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38/100

✓ Peer-reviewed alzhub usefulness score 38 out of 100. Risk genes beyond APOE

Topic: Amyloid, tau and blood-test diagnosis

Plain-language summary

Alzheimer?s disease (AD) is a neurodegenerative disorder with a strong genetic component. This research aims to identify the relationship between ABCA7 rs3764650, PSEN1 rs165932, and AD in the northeast Algerian population and investigate genetic risk factors contributing to disease susceptibility. A case-control study was performed with 98 patients and 156 controls. DNA was isolated from blood samples by salting out. Genotyping of ABCA7 and PSEN1 polymorphisms was conducted using PCR-RFLP. Significant associations were observed between ABCA7 rs3764650 and AD under dominant and additive models. Similarly, PSEN1 rs165932 was associated with a higher risk of AD under dominant, recessive, and additive models. The frequency of the ABCA7 G allele was significantly associated with PSEN1 T allele carriers (P=0.033), with no significant association observed in non-carriers. In contrast, the PSEN1 T allele frequency was significant in both ABCA7 G allele carriers (P=0.006) and non-carriers (P=0.001). Allelic frequencies for ABCA7 and PSEN1 were higher in late-onset cases (P=0.003; P< 0.001) and females (P=0.006; P< 0.001). This study highlights the association of the ABCA7 rs3764650 G and PSEN1 rs165932 T alleles with AD susceptibility, particularly in females and late-onset cases, suggesting their relevance as genetic markers of disease risk.

What this study adds

Evidence grade: Moderate

This is a case-control study of 98 participants. In a case-control study of 98 patients and 156 controls in northeast Algeria, the ABCA7 rs3764650 and PSEN1 rs165932 variants were associated with higher Alzheimer's disease risk, particularly in females and late-onset cases. These findings suggest these variants may serve as genetic markers of disease risk, but they do not demonstrate a treatment or cure.

Taken from this record’s own fields, not from reading the paper. The grade is assigned from the abstract’s wording; what that means.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Achou, R., Ayachi, O. S., Boukhenaf, Y., Laouar, R., Razika, G., Abderrahim, M., et al. (2025). Genetic association of ABCA7 and PSEN1 polymorphisms with Alzheimer’s disease in the northeast Algerian population: Exploring risk factors. Archives of Biological Sciences. https://doi.org/10.2298/abs250208005a

Vancouver

Achou R, Ayachi OS, Boukhenaf Y, Laouar R, Razika G, Abderrahim M, et al. Genetic association of ABCA7 and PSEN1 polymorphisms with Alzheimer’s disease in the northeast Algerian population: Exploring risk factors. Archives of Biological Sciences. 2025. doi:10.2298/abs250208005a.

BibTeX

@article{achou2025-0c99f57b,
  author  = {Achou, Rayene and Ayachi, Ouarda Sariyah and Boukhenaf, Yasmina and Laouar, Rania and Razika, Gharzouli and Abderrahim, M’zahem and Boulala, Houda and Abadi, Noureddine and others},
  title   = {{Genetic association of ABCA7 and PSEN1 polymorphisms with Alzheimer’s disease in the northeast Algerian population: Exploring risk factors}},
  journal = {Archives of Biological Sciences},
  year    = {2025},
  doi     = {10.2298/abs250208005a},
  url     = {https://doi.org/10.2298/abs250208005a}
}

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.

How to read this study

Design: this is a case-control study. People with the condition are compared with people without it, looking backward at past exposures. Recall of the past can be uneven between the groups, and the design shows association, not cause.
Size: the record lists 98 participants. Ask whether that is enough for the question, and who they were.
Effect: the record gives no effect size, so the summary above cannot say how large any difference was.

What the evidence grade means here

This page is graded moderate. alzhub.org assigns the grade automatically from keywords in the abstract, not from reading the paper. Moderate means the abstract mentions a cohort, case-control or longitudinal design. It can add at most 5 of the 100 points in the study score, and it is a label about design, not a verdict on whether the findings are true.

New to reading papers? Six questions to ask of any Alzheimer’s study · how we score.

Key findings

Significant associations were observed between ABCA7 rs3764650 and AD under dominant and additive models.
Similarly, PSEN1 rs165932 was associated with a higher risk of AD under dominant, recessive, and additive models.
The frequency of the ABCA7 G allele was significantly associated with PSEN1 T allele carriers (P=0.033), with no significant association observed in non-carriers.
In contrast, the PSEN1 T allele frequency was significant in both ABCA7 G allele carriers (P=0.006) and non-carriers (P=0.001).

Why it matters

In a case-control study of 98 patients and 156 controls in northeast Algeria, the ABCA7 rs3764650 and PSEN1 rs165932 variants were associated with higher Alzheimer's disease risk, particularly in females and late-onset cases. These findings suggest these variants may serve as genetic markers of disease risk, but they do not demonstrate a treatment or cure.

New to this subject? Start with our plain-English guide: Genetics →

Study details

Study designcase-control study
Participants98
Evidence strengthModerate

How this study scored 38/100

Published in a peer-reviewed journal, and it is a case-control study. Scored zero for effect reported and randomized / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Archives of Biological Sciences)
Journal's citation record	0 / 4	Archives of Biological Sciences: journal h-index 42 (OpenAlex, 2026-10-29)
Study design	6 / 12	A case-control study
Strength of evidence	3 / 5	Rated “moderate” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2025 — within 3 year(s) of the newest study here
Sample size	1 / 4	98 participants
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomized / blinded	0 / 2	No randomization or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	0 / 7	Cited 0 times (OpenAlex, 2026-10-10)
Citations per year	0 / 5	0.0 citations a year over 3 year(s) since 2025
Impact for its field and year	0 / 6	Cited 0.0× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	0 / 4	Cited 0 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	1 / 4	Last-listed author Dalila Satta: h-index 15 (OpenAlex, whole career)
Institution's track record	0 / 3	University Frères Mentouri Constantine 1: institution h-index 139 (OpenAlex)
Multicenter collaboration	0 / 3	OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete)
Indexed in PubMed	1 / 2	Not in PubMed, but has a DOI
Free to read	2 / 2	Free to read
Total	38 / 100	—

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Read the original

Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).

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