Home › Research › Cognitive tests and assessment
Slower speed-of-processing of cognitive tasks is associated with presence of the apolipoprotein epsilon4 allele
O'Hara R, Sommer B, Way N, Kraemer HC, Taylor J, Murphy G.. Journal of psychiatric research, 2007-01-23
Topic: Brain proteins, microglia and lab models
Detection of preclinical cognitive deficits is important for identifying those at greatest risk for such disorders as Alzheimer's disease. However, available neuropsychological measures may not be sufficiently sensitive to preclinical cognitive impairment, particularly in high functioning or younger older adults. This study utilizes a battery of computerized cognitive tests (Cognometer) designed to provide a more sensitive measure of age-related cognitive performance by incorporating speed-of-processing components. Fifty-one community-dwelling older adults were administered the Cognometer battery, which incorporates speed-of-processing components into measures of verbal, spatial and working memory, attention, and visuo-spatial ability. Performance of 18 subjects with the epsilon4 allele was compared to that of 33 subjects without the epsilon4 allele. A brief battery of standard neuropsychological measures was also administered. No significant differences were observed between the two groups with respect to performance on any of the neuropsychological measures. However, with respect to the Cognometer battery, individuals with the epsilon4 allele were significantly slower in performing all the cognitive tasks, with the exception of the visuo-spatial task. With respect to performance, the two genotype groups did not differ significantly except on immediate memory, with the epsilon4 group exhibiting increased errors. Overall, the epsilon4 group was significantly slower in performing all of the Cognometer memory tasks. These findings provide continued support for the negative impact of the epsilon4 allele on cognition and further suggest that speed-of-processing during memory tasks may have the potential to detect subtle cognitive deficits.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
O'Hara, R., Sommer, B., Way, N., Kraemer, H. C., Taylor, J., & Murphy, G. (2008). Slower speed-of-processing of cognitive tasks is associated with presence of the apolipoprotein epsilon4 allele. Journal of psychiatric research. https://doi.org/10.1016/j.jpsychires.2006.12.001
Vancouver
O'Hara R, Sommer B, Way N, Kraemer HC, Taylor J, Murphy G. Slower speed-of-processing of cognitive tasks is associated with presence of the apolipoprotein epsilon4 allele. Journal of psychiatric research. 2008. doi:10.1016/j.jpsychires.2006.12.001. PMID: 17250852.
BibTeX
@article{ohara2008-17250852,
author = {O'Hara, R. and Sommer, B. and Way, N. and Kraemer, H. C. and Taylor, J. and Murphy, G.},
title = {{Slower speed-of-processing of cognitive tasks is associated with presence of the apolipoprotein epsilon4 allele}},
journal = {Journal of psychiatric research},
year = {2008},
doi = {10.1016/j.jpsychires.2006.12.001},
pmid = {17250852},
url = {https://doi.org/10.1016/j.jpsychires.2006.12.001}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Key findings
- Performance of 18 subjects with the epsilon4 allele was compared to that of 33 subjects without the epsilon4 allele.
- No significant differences were observed between the two groups with respect to performance on any of the neuropsychological measures.
- However, with respect to the Cognometer battery, individuals with the epsilon4 allele were significantly slower in performing all the cognitive tasks, with the exception of the visuo-spatial task.
- With respect to performance, the two genotype groups did not differ significantly except on immediate memory, with the epsilon4 group exhibiting increased errors.
- Overall, the epsilon4 group was significantly slower in performing all of the Cognometer memory tasks.
Study details
- Participants18
- Evidence strengthLow
How this study scored 43/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multi-centre collaboration, so those were left out: it earned 25 of the 58 points we could judge it on, which is 43 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of psychiatric research) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2008 — within 20 year(s) of the newest study here |
| Sample size | 1 / 4 | 18 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 17250852) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 25 / 58 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 25 of the 58 points we could judge it on is 43 out of 100. |
| Total | 43 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
Free copy unknown: no free-copy check has an answer for this record yet. That does not mean it is paywalled.
Related studies in Cognitive tests and assessment
Also tagged “apolipoprotein”
2 studies in the library carry the topic tag “apolipoprotein”; these are this study's neighbours in a fixed, alphabetical-by-hash tour of them, not the closest in content. All 2 tagged studies.