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Cyclooxygenase-2 (COX-2) in inflammatory and degenerative brain diseases
Minghetti L.. Journal of neuropathology and experimental neurology, 2004-09-01
Topic: Brain proteins, microglia and lab models
Cyclooxygenase (COX) catalyses the first committed step in the synthesis of prostanoids, a large family of arachidonic acid metabolites comprising prostaglandins, prostacyclin, and thromboxanes, and is a major target of non-steroidal anti-inflammatory drugs (NSAIDs). COX exists as constitutive and inducible isoforms. COX-2 is the inducible isoform, rapidly expressed in several cell types in response to growth factors, cytokines, and pro-inflammatory molecules.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Minghetti, L. (2004). Cyclooxygenase-2 (COX-2) in inflammatory and degenerative brain diseases. Journal of neuropathology and experimental neurology. https://doi.org/10.1093/jnen/63.9.901
Vancouver
Minghetti L. Cyclooxygenase-2 (COX-2) in inflammatory and degenerative brain diseases. Journal of neuropathology and experimental neurology. 2004. doi:10.1093/jnen/63.9.901. PMID: 15453089.
BibTeX
@article{minghetti2004-15453089,
author = {Minghetti, L.},
title = {{Cyclooxygenase-2 (COX-2) in inflammatory and degenerative brain diseases}},
journal = {Journal of neuropathology and experimental neurology},
year = {2004},
doi = {10.1093/jnen/63.9.901},
pmid = {15453089},
url = {https://doi.org/10.1093/jnen/63.9.901}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Key findings
- COX exists as constitutive and inducible isoforms.
- COX-2 is the inducible isoform, rapidly expressed in several cell types in response to growth factors, cytokines, and pro-inflammatory molecules.
- Since its discovery in the early 1990s, COX-2 has emerged as a major player in inflammatory reactions in peripheral tissues.
- By extension, COX-2 expression in brain has been associated with pro-inflammatory activities, thought to be instrumental in neurodegenerative processes of several acute and chronic diseases.
Why it matters
This review describes COX-2 as an inducible enzyme expressed in response to inflammatory signals and links its brain expression to neurodegenerative processes. It is a descriptive review and reports no treatment, cure or prevention for Alzheimer's disease.
Study details
- Evidence strengthLow
How this study scored 44/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of neuropathology and experimental neurology) |
| Journal's citation record | 2 / 4 | Journal of Neuropathology & Experimental Neurology: journal h-index 239 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2004 — older than 20 years, still counted |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 6 / 7 | Cited 781 times (OpenAlex, 2026-10-10) |
| Citations per year | 4 / 5 | 32.5 citations a year over 24 year(s) since 2004 |
| Impact for its field and year | 4 / 6 | Cited 18.0× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 1 / 6 | Cited by 2 other studies in this library |
| Still being cited | 3 / 4 | Cited 106 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Luisa Minghetti: h-index 60 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | Istituto Superiore di Sanità: institution h-index 523 (OpenAlex) |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 15453089) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 44 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1093/jnen/63.9.901
- PubMed: 15453089
- Original source →
- Free full text: Journal of Neuropathology & Experimental Neurology →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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