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Home › Research › Topics › apoe

apoe

1,350 studies tagged apoe, dated 1982-09-01 to 2026-10-18. Bibliography: BibTeX (.bib) · RIS (.ris)

Newest in this topic

  1. Evidence for Reduced Somatic T-Cell Receptor Sequence Diversity Profiles Among Midwestern Amish in an Aging Cohort Study 2026-10-18
  2. Gantenerumab reduces brain amyloid-β proteoforms: Biochemical evaluation in dominantly inherited Alzheimer disease 2026-09-29
  3. Genetic Insights Into Protective Effects of GLP-1 Receptor Agonists on Stroke and Alzheimer Disease Across Ancestries 2026-09-25

Studies

1,350 studies carry this tag.

Date range

1982 to 2026

Top journals

  • Neurology 92
  • The Journal of biological chemistry 67
  • Proceedings of the National Academy of Sciences of the United States of America 47
  • Archives of neurology 43
  • JAMA neurology 36

372 journals in all.

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

  1. Neutrophil hyperactivation correlates with Alzheimer's disease progression

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. Annals of neurology 2018-02-01 Mild cognitive impairment

    Our results indicate that the inflammatory properties of circulating neutrophils shift as the percentage of aged neutrophils expands in patients with AD-changes that may play an instrumental role in establishing systemic chronic inflammation.

  2. Amyloid β causes excitation/inhibition imbalance through dopamine receptor 1-dependent disruption of fast-spiking GABAergic input in anterior cingulate cortex

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Scientific reports 2018-01-10 Disease mechanisms

    Alzheimer's disease (AD) is the most common cause of dementia in the elderly.

  3. Immune-related genetic enrichment in frontotemporal dementia: An analysis of genome-wide association studies

    ✓ Peer-reviewed alzhub usefulness score 71 out of 100. PLoS medicine 2018-01-09 Inflammation and the immune system

    We found up to 270-fold genetic enrichment between FTD and RA, up to 160-fold genetic enrichment between FTD and UC, up to 180-fold genetic enrichment between FTD and T1D, and up to 175-fold genetic enrichment between FTD and CeD.

  4. Oxidative Stress, Amyloid-β Peptide, and Altered Key Molecular Pathways in the Pathogenesis and Progression of Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. Journal of Alzheimer's disease : JAD 2018-01-01 Mild cognitive impairment

    Oxidative stress is implicated in the pathogenesis and progression of Alzheimer's disease (AD) and its earlier stage, amnestic mild cognitive impairment (aMCI).

  5. The Amygdala as a Locus of Pathologic Misfolding in Neurodegenerative Diseases

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. Journal of neuropathology and experimental neurology 2018-01-01 Brain scans and imaging

    Over the course of most common neurodegenerative diseases the amygdala accumulates pathologically misfolded proteins.

  6. The role of microbial amyloid in neurodegeneration

    ✓ Peer-reviewed alzhub usefulness score 52 out of 100. PLoS pathogens 2017-12-21 Inflammation and the immune system

    It has become apparent that the intestinal microbiota orchestrates important aspects of our metabolism, immunity, and development.

  7. Comparative profiling of cortical gene expression in Alzheimer's disease patients and mouse models demonstrates a link between amyloidosis and neuroinflammation

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. Scientific reports 2017-12-19 TREM2 and immune genetics

    Alzheimer's disease (AD) is the most common form of dementia, characterized by accumulation of amyloid β (Aβ) and neurofibrillary tangles.

  8. Involvement of Astrocytes in Alzheimer's Disease from a Neuroinflammatory and Oxidative Stress Perspective

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Frontiers in molecular neuroscience 2017-12-19 Inflammation and the immune system

    Alzheimer disease (AD) is a frequent and devastating neurodegenerative disease in humans, but still no curative treatment has been developed.

