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Cognitive reserve and clinical expression of Alzheimer's disease: evidence and implications for brain PET imaging
Silvia Morbelli, Flavio Nobili. American journal of nuclear medicine and molecular imaging, 2014-04-25
Topic: Brain imaging, connectivity and assessment
Cognitive reserve (CR) refers to the hypothesized capacity of an adult brain to cope with brain damage in order to minimize symptomatology. The present review is focused on the contribution of brain PET in the understanding of the influence of CR on the disassociation between cognition and degree of Alzheimer's disease (AD) pathology. Theories for the explanation CR-related mechanism as well as PET imaging evidence for the existence of CR are described. Moreover functional imaging studies investigating specific networks for CR both in healthy subjects and AD patients are discussed. Finally implications for amyloid PET imaging are presented.
Key findings
- Cognitive reserve (CR) refers to the hypothesized capacity of an adult brain to cope with brain damage in order to minimize symptomatology.
- The present review is focused on the contribution of brain PET in the understanding of the influence of CR on the disassociation between cognition and degree of Alzheimer's disease (AD) pathology.
- Theories for the explanation CR-related mechanism as well as PET imaging evidence for the existence of CR are described.
- Moreover functional imaging studies investigating specific networks for CR both in healthy subjects and AD patients are discussed.
- Finally implications for amyloid PET imaging are presented.
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Study details
- Evidence strengthLow
How this study scored 38/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 21 of the 56 points we could judge it on, which is 38 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (American journal of nuclear medicine and molecular imaging) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2014 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 24795838) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 21 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 21 of the 56 points we could judge it on is 38 out of 100. |
| Total | 38 / 100 | — |
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Built from the record alzhub holds for this paper, not looked up. This record has no DOI, so the citation leaves it out. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
Morbelli, S., & Nobili, F. (2014). Cognitive reserve and clinical expression of Alzheimer's disease: evidence and implications for brain PET imaging. American journal of nuclear medicine and molecular imaging.
Vancouver
Morbelli S, Nobili F. Cognitive reserve and clinical expression of Alzheimer's disease: evidence and implications for brain PET imaging. American journal of nuclear medicine and molecular imaging. 2014. PMID: 24795838.
BibTeX
@article{morbelli2014-24795838,
author = {Morbelli, Silvia and Nobili, Flavio},
title = {{Cognitive reserve and clinical expression of Alzheimer's disease: evidence and implications for brain PET imaging}},
journal = {American journal of nuclear medicine and molecular imaging},
year = {2014},
pmid = {24795838}
}