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Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease
Rudolph E. Tanzi, Andrea I. McClatchey, Edward D. Lamperti, Lydia Villa‐Komaroff, James F. Gusella, Rachael L. Neve. Nature, 1988-02-01
Topic: Amyloid, tau and blood-test diagnosis
We do not hold a plain-English summary of this study yet. Use the links to the original below for its abstract and findings.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Tanzi, R. E., McClatchey, A. I., Lamperti, E. D., Villa‐Komaroff, L., Gusella, J. F., & Neve, R. L. (1988). Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease. Nature. https://doi.org/10.1038/331528a0
Vancouver
Tanzi RE, McClatchey AI, Lamperti ED, Villa‐Komaroff L, Gusella JF, Neve RL. Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease. Nature. 1988. doi:10.1038/331528a0. PMID: 2893290.
BibTeX
@article{tanzi1988-2893290,
author = {Tanzi, Rudolph E. and McClatchey, Andrea I. and Lamperti, Edward D. and Villa‐Komaroff, Lydia and Gusella, James F. and Neve, Rachael L.},
title = {{Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease}},
journal = {Nature},
year = {1988},
doi = {10.1038/331528a0},
pmid = {2893290},
url = {https://doi.org/10.1038/331528a0}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Why it matters
Reports a protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease.
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How this study scored 57/100
Published in a top-tier journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on strength of evidence, so that was left out: it earned 54 of the 95 points we could judge it on, which is 57 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 10 / 10 | Tier 1 — top-tier general journal (Nature) |
| Journal's citation record | 4 / 4 | Nature: journal h-index 1,841 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | — / 5 | No evidence rating recorded — left out of this score |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 1988 — older than 20 years, still counted |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 7 / 7 | Cited 1,097 times (OpenAlex, 2026-10-10) |
| Citations per year | 4 / 5 | 27.4 citations a year over 40 year(s) since 1988 |
| Impact for its field and year | 6 / 6 | Cited 97.5× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 1 / 4 | Cited 11 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Rachael L. Neve: h-index 124 (OpenAlex, whole career) |
| Institution's track record | 3 / 3 | Harvard University: institution h-index 3,235 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 4 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 2893290) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 54 / 95 | Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 54 of the 95 points we could judge it on is 57 out of 100. |
| Total | 57 / 100 | — |
What each of these 20 components measures, and what this score is not →
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