Home › Research › Brain scans and imaging
Measures of cortical microstructure are linked to amyloid pathology in Alzheimer's disease
Spotorno N, Strandberg O, Vis G, Stomrud E, Nilsson M, Hansson O.. Brain : a journal of neurology, 2023-04-01
Topic: Amyloid, tau and blood-test diagnosis
Mean squared displacement revealed widespread microstructural differences already between Aβ-negative/tau-negative and Aβ-positive/tau-negative participants with a spatial distribution that closely resembled the pattern of Aβ accumulation. Further, the same metric exhibited significantly stronger correlations with PET uptake than cortical thickness (P < 0.05). Further, impairments in executive functions were significantly more associated with mean squared displacement values extracted from a meta-region of interest encompassing regions accumulating Aβ early in the disease process, than with cortical thickness (P < 0.05). Similarly, impairments in memory functions were significantly more associated with mean squared displacement values extracted from a temporal meta-region of interest than with cortical thickness (P < 0.05).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Spotorno, N., Strandberg, O., Vis, G., Stomrud, E., Nilsson, M., & Hansson, O. (2023). Measures of cortical microstructure are linked to amyloid pathology in Alzheimer's disease. Brain : a journal of neurology. https://doi.org/10.1093/brain/awac343
Vancouver
Spotorno N, Strandberg O, Vis G, Stomrud E, Nilsson M, Hansson O. Measures of cortical microstructure are linked to amyloid pathology in Alzheimer's disease. Brain : a journal of neurology. 2023. doi:10.1093/brain/awac343. PMID: 36130332.
BibTeX
@article{spotorno2023-36130332,
author = {Spotorno, N. and Strandberg, O. and Vis, G. and Stomrud, E. and Nilsson, M. and Hansson, O.},
title = {{Measures of cortical microstructure are linked to amyloid pathology in Alzheimer's disease}},
journal = {Brain : a journal of neurology},
year = {2023},
doi = {10.1093/brain/awac343},
pmid = {36130332},
url = {https://doi.org/10.1093/brain/awac343}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Key findings
- Mean squared displacement revealed widespread microstructural differences already between Aβ-negative/tau-negative and Aβ-positive/tau-negative participants with a spatial distribution that closely resembled the pattern of Aβ accumulation.
- Further, the same metric exhibited significantly stronger correlations with PET uptake than cortical thickness (P < 0.05).
- Further, impairments in executive functions were significantly more associated with mean squared displacement values extracted from a meta-region of interest encompassing regions accumulating Aβ early in the disease process, than with cortical thickness (P < 0.05).
- Similarly, impairments in memory functions were significantly more associated with mean squared displacement values extracted from a temporal meta-region of interest than with cortical thickness (P < 0.05).
New to this subject? Start with our plain-English guide: Brain scans & tests →
Study details
- Participants292
- Evidence strengthModerate
How this study scored 59/100
Published in a leading specialty journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multi-centre collaboration, so those were left out: it earned 34 of the 58 points we could judge it on, which is 59 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Brain : a journal of neurology) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2023 — within 6 year(s) of the newest study here |
| Sample size | 2 / 4 | 292 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 36130332) |
| Free to read | 2 / 2 | Free to read |
| Points | 34 / 58 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 34 of the 58 points we could judge it on is 59 out of 100. |
| Total | 59 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
Free copy unknown: no free-copy check has an answer for this record yet. That does not mean it is paywalled.