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There's Something Wrong with my MAM; the ER-Mitochondria Axis and Neurodegenerative Diseases
Paillusson S, Stoica R, Gomez-Suaga P, Lau DHW, Mueller S, Miller T, Miller CCJ.. Trends in neurosciences, 2016-02-15
Topic: Brain proteins, microglia and lab models
Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis with associated frontotemporal dementia (ALS/FTD) are major neurodegenerative diseases for which there are no cures. All are characterised by damage to several seemingly disparate cellular processes. The broad nature of this damage makes understanding pathogenic mechanisms and devising new treatments difficult. Can the different damaged functions be linked together in a common disease pathway and which damaged function should be targeted for therapy? Many functions damaged in neurodegenerative diseases are regulated by communications that mitochondria make with a specialised region of the endoplasmic reticulum (ER; mitochondria-associated ER membranes or 'MAM'). Moreover, several recent studies have shown that disturbances to ER-mitochondria contacts occur in neurodegenerative diseases. Here, we review these findings.
Key findings
- Moreover, several recent studies have shown that disturbances to ER-mitochondria contacts occur in neurodegenerative diseases.
Why it matters
This review discusses evidence that disturbances in contacts between the endoplasmic reticulum and mitochondria occur in Alzheimer's disease, Parkinson's disease, and ALS/FTD. It raises the question of which damaged function to target for therapy but reports no treatment or cure.
Study details
- Evidence strengthLow
How this study scored 48/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Trends in neurosciences) |
| Journal's citation record | 3 / 4 | Trends in Neurosciences: journal h-index 439 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2016 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 6 / 7 | Cited 442 times (OpenAlex, 2026-10-10) |
| Citations per year | 4 / 5 | 36.8 citations a year over 12 year(s) since 2016 |
| Impact for its field and year | 3 / 6 | Cited 3.2× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 1 / 6 | Cited by 2 other studies in this library |
| Still being cited | 3 / 4 | Cited 94 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Christopher C.J. Miller: h-index 61 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | King's College London: institution h-index 1,348 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 26899735) |
| Free to read | 2 / 2 | Free to read |
| Total | 48 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1016/j.tins.2016.01.008
- PubMed: 26899735
- Original source →
- Free full text: Trends in Neurosciences →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 7 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
APA 7th
Paillusson, S., Stoica, R., Gomez-Suaga, P., Lau, D. H. W., Mueller, S., Miller, T., et al. (2016). There's Something Wrong with my MAM; the ER-Mitochondria Axis and Neurodegenerative Diseases. Trends in neurosciences. https://doi.org/10.1016/j.tins.2016.01.008
Vancouver
Paillusson S, Stoica R, Gomez-Suaga P, Lau DHW, Mueller S, Miller T, et al. There's Something Wrong with my MAM; the ER-Mitochondria Axis and Neurodegenerative Diseases. Trends in neurosciences. 2016. doi:10.1016/j.tins.2016.01.008. PMID: 26899735.
BibTeX
@article{paillusson2016-26899735,
author = {Paillusson, S. and Stoica, R. and Gomez-Suaga, P. and Lau, D. H. W. and Mueller, S. and Miller, T. and Miller, C. C. J.},
title = {{There's Something Wrong with my MAM; the ER-Mitochondria Axis and Neurodegenerative Diseases}},
journal = {Trends in neurosciences},
year = {2016},
doi = {10.1016/j.tins.2016.01.008},
pmid = {26899735},
url = {https://doi.org/10.1016/j.tins.2016.01.008}
}
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Later studies that cite this one
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