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Mitochondria-associated ER membranes and Alzheimer disease
Area-Gomez E, Schon EA.. Current opinion in genetics & development, 2016-05-25
Topic: Amyloid, tau and blood-test diagnosis
The series of events underlying the pathogenesis of Alzheimer disease (AD) in unknown. The most widely accepted hypothesis is called the amyloid cascade, based on the observation that the brains of AD patients contain high levels of extracellular plaques, composed mainly of β-amyloid (Aβ), and intracellular tangles, composed of hyperphosphorylated forms of the microtubule-associated protein tau. However, AD is also characterized by other features, including aberrant cholesterol, phospholipid, and calcium metabolism, and mitochondrial dysfunction, all ostensibly unrelated to plaque and tangle formation.
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APA 7th
Area-Gomez, E., & Schon, E. A. (2016). Mitochondria-associated ER membranes and Alzheimer disease. Current opinion in genetics & development. https://doi.org/10.1016/j.gde.2016.04.006
Vancouver
Area-Gomez E, Schon EA. Mitochondria-associated ER membranes and Alzheimer disease. Current opinion in genetics & development. 2016. doi:10.1016/j.gde.2016.04.006. PMID: 27235807.
BibTeX
@article{areagomez2016-27235807,
author = {Area-Gomez, E. and Schon, E. A.},
title = {{Mitochondria-associated ER membranes and Alzheimer disease}},
journal = {Current opinion in genetics \& development},
year = {2016},
doi = {10.1016/j.gde.2016.04.006},
pmid = {27235807},
url = {https://doi.org/10.1016/j.gde.2016.04.006}
}
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Key findings
- The most widely accepted hypothesis is called the amyloid cascade, based on the observation that the brains of AD patients contain high levels of extracellular plaques, composed mainly of β-amyloid (Aβ), and intracellular tangles, composed of hyperphosphorylated forms of the microtubule-associated protein tau.
- However, AD is also characterized by other features, including aberrant cholesterol, phospholipid, and calcium metabolism, and mitochondrial dysfunction, all ostensibly unrelated to plaque and tangle formation.
- Notably, these 'other' aspects of AD pathology are functions related to mitochondria-associated ER membranes (MAM), a subdomain of the endoplasmic reticulum (ER) that is apposed to, and communicates with, mitochondria.
- Given the potential relationship between MAM and AD, we explored the possibility that perturbed MAM function might play a role in AD pathogenesis.
Why it matters
This review discusses mitochondria-associated ER membranes and notes that Alzheimer's disease involves features such as altered cholesterol, phospholipid and calcium metabolism and mitochondrial dysfunction alongside plaques and tangles. It is a discussion of possible mechanisms and does not report a treatment, cure or prevention.
New to this subject? Start with our plain-English guide: Genetics →
Study details
- Evidence strengthLow
How this study scored 44/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Current opinion in genetics & development) |
| Journal's citation record | 2 / 4 | Current Opinion in Genetics & Development: journal h-index 242 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2016 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 185 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 15.4 citations a year over 12 year(s) since 2016 |
| Impact for its field and year | 3 / 6 | Cited 3.3× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 3 other studies in this library |
| Still being cited | 2 / 4 | Cited 33 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Eric A. Schon: h-index 95 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | Columbia University: institution h-index 1,824 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 27235807) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 44 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1016/j.gde.2016.04.006
- PubMed: 27235807
- Original source →
- Free full text: Current Opinion in Genetics & Development →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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