  9. Aβ mediates F-actin disassembly in dendritic spines leading to cognitive deficits in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. The Journal of neuroscience : the official journal of the Society for Neuroscience 2017-12-15 Mild cognitive impairment

    Dendritic spine structure is defined by filamentous actin (F-actin) and we observed depolymerization of synaptosomal F-actin accompanied by increased globular-actin (G-actin) at as early as 1 month of age in a mouse model of AD (APPswe/PS1ΔE9, male mice).

  10. Alzheimer's Disease: The Role of Microglia in Brain Homeostasis and Proteopathy

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Frontiers in neuroscience 2017-12-12 TREM2 and immune genetics

    Brain aging is central to late-onset Alzheimer's disease (LOAD), although the mechanisms by which it occurs at protein or cellular levels are not fully understood.

  11. MiR-124 acts as a target for Alzheimer's disease by regulating BACE1

    ⚠ Retracted — do not rely on it alzhub usefulness score 16 out of 100. Oncotarget 2017-12-09 Risk genes beyond APOE

    Although large numbers of microRNAs (miRNAs) expressed in Alzheimer disease (AD) have been detected, their functions and mechanisms of regulation remain to be fully clarified.

  12. Age-Dependent Effects of apoE Reduction Using Antisense Oligonucleotides in a Model of β-amyloidosis

    ✓ Peer-reviewed alzhub usefulness score 52 out of 100. Neuron 2017-12-01 Genetics

    The apolipoprotein E (APOE) gene is the strongest genetic risk factor for late-onset Alzheimer disease.

  13. Insulin Resistance and Alzheimer's Disease: Bioenergetic Linkages

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. Frontiers in aging neuroscience 2017-10-31 Risk factors

    Metabolic dysfunction is a well-established feature of Alzheimer's disease (AD), evidenced by brain glucose hypometabolism that can be observed potentially decades prior to the development of AD symptoms.

  14. Earliest accumulation of β-amyloid occurs within the default-mode network and concurrently affects brain connectivity

    ✓ Peer-reviewed alzhub usefulness score 61 out of 100. Nature Communications 2017-10-25 Brain scans and imaging

    It is not known exactly where amyloid-β (Aβ) fibrils begin to accumulate in individuals with Alzheimer's disease (AD).

  15. Increased localization of APP-C99 in mitochondria-associated ER membranes causes mitochondrial dysfunction in Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 51 out of 100. The EMBO journal 2017-10-10 Brain scans and imaging

    In the amyloidogenic pathway associated with Alzheimer disease (AD), the amyloid precursor protein (APP) is cleaved by β-secretase to generate a 99-aa C-terminal fragment (C99) that is then cleaved by γ-secretase to generate the β-amyloid (Aβ) found in senile plaques.

  16. N-truncated Aβ4-x peptides in sporadic Alzheimer's disease cases and transgenic Alzheimer mouse models

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Alzheimer's research & therapy 2017-10-04 Down syndrome and Alzheimer's

    The findings of this study are consistent with previous reports demonstrating a high aggregation propensity of Aβ 4-x peptides and suggest an important role of these N-truncated Aβ species in the process of amyloidogenesis and plaque core formation.

  17. Apolipoprotein E Genotype and Sex Risk Factors for Alzheimer Disease: A Meta-analysis

    ✓ Peer-reviewed alzhub usefulness score 74 out of 100. JAMA neurology 2017-10-01 Genetics

    Contrary to long-standing views, men and women with the APOE ε3/ε4 genotype have nearly the same odds of developing AD from age 55 to 85 years, but women have an increased risk at younger ages.

  18. Genetic, Transcriptome, Proteomic, and Epidemiological Evidence for Blood-Brain Barrier Disruption and Polymicrobial Brain Invasion as Determinant Factors in Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Journal of Alzheimer's disease reports 2017-09-28 TREM2 and immune genetics

    Diverse pathogens are detected in Alzheimer's disease (AD) brains.

