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Tau and atrophy: domain-specific relationships with cognition
Leonardino A Digma, John R Madsen, Emilie T Reas, Anders M Dale, James B Brewer, Sarah J Banks, Alzheimer’s Disease Neuroimaging Initiative. Alzheimer's research & therapy, 2019-07-27
Topic: Brain imaging, connectivity and assessment
FTP and thickness were differentially related to cognitive performance in several domains. FTP-cognition associations were more widespread than thickness-cognition associations. Further, FTP-cognition patterns reflected cortical systems that underlie different aspects of cognition. Our findings indicate that AD-related decline in domain-specific cognitive performance reflects underlying progression of tau and atrophy into associated brain circuits. They also suggest that tau-PET may have better sensitivity to this decline than MRI-derived measures of cortical thickness.
Key findings
- FTP and thickness were differentially related to cognitive performance in several domains.
- FTP-cognition associations were more widespread than thickness-cognition associations.
- Further, FTP-cognition patterns reflected cortical systems that underlie different aspects of cognition.
- Our findings indicate that AD-related decline in domain-specific cognitive performance reflects underlying progression of tau and atrophy into associated brain circuits.
- They also suggest that tau-PET may have better sensitivity to this decline than MRI-derived measures of cortical thickness.
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Study details
- Evidence strengthLow
How this study scored 39/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 22 of the 56 points we could judge it on, which is 39 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Alzheimer's research & therapy) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2019 — within 10 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 31351484) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 22 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 22 of the 56 points we could judge it on is 39 out of 100. |
| Total | 39 / 100 | — |
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Read the original
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Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 7 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
APA 7th
Digma, L. A., Madsen, J. R., Reas, E. T., Dale, A. M., Brewer, J. B., Banks, S. J., et al. (2019). Tau and atrophy: domain-specific relationships with cognition. Alzheimer's research & therapy. https://doi.org/10.1186/s13195-019-0518-8
Vancouver
Digma LA, Madsen JR, Reas ET, Dale AM, Brewer JB, Banks SJ, et al. Tau and atrophy: domain-specific relationships with cognition. Alzheimer's research & therapy. 2019. doi:10.1186/s13195-019-0518-8. PMID: 31351484.
BibTeX
@article{digma2019-31351484,
author = {Digma, Leonardino A and Madsen, John R and Reas, Emilie T and Dale, Anders M and Brewer, James B and Banks, Sarah J and {Alzheimer’s Disease Neuroimaging Initiative}},
title = {{Tau and atrophy: domain-specific relationships with cognition}},
journal = {Alzheimer's research \& therapy},
year = {2019},
doi = {10.1186/s13195-019-0518-8},
pmid = {31351484},
url = {https://doi.org/10.1186/s13195-019-0518-8}
}
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