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Preanalytical stability of plasma/serum brain-derived tau
Gonzalez-Ortiz F, Dias A, Turton M, Magalhães R, Kac PR, Correia M, Harrison P, Zetterberg H et al.. Alzheimer's & dementia : the journal of the Alzheimer's Association, 2023-05-26
Topic: Brain proteins, microglia and lab models
Introduction We investigated the effects of matrix type and reagent batch changes on diagnostic performances and longitudinal trajectories of brain-derived tau (BD-tau). Methods We evaluated (i) Cohort 1: paired EDTA plasma and serum from Alzheimer biomarker-positive older adults versus controls (n = 26); and (ii) Cohort 2: n = 79 acute ischemic stroke patients with 265 longitudinal samples across four time points. Results In Cohort 1, plasma and serum BD-tau were strongly correlated (rho = 0.96, p 99%) and correlations with CSF total-tau (rho = 0.93-0.94, p Discussion BD-tau has equivalent diagnostic accuracies, but non-interchangeable absolute concentrations, in plasma versus serum.
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APA 7th
Gonzalez-Ortiz, F., Dias, A., Turton, M., Magalhães, R., Kac, P. R., Correia, M., et al. (2023). Preanalytical stability of plasma/serum brain-derived tau. Alzheimer's & dementia : the journal of the Alzheimer's Association. https://doi.org/10.1002/alz.13156
Vancouver
Gonzalez-Ortiz F, Dias A, Turton M, Magalhães R, Kac PR, Correia M, et al. Preanalytical stability of plasma/serum brain-derived tau. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2023. doi:10.1002/alz.13156. PMID: 37232524.
BibTeX
@article{gonzalezortiz2023-37232524,
author = {Gonzalez-Ortiz, F. and Dias, A. and Turton, M. and Magalhães, R. and Kac, P. R. and Correia, M. and Harrison, P. and Zetterberg, H. and others},
title = {{Preanalytical stability of plasma/serum brain-derived tau}},
journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
year = {2023},
doi = {10.1002/alz.13156},
pmid = {37232524},
url = {https://doi.org/10.1002/alz.13156}
}
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Key findings
- Methods We evaluated (i) Cohort 1: paired EDTA plasma and serum from Alzheimer biomarker-positive older adults versus controls (n = 26); and (ii) Cohort 2: n = 79 acute ischemic stroke patients with 265 longitudinal samples across four time points.
- Results In Cohort 1, plasma and serum BD-tau were strongly correlated (rho = 0.96, p 99%) and correlations with CSF total-tau (rho = 0.93-0.94, p Discussion BD-tau has equivalent diagnostic accuracies, but non-interchangeable absolute concentrations, in plasma versus serum.
- Furthermore, the analytical robustness is unaffected by batch-to-batch reagent variations.
- Highlights Brain-derived tau (BD-tau) is a novel blood-based biomarker that quantifies tau protein of CNS origin.
Why it matters
This laboratory study found that brain-derived tau measured in plasma and serum gives similar diagnostic accuracy but the absolute values are not interchangeable. It is a technical finding about how to handle blood samples for testing, with no direct implications for treating or preventing Alzheimer's.
New to this subject? Start with our plain-English guide: Blood tests & biomarkers →
Study details
- Study designlongitudinal study
- Participants26
- Evidence strengthModerate
How this study scored 60/100
Published in a leading specialty journal, and it is a longitudinal study following the same people over time. Scored zero for effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Alzheimer's & dementia : the journal of the Alzheimer's Association) |
| Journal's citation record | 2 / 4 | Alzheimer s & Dementia: journal h-index 228 (OpenAlex, 2026-10-29) |
| Study design | 7 / 12 | A longitudinal study following the same people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2023 — within 6 year(s) of the newest study here |
| Sample size | 1 / 4 | 26 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 3 / 7 | Cited 22 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 4.4 citations a year over 5 year(s) since 2023 |
| Impact for its field and year | 3 / 6 | Cited 3.2× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 3 other studies in this library |
| Still being cited | 2 / 4 | Cited 21 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Thomas K. Karikari: h-index 66 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | University College London: institution h-index 2,029 (OpenAlex) |
| Multi-centre collaboration | 3 / 3 | OpenAlex lists 11 institution(s) in 4 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 37232524) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 60 / 100 | — |
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