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Altered Macular Microvasculature in Mild Cognitive Impairment and Alzheimer Disease
Jiang H, Wei Y, Shi Y, Wright CB, Sun X, Gregori G, Zheng F, Vanner EA et al.. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society, 2018-09-01
Topic: Amyloid, tau and blood-test diagnosis
Background The goal of the present study was to analyze the macular microvacular network in mild cognitive impirment (MCI) and Alzheimer disease (AD). Methods Twelve patients with AD and 19 patients with MCI were recruited together with 21 cognitively normal controls with a similar range of ages. Optical coherence tomography angiography was used to image the retinal microvascular network at the macular region, including retinal vascular network (RVN), superficial vascular plexus (SVP), and deep vascular plexus (DVP). Fractal analysis (box counting, Dbox) representing the microvascular density was performed in different annular zones and quadrantal sectors. The macular ganglion cell-inner plexiform layer (GC-IPL) thickness was measured using Zeiss OCT. The relationship between the retinal microvasculature and clinical manifestations was analyzed. Results Patients with AD had lower densities of RVN, SVP, and DVP in the annulus, from 0.6 to 2.5 mm in diameter (P < 0.05) in comparison with controls. Patients with MCI had lower density of DVP in the superior nasal quadrant (P < 0.05) than that of the controls. There were no significant differences of GC-IPL thickness among groups (P > 0.05). There was a trend of vascular density loss from control to MCI then AD (P < 0.05). Retinal microvascular density of DVP was correlated with GC-IPL thickness (P < 0.05) in patients with AD, but not in patients with MCI and controls. Conclusions Patients with AD had less density of retinal microvascular networks than controls. Our findings suggest the presence of retinal microvascular dysfunction in AD.
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APA 7th
Jiang, H., Wei, Y., Shi, Y., Wright, C. B., Sun, X., Gregori, G., et al. (2018). Altered Macular Microvasculature in Mild Cognitive Impairment and Alzheimer Disease. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society. https://doi.org/10.1097/wno.0000000000000580
Vancouver
Jiang H, Wei Y, Shi Y, Wright CB, Sun X, Gregori G, et al. Altered Macular Microvasculature in Mild Cognitive Impairment and Alzheimer Disease. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society. 2018. doi:10.1097/wno.0000000000000580. PMID: 29040211.
BibTeX
@article{jiang2018-29040211,
author = {Jiang, H. and Wei, Y. and Shi, Y. and Wright, C. B. and Sun, X. and Gregori, G. and Zheng, F. and Vanner, E. A. and others},
title = {{Altered Macular Microvasculature in Mild Cognitive Impairment and Alzheimer Disease}},
journal = {Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society},
year = {2018},
doi = {10.1097/wno.0000000000000580},
pmid = {29040211},
url = {https://doi.org/10.1097/wno.0000000000000580}
}
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Key findings
- Results Patients with AD had lower densities of RVN, SVP, and DVP in the annulus, from 0.6 to 2.5 mm in diameter (P < 0.05) in comparison with controls.
- There were no significant differences of GC-IPL thickness among groups (P > 0.05).
- Our findings suggest the presence of retinal microvascular dysfunction in AD.
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Study details
- Participants19
- Evidence strengthLow
How this study scored 45/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multi-centre collaboration, so those were left out: it earned 26 of the 58 points we could judge it on, which is 45 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2018 — within 10 year(s) of the newest study here |
| Sample size | 1 / 4 | 19 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 29040211) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 26 / 58 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 26 of the 58 points we could judge it on is 45 out of 100. |
| Total | 45 / 100 | — |
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