Polygenic Effect on Tau Pathology Progression in Alzheimer's Disease
Anna Rubinski, Simon Frerich, Rainer Malik, Nicolai Franzmeier, Alfredo Ramirez, Martin Dichgans, Michael Ewers, Alzheimer's Disease Neuroimaging Initiative (ADNI). Annals of neurology, 2023-01-04
Topic: Plasma and spinal-fluid biomarkers
We found that a higher PGS was associated with higher rates of tau-PET accumulation, in particular at elevated amyloid-PET levels. The tau-PET increases mediated the association between PGS and faster cognitive decline. Risk enrichment through high PGS afforded sample size savings by 34%. Our results demonstrate that the PGS predicts faster tau progression and thus cognitive decline, showing utility to enhance statistical power in clinical trials. ANN NEUROL 2023;93:819-829.
Key findings
- We found that a higher PGS was associated with higher rates of tau-PET accumulation, in particular at elevated amyloid-PET levels.
- The tau-PET increases mediated the association between PGS and faster cognitive decline.
- Risk enrichment through high PGS afforded sample size savings by 34%.
- Our results demonstrate that the PGS predicts faster tau progression and thus cognitive decline, showing utility to enhance statistical power in clinical trials.
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Study details
- Study designlongitudinal study
- Participants85
- Evidence strengthModerate
How this study scored 68/100
Published in a leading specialty journal, and it is a longitudinal study following the same people over time. Scored zero for effect reported and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 38 of the 56 points we could judge it on, which is 68 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Annals of neurology) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 7 / 12 | A longitudinal study following the same people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2023 — within 6 year(s) of the newest study here |
| Sample size | 1 / 4 | 85 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 36571564) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 38 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 38 of the 56 points we could judge it on is 68 out of 100. |
| Total | 68 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
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Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 7 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
APA 7th
Rubinski, A., Frerich, S., Malik, R., Franzmeier, N., Ramirez, A., Dichgans, M., et al. (2023). Polygenic Effect on Tau Pathology Progression in Alzheimer's Disease. Annals of neurology. https://doi.org/10.1002/ana.26588
Vancouver
Rubinski A, Frerich S, Malik R, Franzmeier N, Ramirez A, Dichgans M, et al. Polygenic Effect on Tau Pathology Progression in Alzheimer's Disease. Annals of neurology. 2023. doi:10.1002/ana.26588. PMID: 36571564.
BibTeX
@article{rubinski2023-36571564,
author = {Rubinski, Anna and Frerich, Simon and Malik, Rainer and Franzmeier, Nicolai and Ramirez, Alfredo and Dichgans, Martin and Ewers, Michael},
title = {{Polygenic Effect on Tau Pathology Progression in Alzheimer's Disease}},
journal = {Annals of neurology},
year = {2023},
doi = {10.1002/ana.26588},
pmid = {36571564},
url = {https://doi.org/10.1002/ana.26588}
}
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