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Environment and Neurodegenerative Diseases: An Update on miRNA Role
Ferrante M, Conti GO.. MicroRNA (Shariqah, United Arab Emirates), 2017-12-01
Topic: Air pollution and environmental exposures
Introduction The importance of neurodegenerative diseases on the management of public health is growing and the real role of the environment and miRNA in their occurrence is still unclear. miRNA can significantly affect the regulatory network. The complex variety and gene-regulatory capacity of miRNAs are particularly valuable in the brain, being a very complex organ with a functional specialization of neurons highly adaptable to environmental stimuli. In particular, an miRNAs role is demonstrated in neurological diseases as an effect to toxic and mutagenic substances exposure by the environment. Objective The focus was on the three most important neurodegenerative diseases: Alzheimer, Parkinson and Amyotrophic lateral sclerosis. Materials and methods A brief critical review on scientific papers of the last ten years using PuBMED, Scopus, Web of Science and Cochrane databases was carried out. Results Several studies have shown that miRNAs may contribute to neurodegeneration process in response to environmental risks. The miRNAs are known to play a dynamic role in many biochemical pathways of mammalian's brain, including neuroplasticity, stress responses, cellular signaling, etc. miRNAs have a role in neurodegenerative phenotype of AD, PD and ALS. The environmental chemicals such as metals and pesticides and then behavior can cause miRNA alterations via increasing oxidative stress and/or triggering inflammatory responses. Conclusion A discussion with theoretical and possible future research directions is provided and it is clear that the need is not only of longitudinal population studies and of better knowledge of epigenetics markers but, especially, of environmental policy interventions based on the green economy.
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APA 7th
Ferrante, M., & Conti, G. O. (2017). Environment and Neurodegenerative Diseases: An Update on miRNA Role. MicroRNA (Shariqah, United Arab Emirates). https://doi.org/10.2174/2211536606666170811151503
Vancouver
Ferrante M, Conti GO. Environment and Neurodegenerative Diseases: An Update on miRNA Role. MicroRNA (Shariqah, United Arab Emirates). 2017. doi:10.2174/2211536606666170811151503. PMID: 28799488.
BibTeX
@article{ferrante2017-28799488,
author = {Ferrante, M. and Conti, G. O.},
title = {{Environment and Neurodegenerative Diseases: An Update on miRNA Role}},
journal = {MicroRNA (Shariqah, United Arab Emirates)},
year = {2017},
doi = {10.2174/2211536606666170811151503},
pmid = {28799488},
url = {https://doi.org/10.2174/2211536606666170811151503}
}
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Key findings
- Introduction The importance of neurodegenerative diseases on the management of public health is growing and the real role of the environment and miRNA in their occurrence is still unclear. miRNA can significantly affect the regulatory network.
- In particular, an miRNAs role is demonstrated in neurological diseases as an effect to toxic and mutagenic substances exposure by the environment.
- Results Several studies have shown that miRNAs may contribute to neurodegeneration process in response to environmental risks.
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Study details
- Study designlongitudinal study
- Evidence strengthModerate
How this study scored 53/100
Published in a peer-reviewed journal, and it is a longitudinal study following the same people over time. Scored zero for sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multi-centre collaboration, so those were left out: it earned 31 of the 58 points we could judge it on, which is 53 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (MicroRNA (Shariqah, United Arab Emirates)) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 7 / 12 | A longitudinal study following the same people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2017 — within 10 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 28799488) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 31 / 58 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 31 of the 58 points we could judge it on is 53 out of 100. |
| Total | 53 / 100 | — |
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