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Ophthalmoplegia Plus
David A. Drachman. Archives of Neurology, 1968-06-01
Topic: Brain imaging, connectivity and assessment
CONSIDERABLE interest has been focused on the entity of progressive external ophthalmoplegia (PEO) since the report of Kiloh and Nevin in 1951.1These authors were primarily concerned with the pathogenesis of the ocular muscle weakness, concluding that it was virtually always the result of a myopathic process. They regarded PEO as a distinctive and relatively isolated disorder, although occasionally associated with mild myopathy elsewhere; they considered its association with other neurodegenerative findings to be "extremely rare," citing only the cases of Marburg2and of Walsh.3More recently, however, PEO has been linked with a variety of neurologic abnormalities in increasing numbers of reports. In addition to myopathic involvement of limb musculature, other neurologic symptoms including pharyngeal weakness, peripheral neuropathy, cerebellar ataxia, spasticity, deafness, optic atrophy, and dementia have been observed in conjunction with PEO. Other organ systems also involved have included the heart, endocrine glands, skin,
Key findings
- CONSIDERABLE interest has been focused on the entity of progressive external ophthalmoplegia (PEO) since the report of Kiloh and Nevin in 1951.1These authors were primarily concerned with the pathogenesis of the ocular muscle weakness, concluding that it was virtually always the result of a myopathic process.
- They regarded PEO as a distinctive and relatively isolated disorder, although occasionally associated with mild myopathy elsewhere; they considered its association with other neurodegenerative findings to be "extremely rare," citing only the cases of Marburg2and of Walsh.3More recently, however, PEO has been linked with a variety of neurologic abnormalities in increasing numbers of reports.
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Study details
- Evidence strengthLow
How this study scored 36/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multi-centre collaboration, so those were left out: it earned 21 of the 58 points we could judge it on, which is 36 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Archives of Neurology) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 1968 — older than 20 years, still counted |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 5652994) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 21 / 58 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 21 of the 58 points we could judge it on is 36 out of 100. |
| Total | 36 / 100 | — |
What each of these 20 components measures, and what this score is not →
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Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
Drachman, D. A. (1968). Ophthalmoplegia Plus. Archives of Neurology. https://doi.org/10.1001/archneur.1968.00470360076008
Vancouver
Drachman DA. Ophthalmoplegia Plus. Archives of Neurology. 1968. doi:10.1001/archneur.1968.00470360076008. PMID: 5652994.
BibTeX
@article{drachman1968-5652994,
author = {Drachman, David A.},
title = {{Ophthalmoplegia Plus}},
journal = {Archives of Neurology},
year = {1968},
doi = {10.1001/archneur.1968.00470360076008},
pmid = {5652994},
url = {https://doi.org/10.1001/archneur.1968.00470360076008}
}