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Home › Research › Topic

Disease mechanisms in lab and animal studies

1,352 studies in this group. A computer grouped them by what their titles and summaries are about, not by a hand-made list. The name describes most of the group, not every study in it.

Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.

Highest usefulness score first. Studies without a score come last.

  1. DSCR1, overexpressed in Down syndrome, is an inhibitor of calcineurin-mediated signaling pathways

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Human molecular genetics 2000-07-01 Down syndrome and Alzheimer's

    Down syndrome is one of the major causes of mental retardation and congenital heart malformations.

  2. Casein kinase 1 delta is associated with pathological accumulation of tau in several neurodegenerative diseases

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neurobiology of aging 2000-07-01 Down syndrome and Alzheimer's

    The distribution of casein kinase 1 delta (Cki delta) was studied by immunohistochemistry and correlated with other pathological hallmarks in Alzheimer's disease (AD), Down syndrome (DS), progressive supranuclear palsy (PSP), parkinsonism dementia complex of Guam (PDC), Pick's disease (PiD), pallido-ponto-nigral degeneration (PPND), Parkinson's disease (PD), dementia with Lewy bodies (DLB), amyotrophic lateral sclerosis (ALS), and elderly controls.

  3. On neurodegenerative diseases, models, and treatment strategies: lessons learned and lessons forgotten a generation following the cholinergic hypothesis

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Experimental neurology 2000-06-01 End-of-life care

    Life's Journey If life is indeed a journey, then poetry must be the map that reveals all its topographic possibilitiesellipsis while science is the compass that keeps us from getting lost. -R. T. Bartus, Simple Words for Complex Lives, (c) 1998 In the nearly 20 years since the cholinergic hypothesis was initially formulated, significant progress has been achieved.

  4. Synucleins are developmentally expressed, and alpha-synuclein regulates the size of the presynaptic vesicular pool in primary hippocampal neurons

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The Journal of neuroscience : the official journal of the Society for Neuroscience 2000-05-01 Drug development

    alpha-, beta-, and gamma-Synuclein, a novel family of neuronal proteins, has become the focus of research interest because alpha-synuclein has been increasingly implicated in the pathogenesis of Parkinson's and Alzheimer's disease.

  5. Fiber diffraction of synthetic alpha-synuclein filaments shows amyloid-like cross-beta conformation

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Proceedings of the National Academy of Sciences of the United States of America 2000-04-01 Brain tissue and pathology

    Filamentous inclusions made of alpha-synuclein constitute the defining neuropathological characteristic of Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy.

  6. Fibrils formed in vitro from alpha-synuclein and two mutant forms linked to Parkinson's disease are typical amyloid

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Biochemistry 2000-03-01 Risk genes beyond APOE

    Two missense mutations in the gene encoding alpha-synuclein have been linked to rare, early-onset forms of Parkinson's disease (PD).

  7. beta-Amyloid(1-42) binds to alpha7 nicotinic acetylcholine receptor with high affinity. Implications for Alzheimer's disease pathology

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The Journal of biological chemistry 2000-02-01 Risk genes beyond APOE

    Alzheimer's disease pathology is characterized by the presence of neuritic plaques and the loss of cholinergic neurons in the brain.

  8. Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Proceedings of the National Academy of Sciences of the United States of America 2000-02-01 Risk genes beyond APOE

    The cDNAs of two new human membrane-associated aspartic proteases, memapsin 1 and memapsin 2, have been cloned and sequenced.

  9. Intraneuronal Abeta42 accumulation in human brain

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The American journal of pathology 2000-01-01 Risk genes beyond APOE

    Alzheimer's disease (AD) is characterized by the deposition of senile plaques (SPs) and neurofibrillary tangles (NFTs) in vulnerable brain regions.

  10. The alpha-synucleinopathies: Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Annals of the New York Academy of Sciences 2000-01-01 Lewy body dementia

    Parkinson's disease is the second most common neurodegenerative disease, after Alzheimer's disease.

  11. Lithium up-regulates the cytoprotective protein Bcl-2 in the CNS in vivo: a role for neurotrophic and neuroprotective effects in manic depressive illness

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. PubMed 2000-01-01 Drug development

    Although mood disorders have traditionally been conceptualized as "neurochemical disorders," considerable literature from a variety of sources demonstrates significant reductions in regional central nervous system (CNS) volume and cell numbers (both neurons and glia) in persons with mood disorders.

