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Home › Research › Topics › insomnia

insomnia

196 studies tagged insomnia, dated 1983 to 2026-10-16. Bibliography: BibTeX (.bib) · RIS (.ris)

Newest in this topic

  1. Progressive neurodegeneration of the locus coeruleus drives rapid eye movement sleep fragmentation 2026-10-16
  2. REM sleep EEG slowing signals basal forebrain integrity in older adults with subjective and mild cognitive impairment 2026-10-02
  3. A systems-level model of sleep-dependent memory-consolidation failure in neurodegeneration: the spindle–slow-oscillation decoupling cascade dissociates amyloid and tau 2026-09-29

Studies

196 studies carry this tag.

Date range

1983 to 2026

Top journals

  • Alzheimer's & dementia : the journal of the Alzheimer's Association 12
  • bioRxiv 7
  • medRxiv 7
  • Journal of Alzheimer's disease : JAD 6
  • Sleep 5

128 journals in all.

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

  1. Melatonin for Sleep Disorders and Cognition in Dementia

    ✓ Peer-reviewed alzhub usefulness score 52 out of 100. American Journal of Alzheimer's Disease & Other Dementias® 2015-01-22 Risk factors

    The current review aims to examine melatonin therapy for both sleep disturbances and cognitive function in dementia.

  2. Effects of Chronic REM Sleep Restriction on D 1 Receptor and Related Signal Pathways in Rat Prefrontal Cortex

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. BioMed Research International 2015 Risk factors

    The prefrontal cortex (PFC) mediates cognitive function that is sensitive to disruption by sleep loss, and molecular mechanisms regulating neural dysfunction induced by chronic sleep restriction (CSR), particularly in the PFC, have yet to be completely understood.

  3. Sleep, Cognition, and Normal Aging

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Perspectives on Psychological Science 2015-01 Risk factors

    Sleep is implicated in cognitive functioning in young adults.

  4. Sleep-related behaviors in Alzheimer’s disease and dementia with Lewy bodies

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Reviews in the Neurosciences 2015-01-01 Risk factors

    Prevalence studies suggest that Alzheimer’s disease (AD) and dementia with Lewy bodies (DLB) are the most common dementing illnesses in the elderly.

  5. 'The clocks that time us'--circadian rhythms in neurodegenerative disorders

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Nature reviews. Neurology 2014-11-11 Risk factors

    Circadian rhythms are physiological and behavioural cycles generated by an endogenous biological clock, the suprachiasmatic nucleus.

  6. Sleep and Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Sleep medicine reviews 2014-04-03 Risk factors

    Sleep disorders are frequent in Alzheimer's disease (AD), with a significant impact on patients and caregivers and a major risk factor for early institutionalization.

  7. Sleep deprivation impairs memory, tau metabolism, and synaptic integrity of a mouse model of Alzheimer's disease with plaques and tangles

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neurobiology of aging 2014-02-15 Biomarkers

    Several studies have highlighted the frequency of sleep disturbances in Alzheimer's disease (AD).

  8. [Sleep problems in dementia]

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Rinsho shinkeigaku = Clinical neurology 2014 Risk factors

    Sleep disturbance is common in patients with dementia.

  9. Self-reported sleep and β-amyloid deposition in community-dwelling older adults

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. JAMA neurology 2013-12-01 Brain scans and imaging

    Among community-dwelling older adults, reports of shorter sleep duration and poorer sleep quality are associated with greater Aβ burden.

  10. Sleep apnea and the risk of dementia: a population-based 5-year follow-up study in Taiwan

    ✓ Peer-reviewed alzhub usefulness score 71 out of 100. PloS one 2013-10-24 Costs and economics

    SA may be a gender-dependent, age-dependent, and time-dependent risk factor for dementia.

  11. Functional neuroanatomy of the central noradrenergic system

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of psychopharmacology (Oxford, England) 2013-06-12 Risk factors

    The central noradrenergic neurone, like the peripheral sympathetic neurone, is characterized by a diffusely arborizing terminal axonal network.

  12. Disruption of the sleep-wake cycle and diurnal fluctuation of β-amyloid in mice with Alzheimer's disease pathology

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Science translational medicine 2012-09-01 Tau biomarkers

    Aggregation of β-amyloid (Aβ) in the brain begins to occur years before the clinical onset of Alzheimer's disease (AD).

  13. Environmental risk factors for REM sleep behavior disorder: a multicenter case-control study

    ✓ Peer-reviewed alzhub usefulness score 66 out of 100. Neurology 2012-06-27 Risk factors

    Smoking, head injury, pesticide exposure, and farming are potential risk factors for idiopathic REM sleep behavior disorder.

