This page is alzhub.org's plain-English summary of a published study, not the paper itself. It is generated from the record we hold for this study, sourced and linked below — check the original for the full text and methods.

41/100

✓ Peer-reviewed alzhub usefulness score 41 out of 100. Tau biomarkers

Topic: Brain proteins, microglia and lab models

We estimated the overall concentration (mean standardized values) and principal components (PCs) of the proteomics and lipidomics data independently. Results Mean standardized intensities and the PC1 (explaining 40% and 60% of the CSF lipidomics and proteomics variance, respectively) were highly intercorrelated (Figure 1). Despite independent from disease groups and progression, these metrics were strongly associated with CSF p ‐tau181 and Aβ42 levels (Figure 2). GWAs revealed that GMNC , previously associated with CSF p ‐tau levels and lateral ventricular volume, and linked to multicilliated cell differentiation in the choroid plexus, was associated ( p <5·10 ‐08 ) with these metrics in both experiments. Known alleles increasing ventricular volume were negatively associated with the mean intensity and PC1, downregulating a substantial portion of the proteome (Figure 3). Interestingly, we observed a large overlap in both the down‐ and upregulated proteomic signature of these variants. Enrichment analysis revealed that proteins diluted by ventricular volume‐increasing alleles were related to neuronal function, while increased proteins were associated with immune functions, pinpointing CSF production/clearance rates as likely contributors to this phenomenon.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

García‐González, P., Puerta, R., Dehairs, J., de Rojas, I., Montrreal, L., Marquié, M., et al. (2025). Integrative multi‐omics analysis reveals physiological and genetic drivers of CSF biomarker variability: implications in neurodegeneration studies. Alzheimer s & Dementia. https://doi.org/10.1002/alz70856_099623

Vancouver

García‐González P, Puerta R, Dehairs J, de Rojas I, Montrreal L, Marquié M, et al. Integrative multi‐omics analysis reveals physiological and genetic drivers of CSF biomarker variability: implications in neurodegeneration studies. Alzheimer s & Dementia. 2025. doi:10.1002/alz70856_099623. PMID: 41447255.

BibTeX

@article{garciagonzalez2025-41447255,
  author  = {García‐González, Pablo and Puerta, Raquel and Dehairs, Jonas and de Rojas, Itziar and Montrreal, Laura and Marquié, Marta and Rosende‐Roca, Maitée and Emon, Asif Imran and others},
  title   = {{Integrative multi‐omics analysis reveals physiological and genetic drivers of CSF biomarker variability: implications in neurodegeneration studies}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70856_099623},
  pmid    = {41447255},
  url     = {https://doi.org/10.1002/alz70856_099623}
}

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.

Key findings

We estimated the overall concentration (mean standardized values) and principal components (PCs) of the proteomics and lipidomics data independently.
Results Mean standardized intensities and the PC1 (explaining 40% and 60% of the CSF lipidomics and proteomics variance, respectively) were highly intercorrelated (Figure 1).
Despite independent from disease groups and progression, these metrics were strongly associated with CSF p ‐tau181 and Aβ42 levels (Figure 2).
GWAs revealed that GMNC , previously associated with CSF p ‐tau levels and lateral ventricular volume, and linked to multicilliated cell differentiation in the choroid plexus, was associated ( p <5·10 ‐08 ) with these metrics in both experiments.
Known alleles increasing ventricular volume were negatively associated with the mean intensity and PC1, downregulating a substantial portion of the proteome (Figure 3).

Why it matters

This multi-omics study found that overall cerebrospinal fluid protein and lipid concentrations were strongly associated with CSF p-tau181 and Aβ42 levels, and that a genetic variant in GMNC was linked to these metrics. The authors suggest CSF production and clearance rates may contribute to biomarker variability, which has implications for how neurodegeneration studies are interpreted, but no treatment, prevention or cure is reported.

New to this subject? Start with our plain-English guide: Blood tests & biomarkers →

Study details

Participants1,372
Evidence strengthModerate

How this study scored 41/100

Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it. We have no data on senior author's track record, so that was left out: it earned 39 of the 96 points we could judge it on, which is 41 out of 100.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Alzheimer s & Dementia)
Journal's citation record	2 / 4	Alzheimer s & Dementia: journal h-index 228 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	3 / 5	Rated “moderate” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2025 — within 3 year(s) of the newest study here
Sample size	3 / 4	1,372 participants
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	0 / 7	Cited 0 times (OpenAlex, 2026-10-10)
Citations per year	0 / 5	0.0 citations a year over 3 year(s) since 2025
Impact for its field and year	0 / 6	Cited 0.0× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	0 / 4	Cited 0 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	— / 4	OpenAlex's profile for last-listed author A. Ballano Ruiz holds only 9 work(s), too few to judge a track record — left out of this score
Institution's track record	1 / 3	KU Leuven: institution h-index 1,386 (OpenAlex)
Multi-centre collaboration	2 / 3	OpenAlex lists 6 institution(s) in 3 countries
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 41447255)
Free to read	2 / 2	Free to read
Points	39 / 96	Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 39 of the 96 points we could judge it on is 41 out of 100.
Total	41 / 100	—

What each of these 20 components measures, and what this score is not →

Read the original

Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).

Related studies in Tau biomarkers

Also tagged “biomarkers”

821 studies in the library carry the topic tag “biomarkers”; these are this study's neighbours in a fixed, alphabetical-by-hash tour of them, not the closest in content. All 821 tagged studies.

Similar studies

More on Tau biomarkers

See all studies in Tau biomarkers →