  19. Apolipoprotein E4 inhibits autophagy gene products through direct, specific binding to CLEAR motifs

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. Alzheimer's & dementia : the journal of the Alzheimer's Association 2017-09-22 Genetics

    ApoE4-CLEAR interactions may account for suppressed autophagy in APOE ɛ4/ɛ4 carriers and, in this way, contribute to earlier AD onset.

  20. Early-Onset Alzheimer Disease and Candidate Risk Genes Involved in Endolysosomal Transport

    ✓ Peer-reviewed alzhub usefulness score 56 out of 100. JAMA neurology 2017-09-01 TREM2 and immune genetics

    Mutations in APP, PSEN1, and PSEN2 lead to early-onset Alzheimer disease (EOAD) but account for only approximately 11% of EOAD overall, leaving most of the genetic risk for the most severe form of Alzheimer disease unexplained.

  21. Key Aging-Associated Alterations in Primary Microglia Response to Beta-Amyloid Stimulation

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Frontiers in aging neuroscience 2017-08-31 TREM2 and immune genetics

    Alzheimer's disease (AD) is characterized by a progressive cognitive decline and believed to be driven by the self-aggregation of amyloid-β (Aβ) peptide into oligomers and fibrils that accumulate as senile plaques.

  22. Diversity of Amyloid-beta Proteoforms in the Alzheimer's Disease Brain

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. Scientific reports 2017-08-25 Disparities

    Amyloid-beta (Aβ) plays a key role in the pathogenesis of Alzheimer's disease (AD), but little is known about the proteoforms present in AD brain.

  23. APOE genotype and early β-amyloid accumulation in older adults without dementia

    ✓ Peer-reviewed alzhub usefulness score 66 out of 100. Neurology 2017-08-09 Prevention and risk

    APOE ε4 carriage and older age were predictors of longitudinal Aβ accumulation within the Aβ- group but not the Aβ+ group.

  24. Contribution to Alzheimer's disease risk of rare variants in TREM2, SORL1, and ABCA7 in 1779 cases and 1273 controls

    ✓ Peer-reviewed alzhub usefulness score 51 out of 100. Neurobiology of aging 2017-07-14 Genetics

    We performed whole-exome and whole-genome sequencing in 927 late-onset Alzheimer disease (LOAD) cases, 852 early-onset AD (EOAD) cases, and 1273 controls from France.

  25. The Role of Microglia in Retinal Neurodegeneration: Alzheimer's Disease, Parkinson, and Glaucoma

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Frontiers in aging neuroscience 2017-07-06 Lewy body dementia

    Microglia, the immunocompetent cells of the central nervous system (CNS), act as neuropathology sensors and are neuroprotective under physiological conditions.

  26. [O1–04–03]: NEIGHBORHOOD SOCIOECONOMIC CONTEXTUAL DISADVANTAGE, BASELINE COGNITION AND ALZHEIMER's DISEASE BIOMARKERS IN THE WISCONSIN REGISTRY FOR ALZHEIMER's PREVENTION (WRAP) STUDY

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Alzheimer s & Dementia 2017-07-01 Risk factors

    Neighborhood disadvantage is associated with education, health behaviors and mortality.

  27. Effect of high fat diet on phenotype, brain transcriptome and lipidome in Alzheimer's model mice

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. Scientific reports 2017-06-27 TREM2 and immune genetics

    We examined the effect of chronic high fat diet (HFD) on amyloid deposition and cognition of 12-months old APP23 mice, and correlated the phenotype to brain transcriptome and lipidome.

  28. Advanced Glycation End-Products Are Associated With the Presence and Severity of Paratonia in Early Stage Alzheimer Disease

    ✓ Peer-reviewed alzhub usefulness score 53 out of 100. Journal of the American Medical Directors Association 2017-05-27 Disease mechanisms

    From the 144 participants (56.3% female and 43.7% male, with a mean [standard deviation] age of 80.7 [7.7] years), 118 participants were available for final follow-up.

