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circadian
196 studies tagged circadian, dated 1983 to 2026-10-16. Bibliography: BibTeX (.bib) · RIS (.ris)
Newest in this topic
- Progressive neurodegeneration of the locus coeruleus drives rapid eye movement sleep fragmentation 2026-10-16
- REM sleep EEG slowing signals basal forebrain integrity in older adults with subjective and mild cognitive impairment 2026-10-02
- A systems-level model of sleep-dependent memory-consolidation failure in neurodegeneration: the spindle–slow-oscillation decoupling cascade dissociates amyloid and tau 2026-09-29
Studies
196 studies carry this tag.
Date range
1983 to 2026
Top journals
- Alzheimer's & dementia : the journal of the Alzheimer's Association 12
- bioRxiv 7
- medRxiv 7
- Journal of Alzheimer's disease : JAD 6
- Sleep 5
128 journals in all.
Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.
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Women have increased risks for both sleep disturbances and disorders and for mental health issues throughout their lives, starting in adolescence.
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Patients were followed for a median of 2.92 years.
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The global north is facing an unprecedented rise in the prevalence of neurodegenerative diseases.
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This review explores the interface between circadian timekeeping and the regulation of brain function by astrocytes.
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The aim of this review is to summarize the current evidence on the relationship between sleep and cognition and present available data reporting the impact that sleep alterations may have on cognitive functions.
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Disruptions of circadian rhythms and sleep cycles are common among neurodegenerative diseases and can occur at multiple levels.
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41/100
Although poor sleep quality and extreme sleep durations have been associated with brain atrophy and dementia, it is unclear whether sleep disturbances contribute to neural injury in the absence of neurodegeneration and cognitive impairment.
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These findings show that sleep loss alters some plasma AD biomarkers by lowering brain clearance mechanisms and needs to be taken into account when interpreting individual plasma AD biomarkers but not ratios.
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Higher ISI score was associated with greater average levels of CSF Aβ42 (per point: 30.7 pg/mL, 95% CI: 4.17-57.3, p = 0.023), as was higher WASO (per 10 min: 136 pg/mL, 95% CI: 48-223, p = 0.002) and more awakenings (per 5:123 pg/mL, 95% CI = 55-192, p < 0.001).
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The empirical study showed a U-shaped relationship between sleep duration and increased risk of cognitive impairment.
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Alzheimer's disease (AD) is considered to be the most typical form of dementia that provokes irreversible cognitive impairment.
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long baseline nighttime and 24-h sleep durations (≥9 h) as well as being persistent or becoming long sleepers during follow-up were associated with dementia incidence.
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Of the 17,668 respondents, 8,396 (47.5%) were men.
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Our aim was to determine whether the genetic liability to sleep and pain-related traits have a causal effect on risk of neurodegeneration in individuals of predominantly European ancestry.
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Sleep duration, psychiatric disorders and dementias are closely interconnected in older adults.
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Patients suffering from neurodegenerative conditions frequently report sleep complaints, such as insomnia and excessive daytime sleepiness.
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71/100
Polysomnography (PSG) studies of sleep changes in Alzheimer's disease (AD) have reported but not fully established the relationship between sleep disturbances and AD.
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Sleep duration had an inverted U-shape relationship with cognitive scores (P <.001); and sleep quality had a positive linear relationship with cognitive scores (P <.001).
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This article provides a current review of the literature examining caffeine use in older adults.
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Short sleep duration has been linked to the development of neurocognitive disorders.
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The hypocretins (Hcrts), also known as orexins, are two neuropeptides produced exclusively in the lateral hypothalamus.
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Sleep plays an important role in homeostasis, brain plasticity, clearance of neurotoxins, cognition, memory, concentration, performance, and the regulation of the temperature, endocrine and immunological systems.
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Prevalence of insomnia was 14%, 16%, and 11% for normal, MCI, and dementia groups.
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A growing number of studies in animal models have highlighted the link between sleep disorders and Alzheimer's disease (AD).
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Narcolepsy type 1 is strongly associated with human leukocyte antigen (HLA)-DQB1*06:02; however, no significant associations between IH and HLA alleles have been reported.
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Decades of research has established a shift from an "eveningness" preference to a "morningness" preference with increasing age.
