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Model of the Impact of Pharmacological and Non-pharmacological Treatment of Alzheimer’s Disease
Yanliel Feliciano González, Nanelli Feliciano González. [in]genio revista de investigación y labor creativa, 2025-12-01
Topic: Amyloid, tau and blood-test diagnosis
El Alzheimer es un trastorno neurodegenerativo que afecta la cognición y memoria. Este estudio investiga los mecanismos de la EA, evaluando tratamientos farmacológicos y no-farmacológicos, mediante la simulación de ecuaciones diferenciales. Se estudiaron tratamientos como la galantamina, un inhibidor de acetilcolinesterasa, y el lecanemab, un anticuerpo que afecta el EA, así como tratamientos no farmacológicos, como la fisioterapia, durante la progresión del Alzheimer. La combinación de tratamientos mostró un efecto beneficioso, manteniendo el rendimiento cognitivo y una menor acumulación de biomarcadores en comparación con los tratamientos individualizados. Esta investigación sugiere que estrategias terapéuticas y modelos computacionales pueden ser herramientas para explorar intervenciones contra el Alzheimer.
Key findings
- El Alzheimer es un trastorno neurodegenerativo que afecta la cognición y memoria.
- Este estudio investiga los mecanismos de la EA, evaluando tratamientos farmacológicos y no-farmacológicos, mediante la simulación de ecuaciones diferenciales.
- Se estudiaron tratamientos como la galantamina, un inhibidor de acetilcolinesterasa, y el lecanemab, un anticuerpo que afecta el EA, así como tratamientos no farmacológicos, como la fisioterapia, durante la progresión del Alzheimer.
- La combinación de tratamientos mostró un efecto beneficioso, manteniendo el rendimiento cognitivo y una menor acumulación de biomarcadores en comparación con los tratamientos individualizados.
- Esta investigación sugiere que estrategias terapéuticas y modelos computacionales pueden ser herramientas para explorar intervenciones contra el Alzheimer.
Why it matters
This study used differential equation simulations to model galantamine, lecanemab, and non-pharmacological treatment such as physiotherapy during Alzheimer's progression. The simulated combination showed a beneficial effect on cognitive performance and biomarker accumulation, but these are computer model results, not findings from patients.
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Study details
- Evidence strengthLow
How this study scored 26/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on senior author's track record, so that was left out: it earned 25 of the 96 points we could judge it on, which is 26 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal ([in]genio revista de investigación y labor creativa) |
| Journal's citation record | 0 / 4 | [in]genio revista de investigación y labor creativa: journal h-index 1 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 0 / 7 | Cited 0 times (OpenAlex, 2026-10-10) |
| Citations per year | 0 / 5 | 0.0 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 0 / 6 | Cited 0.0× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 0 / 4 | Cited 0 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | — / 4 | OpenAlex's profile for last-listed author Nanelli Feliciano González holds only 1 work(s), too few to judge a track record — left out of this score |
| Institution's track record | 0 / 3 | University of Puerto Rico at Cayey: institution h-index 67 (OpenAlex) |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 1 / 2 | Not in PubMed, but has a DOI |
| Free to read | 2 / 2 | Free to read |
| Points | 25 / 96 | Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 25 of the 96 points we could judge it on is 26 out of 100. |
| Total | 26 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.54114/ingeniosv12i1.10262
- Original source →
- Free full text: [in]genio revista de investigación y labor creativa →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
González, Y. F., & González, N. F. (2025). Model of the Impact of Pharmacological and Non-pharmacological Treatment of Alzheimer’s Disease. [in]genio revista de investigación y labor creativa. https://doi.org/10.54114/ingeniosv12i1.10262
Vancouver
González YF, González NF. Model of the Impact of Pharmacological and Non-pharmacological Treatment of Alzheimer’s Disease. [in]genio revista de investigación y labor creativa. 2025. doi:10.54114/ingeniosv12i1.10262.
BibTeX
@article{gonzalez2025-f695fc6b,
author = {González, Yanliel Feliciano and González, Nanelli Feliciano},
title = {{Model of the Impact of Pharmacological and Non-pharmacological Treatment of Alzheimer’s Disease}},
journal = {[in]genio revista de investigación y labor creativa},
year = {2025},
doi = {10.54114/ingeniosv12i1.10262},
url = {https://doi.org/10.54114/ingeniosv12i1.10262}
}
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