  14. Concurrent impairments in sleep and memory in amnestic mild cognitive impairment

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of the International Neuropsychological Society : JINS 2012-02-03 Risk factors

    Whereas patients with Alzheimer's disease (AD) experience difficulties forming and retrieving memories, their memory impairments may also partially reflect an unrecognized dysfunction in sleep-dependent consolidation that normally stabilizes declarative memory storage across cortical areas.

  15. Sleep epidemiology--a rapidly growing field

    ✓ Peer-reviewed alzhub usefulness score 71 out of 100. International Journal of Epidemiology 2011-12-01 Drug development

    First, sleep problems are associated with accidents and human errors.

  16. A survey of molecular details in the human pineal gland in the light of phylogeny, structure, function and chronobiological diseases

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of pineal research 2011-04-26 Risk factors

    The human pineal gland is a neuroendocrine transducer that forms an integral part of the brain.

  17. Characterization of the 3xTg-AD mouse model of Alzheimer's disease: part 1. Circadian changes

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Brain research 2010-05-31 Disease mechanisms

    Circadian disturbances, including a fragmented sleep-wake pattern and sundowning, are commonly reported early in the progression of Alzheimer's disease (AD).

  18. Clinical uses of melatonin: evaluation of human trials

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Current medicinal chemistry 2010-01-01 Brain scans and imaging

    During the last 20 years, numerous clinical trials have examined the therapeutic usefulness of melatonin in different fields of medicine.

  19. Bright light therapy

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Neuro endocrinology letters 2008-11 Risk factors

    Bright light is a treatment of choice for seasonal affective disorder.

  20. Physiological effects of melatonin: role of melatonin receptors and signal transduction pathways

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Progress in neurobiology 2008-04-16 Brain scans and imaging

    Melatonin, an endogenous signal of darkness, is an important component of the body's internal time-keeping system.

  21. Melatonin and bright-light treatment for rest-activity disruption in institutionalized patients with Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 70 out of 100. Journal of the American Geriatrics Society 2007-12-07 Digital health tools

    Light treatment alone did not improve nighttime sleep, daytime wake, or rest-activity rhythm.

  22. The role of circadian clock genes in mental disorders

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Dialogues in Clinical Neuroscience 2007-09-30 Drug development

    The study of molecular clock mechanisms in psychiatric disorders is gaining significant interest due to data suggesting that a misalignment between the endogenous circadian system and the sleep-wake cycle might contribute to the clinical status of patients suffering from a variety of psychiatric disorders.

  23. Sleep deprivation as a neurobiologic and physiologic stressor: Allostasis and allostatic load

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Metabolism: clinical and experimental 2006-10-01 Risk factors

    Sleep has important homeostatic functions, and sleep deprivation is a stressor that has consequences for the brain, as well as many body systems.

  24. Acetylcholinesterase inhibitors and sleep architecture in patients with Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. Drugs & aging 2006 Treatments

    AChEI therapy had a significant effect on the percentage of stage 1 (p = 0.01) and stage 2 (p = 0.03) sleep.

  25. Role of melatonin in Alzheimer-like neurodegeneration

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Acta pharmacologica Sinica 2006-01-01 Treatments

    Alzheimer disease (AD), an age-related neurodegenerative disorder with progressive loss of memory and deterioration of comprehensive cognition, is characterized by extracellular senile plaques of aggregated beta-amyloid (Abeta), and intracellular neurofibrillary tangles that contain hyperphosphorylated tau protein.

  26. The human pineal gland and melatonin in aging and Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of pineal research 2005-04-01 Brain scans and imaging

    The pineal gland is a central structure in the circadian system which produces melatonin under the control of the central clock, the suprachiasmatic nucleus (SCN).

  27. Sleep disturbance in mild to moderate Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Sleep medicine 2005-03-31 Risk factors

    Sleep disturbance in AD is associated with other behavioural symptoms, notably aggressiveness.

  28. Low acetylcholine during slow-wave sleep is critical for declarative memory consolidation

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Proceedings of the National Academy of Sciences of the United States of America 2004-02-06 Treatments

    The neurotransmitter acetylcholine is considered essential for proper functioning of the hippocampus-dependent declarative memory system, and it represents a major neuropharmacological target for the treatment of memory deficits, such as those in Alzheimer's disease.

  29. A multicenter, placebo-controlled trial of melatonin for sleep disturbance in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 56 out of 100. Sleep 2003-11-01 Risk factors

    Based on actigraphy as an objective measure of sleep time, melatonin is not an effective soporific agent in people with Alzheimer's disease.

  30. Melatonin for treatment of REM sleep behavior disorder in neurologic disorders: results in 14 patients

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Sleep medicine 2003-07-01 Brain scans and imaging

    Fourteen patients were commenced on melatonin over the specified time period (13 male, median RBD onset age 56 years, range 20-77 years).