  29. Late onset Alzheimer's disease genetics implicates microglial pathways in disease risk

    ✓ Peer-reviewed alzhub usefulness score 54 out of 100. Molecular neurodegeneration 2017-05-26 TREM2 and immune genetics

    Alzheimer's disease (AD) is a highly heritable complex disease with no current effective prevention or treatment.

  30. Association between advanced glycation end-products and functional performance in Alzheimer's disease and mixed dementia

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. International psychogeriatrics 2017-05-25 Disease mechanisms

    This study indicates that high AGE levels could be a contributing factor to impaired mobility but lacks evidence for an association with ADL decline in people with early stage AD or mixed dementia.

  31. Characterization of pathogenic SORL1 genetic variants for association with Alzheimer's disease: a clinical interpretation strategy

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. European journal of human genetics : EJHG 2017-05-24 Genetics

    Accumulating evidence suggests that genetic variants in the SORL1 gene are associated with Alzheimer disease (AD), but a strategy to identify which variants are pathogenic is lacking.

  32. Brain Perivascular Macrophages Initiate the Neurovascular Dysfunction of Alzheimer Aβ Peptides

    ✓ Peer-reviewed alzhub usefulness score 52 out of 100. Circulation research 2017-05-17 Risk genes beyond APOE

    Increasing evidence indicates that alterations of the cerebral microcirculation may play a role in Alzheimer disease, the leading cause of late-life dementia.

  33. Peritoneal dialysis reduces amyloid-beta plasma levels in humans and attenuates Alzheimer-associated phenotypes in an APP/PS1 mouse model

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Acta neuropathologica 2017-05-05 Disease mechanisms

    Clearance of amyloid-beta (Aβ) from the brain is an important therapeutic strategy for Alzheimer's disease (AD).

  34. ApoE influences regional white-matter axonal density loss in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 53 out of 100. Neurobiology of aging 2017-05-03 Genetics

    Mechanisms underlying phenotypic heterogeneity in young onset Alzheimer disease (YOAD) are poorly understood.

  35. Binding Sites for Amyloid-β Oligomers and Synaptic Toxicity

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Cold Spring Harbor perspectives in medicine 2017-05-01 Disease mechanisms

    In Alzheimer's disease (AD), insoluble and fibrillary amyloid-β (Aβ) peptide accumulates in plaques.

  36. Obesity Accelerates Alzheimer-Related Pathology in APOE4 but not APOE3 Mice

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. eNeuro 2017-05-01 Genetics

    Alzheimer's disease (AD) risk is modified by both genetic and environmental risk factors, which are believed to interact to cooperatively modify pathogenesis.

  37. Not just amyloid: physiological functions of the amyloid precursor protein family

    ✓ Peer-reviewed alzhub usefulness score 53 out of 100. Nature reviews. Neuroscience 2017-03-31 Risk genes beyond APOE

    Amyloid precursor protein (APP) gives rise to the amyloid-β peptide and thus has a key role in the pathogenesis of Alzheimer disease.

  38. APP, PSEN1, and PSEN2 mutations in early-onset Alzheimer disease: A genetic screening study of familial and sporadic cases

    ✓ Peer-reviewed alzhub usefulness score 64 out of 100. PLoS medicine 2017-03-28 Risk genes beyond APOE

    Amyloid protein precursor (APP), presenilin-1 (PSEN1), and presenilin-2 (PSEN2) mutations cause autosomal dominant forms of early-onset Alzheimer disease (AD-EOAD).

  39. Fine-mapping of the human leukocyte antigen locus as a risk factor for Alzheimer disease: A case-control study

    ✓ Peer-reviewed alzhub usefulness score 64 out of 100. PLoS medicine 2017-03-28 Genetics

    Secondary analysis suggested that this effect may be driven primarily by individuals who are negative for the established AD genetic risk factor, apolipoprotein E (APOE) ɛ4.