  12. Identification of a novel aspartic protease (Asp 2) as beta-secretase

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Molecular and cellular neurosciences 1999-12-01 Risk genes beyond APOE

    The Alzheimer's disease beta-amyloid peptide (Abeta) is produced by excision from the type 1 integral membrane glycoprotein amyloid precursor protein (APP) by the sequential actions of beta- and then gamma-secretases.

  13. Cu(II) potentiation of alzheimer abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The Journal of biological chemistry 1999-12-01 Disease mechanisms

    Oxidative stress markers as well as high concentrations of copper are found in the vicinity of Abeta amyloid deposits in Alzheimer's disease.

  14. Choline acetyltransferase: the structure, distribution and pathologic changes in the central nervous system

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Pathology international 1999-11-01 Risk factors

    The genomic structure of ChAT is unique compared with other enzymes for neurotransmitters.

  15. Activation of the L voltage-sensitive calcium channel by mitogen-activated protein (MAP) kinase following exposure of neuronal cells to beta-amyloid. MAP kinase mediates beta-amyloid-induced neurodegeneration

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The Journal of biological chemistry 1999-10-01 Drug development

    Neuronal degeneration in Alzheimer's disease (AD) has been variously attributed to increases in cytosolic calcium, reactive oxygen species, and phosphorylated forms of the microtubule-associated protein tau. beta-Amyloid (betaA), which accumulates extracellularly in AD brain, induces calcium influx in culture via the L voltage-sensitive calcium channel.

  16. Lithium at 50: have the neuroprotective effects of this unique cation been overlooked?

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Biological psychiatry 1999-10-01 Drug development

    Recent advances in cellular and molecular biology have resulted in the identification of two novel, hitherto completely unexpected targets of lithium's actions, discoveries that may have a major impact on the future use of this unique cation in biology and medicine.

  17. The role of copper in neurodegenerative disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neurobiology of disease 1999-08-01 Brain scans and imaging

    Copper is an essential trace metal which plays a fundamental role in the biochemistry of the human nervous system.

  18. Lithium protects cultured neurons against beta-amyloid-induced neurodegeneration

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. FEBS letters 1999-06-01 Drug development

    The deposition of beta-amyloid peptide (A beta), the hyperphosphorylation of tau protein and the death of neurons in certain brain regions are characteristic features of Alzheimer's disease.

  19. The A beta peptide of Alzheimer's disease directly produces hydrogen peroxide through metal ion reduction

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Biochemistry 1999-06-01 Brain tissue and pathology

    Oxidative stress markers characterize the neuropathology both of Alzheimer's disease and of amyloid-bearing transgenic mice.

  20. Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Proceedings of the National Academy of Sciences of the United States of America 1999-03-01 Risk genes beyond APOE

    Autosomal dominant forms of familial Alzheimer's disease (FAD) are associated with increased production of the amyloid beta peptide, Abeta42, which is derived from the amyloid protein precursor (APP).

  21. Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Proceedings of the National Academy of Sciences of the United States of America 1999-03-01 Risk genes beyond APOE

    Amyloid beta peptide (Abeta), the principal proteinaceous component of amyloid plaques in brains of Alzheimer's disease patients, is derived by proteolytic cleavage of the amyloid precursor protein (APP).

  22. Evidence for a physical interaction between presenilin and Notch

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Proceedings of the National Academy of Sciences of the United States of America 1999-03-01 Drug development

    Genetic analyses in Caenorhabditis elegans demonstrate that sel-12 and hop-1, homologues of the Alzheimer's disease-associated presenilin genes, modify signaling through LIN-12 and GLP-1, homologues of the Notch cell surface receptor.

  23. Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The Journal of biological chemistry 1999-03-01 Disease mechanisms

    Transgenic mice overexpressing different forms of amyloid precursor protein (APP), i.e. wild type or clinical mutants, displayed an essentially comparable early phenotype in terms of behavior, differential glutamatergic responses, deficits in maintenance of long term potentiation, and premature death.

  24. Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The Journal of biological chemistry 1998-12-01 Tau biomarkers

    Excessive cerebral accumulation of the 42-residue amyloid beta-protein (Abeta) is an early and invariant step in the pathogenesis of Alzheimer's disease.

  25. Interaction of cytosolic adaptor proteins with neuronal apolipoprotein E receptors and the amyloid precursor protein

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The Journal of biological chemistry 1998-12-01 Genetics

    Apolipoprotein E, alpha2-macroglobulin, and amyloid precursor protein (APP) are involved in the development of Alzheimer's disease.

From across this topic

10 of the 1,352 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.

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