  31. Melatonin rhythmicity: effect of age and Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Experimental gerontology 2003-01-01 Brain scans and imaging

    The circadian rhythm of the pineal gland hormone, melatonin is generated within the hypothalamic suprachiasmatic nuclei (SCN), site of the circadian clock.

  32. Double blind randomised placebo controlled trial of low dose melatonin for sleep disorders in dementia

    ✓ Peer-reviewed alzhub usefulness score 75 out of 100. International journal of geriatric psychiatry 2002-12 Clinical trials

    Twenty-five out of 44 completed the trial.

  33. Sundowning and circadian rhythms in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. The American journal of psychiatry 2001-05-01 Risk factors

    These data indicate that Alzheimer's disease causes disturbances of circadian rhythms and that sundowning is related to a phase delay of body temperature caused by Alzheimer's disease.

  34. Sleep disturbances in patients with Alzheimer's disease: epidemiology, pathophysiology and treatment

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. CNS drugs 2001-01-01 Health systems and care delivery

    Older adults represent an ever-growing proportion of the population of the industrialised nations, with a corresponding increase in the numbers of patients with dementing disorders.

  35. Melatonin and climactery

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Medical science monitor : international medical journal of experimental and clinical research 2000 Risk factors

    Melatonin is a hormone synthesized in the pineal gland from tryptophan.

  36. Bright light therapy: improved sensitivity to its effects on rest-activity rhythms in Alzheimer patients by application of nonparametric methods

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Chronobiology international 1999-07-01 Risk factors

    Sleep-wake rhythm disturbances in patients with Alzheimer's disease (AD) make a strong demand on caregivers and are among the most important reasons for institutionalization.

  37. Decreased Melatonin Levels in Postmortem Cerebrospinal Fluid in Relation to Aging, Alzheimer’s Disease, and Apolipoprotein E-ε4/4 Genotype1

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. The Journal of Clinical Endocrinology & Metabolism 1999-01-01 Risk factors

    Sleep disruption, nightly restlessness, sundowning, and other circadian disturbances are frequently seen in Alzheimer's disease (AD) patients.

  38. [Sleep disorders and dementia]

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Praxis 1997-08-27 Risk factors

    A clinically relevant sleep-wake disturbance is found in up to half the patients with dementia, and the sundowning agitation is a common cause of institutionalisation of demented geriatric patients.

  39. Indirect bright light improves circadian rest-activity rhythm disturbances in demented patients

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Biological psychiatry 1997-05-01 Risk factors

    Light is known to be an important modulator of circadian rhythms.

  40. Variations in circadian rhythms of activity, sleep, and light exposure related to dementia in nursing-home patients

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Sleep 1997-01-01 Health systems and care delivery

    We measured 24-hour circadian-rhythm patterns of activity and sleep/wake activity in a group of nursing-home patients (58 women and 19 men with a mean age of 85.7 years).

  41. Circadian rest-activity rhythm disturbances in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Biological psychiatry 1996-08-01 Risk factors

    Previous studies showed circadian rhythm disturbances in patients with Alzheimer's disease.

  42. Morning bright light therapy for sleep and behavior disorders in elderly patients with dementia

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Acta Psychiatrica Scandinavica 1994-01-01 Risk factors

    Fourteen inpatients with dementia showing sleep and behavior disorders (average age = 75 years), and 10 control elderly people (average age = 75 years) were carefully observed for 2 months.

  43. Does sleep disturbance predict depression in elderly people? A study in inner London

    ✓ Peer-reviewed alzhub usefulness score 64 out of 100. Europe PMC (PubMed Central) 1993-11-01 Risk factors

    Insomnia in elderly people has traditionally been regarded as inevitable and trivial.

  44. Alterations in the circadian rest-activity rhythm in aging and Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Biological psychiatry 1990-03-01 Risk factors

    The suprachiasmatic nucleus, considered to be the endogenous circadian clock in the mammalian brain, shows morphological changes with aging, which become even more pronounced in Alzheimer's disease (AD).

  45. Rapid eye movement sleep behavior disorder. A treatable parasomnia affecting older adults

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. JAMA 1987-04-01 Brain scans and imaging

    Rapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia defined by intermittent loss of electromyographic atonia during REM sleep with emergence of complex and vigorous behaviors.

  46. Sleep apnea: relationship to age, sex, and Alzheimer's dementia

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Sleep 1983 Risk factors

    The relationship of sleep apnea to age, sex, and Alzheimer's dementia was investigated in 45 elderly subjects and 10 young males, all nonobese, normotensive, nonsmoking, with no sleep complaints and no medical problems other than Alzheimer's disease.

From across this tag

8 of the 196 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 8. The same 8 appear here every time.

All topic tags with their study counts