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Divergent disruptive effects of soluble recombinant tau assemblies on synaptic plasticity in vivo
Yang Y, Ondrejcak T, Hu NW, Klyubin I, Rowan MJ.. Molecular brain, 2025-04-18
Topic: Brain proteins, microglia and lab models
Compared with tau fibrils, more water-soluble assemblies of either recombinant or patient-derived tau have been reported to exert relatively potent rapid synaptotoxic effects, including inhibition of synaptic long-term potentiation (LTP) in the hippocampus. We conclude that oTau and SτAs provide useful means to explore ways of targeting different synaptotoxic soluble tau species in tauopathies.
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APA 7th
Yang, Y., Ondrejcak, T., Hu, N. W., Klyubin, I., & Rowan, M. J. (2025). Divergent disruptive effects of soluble recombinant tau assemblies on synaptic plasticity in vivo. Molecular brain. https://doi.org/10.1186/s13041-025-01208-8
Vancouver
Yang Y, Ondrejcak T, Hu NW, Klyubin I, Rowan MJ. Divergent disruptive effects of soluble recombinant tau assemblies on synaptic plasticity in vivo. Molecular brain. 2025. doi:10.1186/s13041-025-01208-8. PMID: 40251677.
BibTeX
@article{yang2025-40251677,
author = {Yang, Y. and Ondrejcak, T. and Hu, N. W. and Klyubin, I. and Rowan, M. J.},
title = {{Divergent disruptive effects of soluble recombinant tau assemblies on synaptic plasticity in vivo}},
journal = {Molecular brain},
year = {2025},
doi = {10.1186/s13041-025-01208-8},
pmid = {40251677},
url = {https://doi.org/10.1186/s13041-025-01208-8}
}
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Key findings
- Compared with tau fibrils, more water-soluble assemblies of either recombinant or patient-derived tau have been reported to exert relatively potent rapid synaptotoxic effects, including inhibition of synaptic long-term potentiation (LTP) in the hippocampus.
- We conclude that oTau and SτAs provide useful means to explore ways of targeting different synaptotoxic soluble tau species in tauopathies.
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Study details
- Evidence strengthLow
How this study scored 45/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multi-centre collaboration, so those were left out: it earned 26 of the 58 points we could judge it on, which is 45 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Molecular brain) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 40251677) |
| Free to read | 2 / 2 | Free to read |
| Points | 26 / 58 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 26 of the 58 points we could judge it on is 45 out of 100. |
| Total | 45 / 100 | — |
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