-year follow-up study
- Short sleep duration and dementia: a narrative review
- Environmental risk factors for REM sleep behavior disorder: a multicenter case-control study
- Plasma NfL, GFAP, and pTau181 in patients with isolated REM sleep behavior disorder
- Alterations in the circadian rest-activity rhythm in aging and Alzheimer's disease