  40. Increased Plasma Beta-Secretase 1 May Predict Conversion to Alzheimer's Disease Dementia in Individuals With Mild Cognitive Impairment

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. Biological psychiatry 2017-03-27 Mild cognitive impairment

    Plasma BACE1 activity is significantly increased in MCI converters and patients with probable AD.

  41. Apolipoprotein E4 and Insulin Resistance Interact to Impair Cognition and Alter the Epigenome and Metabolome

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Scientific reports 2017-03-08 Clinical safety

    Apolipoprotein E4 (E4) and type 2 diabetes are major risk factors for cognitive decline and late onset Alzheimer's disease (AD).

  42. Association of Docosahexaenoic Acid Supplementation With Alzheimer Disease Stage in Apolipoprotein E ε4 Carriers: A Review

    ✓ Peer-reviewed alzhub usefulness score 51 out of 100. JAMA neurology 2017-03-01 Genetics

    High-dose DHA supplementation in APOE4 carriers before the onset of AD dementia can be a promising approach to decrease the incidence of AD.

  43. Transethnic genome-wide scan identifies novel Alzheimer's disease loci

    ✓ Peer-reviewed alzhub usefulness score 53 out of 100. Alzheimer's & dementia : the journal of the Alzheimer's Association 2017-02-07 Genetics

    Our findings highlight the value of transethnic studies for identifying novel AD susceptibility loci.

  44. Apolipoprotein E metabolism and functions in brain and its role in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Current opinion in lipidology 2017-02-01 TREM2 and immune genetics

    APOE4 genotype is the strongest genetic risk factor for Alzheimer's disease.

  45. Particulate air pollutants, APOE alleles and their contributions to cognitive impairment in older women and to amyloidogenesis in experimental models

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. Translational psychiatry 2017-01-31 How common it is

    Exposure to particulate matter (PM) in the ambient air and its interactions with APOE alleles may contribute to the acceleration of brain aging and the pathogenesis of Alzheimer's disease (AD).

  46. Endo-lysosomal and autophagic dysfunction: a driving factor in Alzheimer's disease?

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Journal of neurochemistry 2017-01-23 Clinical safety

    Alzheimer's disease (AD) is the most common cause of dementia, and its prevalence will increase significantly in the coming decades.

  47. TOMM40'523 variant and cognitive decline in older persons with APOE ε3/3 genotype

    ✓ Peer-reviewed alzhub usefulness score 61 out of 100. Neurology 2017-01-20 Genetics

    Our data reveal an association of APOE ε3/3- TOMM40 '523 haplotypes with cognitive decline in community-based older persons such that the S/S poly-T genotype is related to faster cognitive decline, primarily in the domains of episodic and semantic memory.

  48. Association of Amyloid Pathology With Myelin Alteration in Preclinical Alzheimer Disease

    ✓ Peer-reviewed alzhub usefulness score 61 out of 100. JAMA neurology 2017-01-01 Prevention and risk

    These findings suggest amyloid pathologies significantly influence white matter and that these abnormalities may signify an early feature of the disease process.

  49. Association of Brain Amyloid-β With Slow Gait in Elderly Individuals Without Dementia: Influence of Cognition and Apolipoprotein E ε4 Genotype

    ✓ Peer-reviewed alzhub usefulness score 60 out of 100. JAMA neurology 2017-01-01 Genetics

    Among the 183 study participants, mean (SD) age was 85.5 (3) years, 76 were women (41.5%), and 177 were white (96.7%).

  50. Association of Perivascular Localization of Aquaporin-4 With Cognition and Alzheimer Disease in Aging Brains

    ✓ Peer-reviewed alzhub usefulness score 56 out of 100. JAMA neurology 2017-01-01 Caregiving

    In this study, altered AQP4 expression was associated with aging brains.

From across this tag

10 of the 1,348 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.

All topic tags with their study counts