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Sleep disorders are common in patients with Alzheimer's disease, and can even occur in patients with amnestic mild cognitive impairment, which appears before Alzheimer's disease.
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Sleep plays a critical role in homeostasis of the body and mind.
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During a median of 10.8 years follow-up, sleeping more or fewer than 7 hours was associated with a higher dementia risk (hazard ratio [HR] for 5 vs 7 hours: 1.35, 95% confidence interval [CI] 1.11-1.64; HR for 9 vs 7 hours: 1.59; 95% CI 1.37-1.85) as was daytime napping (HR for often/all of the time vs never/rarely: 1.67; 95% CI 1.37-2.03).
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Sedative antidepressants are commonly used drugs in the treatment of insomnia.
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Older adults who do not sleep well frequently have difficulty sustaining attention, display slower physical response times, and have memory issues that may contribute to depression or early dementia.
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Around 40% of dementia risk is attributable to modifiable risk factors such as physical inactivity, hypertension, diabetes and obesity.
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A relationship between sleep disorders and cognitive dysfunctions was reported in Parkinson's Disease (PD), however, some studies did not confirm the link.
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Insomnia is defined as difficulties of initiating and maintaining sleep, early awakening and poor subjective sleep quality despite adequate opportunity and circumstances for sleep with impairment of daytime performance.
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Our systematic review shows evidence for disruptions in (night-time) melatonin levels in AD as compared to age-matched controls.
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41/100
We have entered an era of a steep increase in the absolute and relative number of older people.
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Disruptions of sleep and circadian rhythms are among the most debilitating symptoms in patients with neurodegenerative diseases.
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50/100
The Pittsburgh Sleep Quality Index (PSQI) total score was significantly negatively correlated with Montreal Cognitive Assessment (MoCA) score (p = 0.0176).
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Sleep dysfunction has been identified in the pathophysiology of Alzheimer's disease (AD); however, the role and mechanism of circadian rhythm dysfunction is less well understood.
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This cycle is challenging to study, as its bidirectional nature renders cause difficult to disentangle from effect.
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The glymphatic system is a "pseudo-lymphatic" perivascular network distributed throughout the brain, responsible for replenishing as well as cleansing the brain.
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We observed a dose-response association between higher alcohol consumption in 2006 and worse sleep quality in 2012 (Ptrend < 0·001), after adjusting for age, sex, socio-economic status, smoking status, physical activity, obesity, plasma lipid profiles, diabetes and hypertension.
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Insomnia and hypersomnia are conditions with multifactorial causes that can be difficult to treat.
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Greater daytime sleepiness was associated with higher CSF indicators of amyloid deposition in female patients.
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Serious OSAS and short sleep duration are associated with a high risk of developing dementia.
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The number of patients with Alzheimer's disease (AD) is increasing significantly.
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In recent years, the idea that sleep is critical for cognitive processing has gained strength.
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RECENT FINDINGS: Some studies investigated the efficacy and safety of hypnotic agents as ramelteon and mirtazapine to treat sleep disorders in AD but no significant therapeutic effects have been observed.
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Of 285 participants randomized (suvorexant, N = 142; placebo, N = 143), 277 (97%) completed the trial (suvorexant, N = 136; placebo, N = 141).
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Methylation across all the CpGs strongly correlated with each other.
From across this tag
9 of the 196 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 9. The same 9 appear here every time.
- Insomnia in Older Adults
- Sleep and circadian abnormalities precede cognitive deficits in R521C FUS knockin rats
- The role of circadian clock genes in mental disorders
- Altered resting-state functional connectivity patterns in late middle-aged and older adults with obstructive sleep apnea
- Cross-sectional and longitudinal associations between sleep disturbances and psycho-affective symptoms in older adults: influence of amyloid positivity
- Repeated mild traumatic brain injury does not affect sleep or epileptiform activity one-month post-injury in a knock-in mouse model of Alzheimer’s disease
- Night-to-night REM sleep variability: a relevant marker of early amyloid-β deposition
- Sleep: A Novel Mechanistic Pathway, Biomarker, and Treatment Target in the Pathology of Alzheimer's Disease?
- Role of melatonin in Alzheimer-like neurodegeneration