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Perception of movement and shape in Alzheimer's disease
Rizzo M, Nawrot M.. Brain : a journal of neurology, 1998-12-01
Topic: Amyloid, tau and blood-test diagnosis
Alzheimer's disease is the most prevalent cause of abnormal cognitive decline in older adults and commonly affects visual function. Recent evidence suggests that Alzheimer's disease impairs the processing of visual motion, but these conclusions are based on conflicting results in the few cases studied, and the processing of complex motion images has not been investigated. In the present study of motion processing in Alzheimer's disease we assessed visual functions in 63 adults: 41 with mild to moderate Alzheimer's disease (mean age 72.3 years) and 22 without dementia (mean age 71.7 years). Processing of motion cues was tested with computer animation sequences known as random-dot cinematograms, which resemble the stimuli used to define motion processing deficits in primates with lesions of cortical area MT. Results showed that participants with Alzheimer's disease required significantly greater thresholds for perceiving shapes defined by motion cues compared with participants without dementia (P = 0.0005). There were no significant differences between the two groups (P < 0.05) in static visual acuity, static spatial contrast sensitivity and, surprisingly, dynamic visual acuity, which was normal, and motion direction discrimination, which was relatively spared. We conclude that mild to moderate Alzheimer's disease has significant effects on the perception of structure from motion with relative sparing of motion direction discrimination. We cannot exclude a contribution by retinal pathology, but retinal dysfunction alone cannot explain the pattern of defects we observed. The complex motion image processing deficit we identified is likely to have a cerebral basis and has the potential to affect navigation and the recognition of objects in relative motion, as encountered during walking and automobile driving.
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APA 7th
Rizzo, M., & Nawrot, M. (1998). Perception of movement and shape in Alzheimer's disease. Brain : a journal of neurology. https://doi.org/10.1093/brain/121.12.2259
Vancouver
Rizzo M, Nawrot M. Perception of movement and shape in Alzheimer's disease. Brain : a journal of neurology. 1998. doi:10.1093/brain/121.12.2259. PMID: 9874479.
BibTeX
@article{rizzo1998-9874479,
author = {Rizzo, M. and Nawrot, M.},
title = {{Perception of movement and shape in Alzheimer's disease}},
journal = {Brain : a journal of neurology},
year = {1998},
doi = {10.1093/brain/121.12.2259},
pmid = {9874479},
url = {https://doi.org/10.1093/brain/121.12.2259}
}
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Key findings
- Recent evidence suggests that Alzheimer's disease impairs the processing of visual motion, but these conclusions are based on conflicting results in the few cases studied, and the processing of complex motion images has not been investigated.
- Results showed that participants with Alzheimer's disease required significantly greater thresholds for perceiving shapes defined by motion cues compared with participants without dementia (P = 0.0005).
- There were no significant differences between the two groups (P < 0.05) in static visual acuity, static spatial contrast sensitivity and, surprisingly, dynamic visual acuity, which was normal, and motion direction discrimination, which was relatively spared.
- We conclude that mild to moderate Alzheimer's disease has significant effects on the perception of structure from motion with relative sparing of motion direction discrimination.
- We cannot exclude a contribution by retinal pathology, but retinal dysfunction alone cannot explain the pattern of defects we observed.
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Study details
- Participants63
- Evidence strengthLow
How this study scored 47/100
Published in a leading specialty journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multi-centre collaboration, so those were left out: it earned 27 of the 58 points we could judge it on, which is 47 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Brain : a journal of neurology) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 1998 — older than 20 years, still counted |
| Sample size | 1 / 4 | 63 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 9874479) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 27 / 58 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 27 of the 58 points we could judge it on is 47 out of 100. |
| Total | 47 / 100 | — |
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