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45/100

✓ Peer-reviewed alzhub usefulness score 45 out of 100. Brain scans and imaging

Topic: Amyloid, tau and blood-test diagnosis

The clusters of significant depression and compensation were further used as volumetric regions of interest (ROIs) in a brain interregional correlation analysis in each prodromal AD subgroup to explore metabolic connectivity. All analyses were performed by means of SPM8 (P Results Highly educated prodromal AD patients showed more severe hypometabolism than poorly educated prodromal AD patients in the left inferior and middle temporal gyri and the left middle occipital gyrus (ROI depression). Conclusion The present findings suggest that highly educated prodromal AD patients can cope better with the disease thanks to neural reserve but also to the recruitment of compensatory neural networks in which the right DLFC plays a key role.

Key findings

The clusters of significant depression and compensation were further used as volumetric regions of interest (ROIs) in a brain interregional correlation analysis in each prodromal AD subgroup to explore metabolic connectivity.
All analyses were performed by means of SPM8 (P Results Highly educated prodromal AD patients showed more severe hypometabolism than poorly educated prodromal AD patients in the left inferior and middle temporal gyri and the left middle occipital gyrus (ROI depression).
Conclusion The present findings suggest that highly educated prodromal AD patients can cope better with the disease thanks to neural reserve but also to the recruitment of compensatory neural networks in which the right DLFC plays a key role.

Why it matters

In this imaging study, highly educated patients with prodromal Alzheimer's disease showed more severe hypometabolism in certain left-sided brain regions than poorly educated patients, suggesting they cope better through neural reserve and compensatory networks involving the right dorsolateral frontal cortex. It is an observational imaging finding and does not show that any treatment, cure or prevention works.

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Study details

Evidence strengthLow

How this study scored 45/100

Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Journal of nuclear medicine : official publication, Society of Nuclear Medicine)
Journal's citation record	2 / 4	Journal of Nuclear Medicine: journal h-index 230 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	1 / 5	2013 — within 20 year(s) of the newest study here
Sample size	0 / 4	Participant count not stated — scores zero (not stated in the record — scored 0)
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	0 / 3	Not stated whether this was studied in people — scores zero (not stated in the record — scored 0)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	5 / 7	Cited 120 times (OpenAlex, 2026-10-10)
Citations per year	3 / 5	8.0 citations a year over 15 year(s) since 2013
Impact for its field and year	3 / 6	Cited 7.9× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	1 / 6	Cited by 2 other studies in this library
Still being cited	1 / 4	Cited 7 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	3 / 4	Last-listed author Flavio Mariano Nobili: h-index 84 (OpenAlex, whole career)
Institution's track record	3 / 3	Centre National de la Recherche Scientifique: institution h-index 2,511 (OpenAlex)
Multi-centre collaboration	3 / 3	OpenAlex lists 14 institution(s) in 6 countries
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 23591639)
Free to read	0 / 2	Behind a paywall — scores zero
Total	45 / 100	—

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Read the original

Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

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APA 7th

Morbelli, S., Perneczky, R., Drzezga, A., Frisoni, G. B., Caroli, A., van Berckel, B. N., et al. (2013). Metabolic networks underlying cognitive reserve in prodromal Alzheimer disease: a European Alzheimer disease consortium project. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. https://doi.org/10.2967/jnumed.112.113928

Vancouver

Morbelli S, Perneczky R, Drzezga A, Frisoni GB, Caroli A, van Berckel BN, et al. Metabolic networks underlying cognitive reserve in prodromal Alzheimer disease: a European Alzheimer disease consortium project. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2013. doi:10.2967/jnumed.112.113928. PMID: 23591639.

BibTeX

@article{morbelli2013-23591639,
  author  = {Morbelli, S. and Perneczky, R. and Drzezga, A. and Frisoni, G. B. and Caroli, A. and van Berckel, B. N. and Ossenkoppele, R. and others},
  title   = {{Metabolic networks underlying cognitive reserve in prodromal Alzheimer disease: a European Alzheimer disease consortium project}},
  journal = {Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  year    = {2013},
  doi     = {10.2967/jnumed.112.113928},
  pmid    = {23591639},
  url     = {https://doi.org/10.2967/jnumed.112.113928}
}

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