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Clinicopathologic Heterogeneity and Glial Activation Patterns in Alzheimer Disease
Kouri N, Frankenhauser I, Peng Z, Labuzan SA, Boon BDC, Moloney CM, Pottier C, Wickland DP et al.. JAMA neurology, 2024-06-01
Topic: Amyloid, tau and blood-test diagnosis
Importance Factors associated with clinical heterogeneity in Alzheimer disease (AD) lay along a continuum hypothesized to associate with tangle distribution and are relevant for understanding glial activation considerations in therapeutic advancement. Results Of the 2809 autopsied individuals in the FLAME cohort, 1361 neuropathologically diagnosed AD cases were evaluated. Although AD cases with a CLix score less than 10 had higher cortical tangle count, we found lower percentage of CD68-activated microglia/macrophage burden (median [IQR], 0.46% [0.32%-0.75%]) compared with cases with a CLix score of 10 to 30 (median [IQR], 0.75% [0.51%-0.98%]) and on par with a CLix score of 30 or greater (median [IQR], 0.40% [0.32%-0.57%]; P = .02).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Kouri, N., Frankenhauser, I., Peng, Z., Labuzan, S. A., Boon, B. D. C., Moloney, C. M., et al. (2024). Clinicopathologic Heterogeneity and Glial Activation Patterns in Alzheimer Disease. JAMA neurology. https://doi.org/10.1001/jamaneurol.2024.0784
Vancouver
Kouri N, Frankenhauser I, Peng Z, Labuzan SA, Boon BDC, Moloney CM, et al. Clinicopathologic Heterogeneity and Glial Activation Patterns in Alzheimer Disease. JAMA neurology. 2024. doi:10.1001/jamaneurol.2024.0784. PMID: 38619853.
BibTeX
@article{kouri2024-38619853,
author = {Kouri, N. and Frankenhauser, I. and Peng, Z. and Labuzan, S. A. and Boon, B. D. C. and Moloney, C. M. and Pottier, C. and Wickland, D. P. and others},
title = {{Clinicopathologic Heterogeneity and Glial Activation Patterns in Alzheimer Disease}},
journal = {JAMA neurology},
year = {2024},
doi = {10.1001/jamaneurol.2024.0784},
pmid = {38619853},
url = {https://doi.org/10.1001/jamaneurol.2024.0784}
}
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Key findings
- Importance Factors associated with clinical heterogeneity in Alzheimer disease (AD) lay along a continuum hypothesized to associate with tangle distribution and are relevant for understanding glial activation considerations in therapeutic advancement.
- Results Of the 2809 autopsied individuals in the FLAME cohort, 1361 neuropathologically diagnosed AD cases were evaluated.
- Although AD cases with a CLix score less than 10 had higher cortical tangle count, we found lower percentage of CD68-activated microglia/macrophage burden (median [IQR], 0.46% [0.32%-0.75%]) compared with cases with a CLix score of 10 to 30 (median [IQR], 0.75% [0.51%-0.98%]) and on par with a CLix score of 30 or greater (median [IQR], 0.40% [0.32%-0.57%]; P = .02).
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Study details
- Study designcross-sectional
- Participants60
- Effect size0.46%; 0.32%; 0.75%
- Evidence strengthModerate
How this study scored 69/100
Published in a leading specialty journal, and it is a snapshot of people at one point in time. Scored zero for randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multi-centre collaboration, so those were left out: it earned 40 of the 58 points we could judge it on, which is 69 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (JAMA neurology) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 4 / 12 | A snapshot of people at one point in time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2024 — within 3 year(s) of the newest study here |
| Sample size | 1 / 4 | 60 participants |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 38619853) |
| Free to read | 2 / 2 | Free to read |
| Points | 40 / 58 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 40 of the 58 points we could judge it on is 69 out of 100. |
| Total | 69 / 100 | — |
What each of these 20 components measures, and what this score is not →
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