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[A semiquantitative study on Alzheimer neurofibrillary tangles demonstrated immunohistochemically with anti-tau antibodies, in the brains of non-demented and demented old people]
Kuzuhara S, Ihara Y, Toyokura Y, Shimada H.. No to shinkei = Brain and nerve, 1989-05-01
Topic: Amyloid, tau and blood-test diagnosis
Submitted for the study were 116 autopsy brains, from 65 non-demented people, 24 patients with dementia of Alzheimer type (DAT) and 27 patients with vascular dementia, aged between 50 s and 100 s. Formalin-fixed, paraffin-embedded coronal sections of the brains at the level of the lateral geniculate body were immunohistochemically stained with the avidin-biotin-peroxidase complex procedure, using the anti-bodies to tau protein purified from human brains (anti-tau) as the primary antibodies. Alzheimer neurofibrillary tangles (NFTs) which were specifically and selectively stained by anti-tau were semiquantitatively counted in the areas of the hippocampus, parahippocampal gyrus and lateral occipitotemporal gyrus. The results were as follows: 1) In non-demented subjects, NFTs in the hippocampus and parahippocampal gyrus were scanty in the 50 s: they increased markedly after 60 years until 90 as the patients' age increased; they tended to decrease over 90 years. In contrast, NFTs in the lateral occipitotemporal gyrus remained none or scanty, always less than 10/mm2 field, throughout the ages between 50 s and 100 s. 2) In DAT cases, NFTs in the hippocampus and parahippocampal gyrus were numerous in all cases at any ages. NFTs in the lateral occipitotemporal gyrus were also many, and always more than 10/mm2 in all cases except a few ones over 80 years of age. The numbers of NFTs of the three areas were significantly higher in DAT cases than in non-demented subjects. 3) In most cases of vascular dementia, the density and distribution pattern of NFTs were essentially similar to those of non-demented subjects.(ABSTRACT TRUNCATED AT 250 WORDS)
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APA 7th
Kuzuhara, S., Ihara, Y., Toyokura, Y., & Shimada, H. (1989). [A semiquantitative study on Alzheimer neurofibrillary tangles demonstrated immunohistochemically with anti-tau antibodies, in the brains of non-demented and demented old people]. No to shinkei = Brain and nerve.
Vancouver
Kuzuhara S, Ihara Y, Toyokura Y, Shimada H. [A semiquantitative study on Alzheimer neurofibrillary tangles demonstrated immunohistochemically with anti-tau antibodies, in the brains of non-demented and demented old people]. No to shinkei = Brain and nerve. 1989. PMID: 2508732.
BibTeX
@article{kuzuhara1989-2508732,
author = {Kuzuhara, S. and Ihara, Y. and Toyokura, Y. and Shimada, H.},
title = {{[A semiquantitative study on Alzheimer neurofibrillary tangles demonstrated immunohistochemically with anti-tau antibodies, in the brains of non-demented and demented old people]}},
journal = {No to shinkei = Brain and nerve},
year = {1989},
pmid = {2508732}
}
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Key findings
- The results were as follows: 1) In non-demented subjects, NFTs in the hippocampus and parahippocampal gyrus were scanty in the 50 s: they increased markedly after 60 years until 90 as the patients' age increased; they tended to decrease over 90 years.
- The numbers of NFTs of the three areas were significantly higher in DAT cases than in non-demented subjects. 3) In most cases of vascular dementia, the density and distribution pattern of NFTs were essentially similar to those of non-demented subjects.(ABSTRACT TRUNCATED AT 250 WORDS)
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Study details
- Participants24
- Evidence strengthLow
How this study scored 43/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multi-centre collaboration, so those were left out: it earned 25 of the 58 points we could judge it on, which is 43 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (No to shinkei = Brain and nerve) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 1989 — older than 20 years, still counted |
| Sample size | 1 / 4 | 24 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 2508732) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 25 / 58 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 25 of the 58 points we could judge it on is 43 out of 100. |
| Total | 43 / 100 | — |
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Also tagged “demented”
2 studies in the library carry the topic tag “demented”; these are this study's neighbours in a fixed, alphabetical-by-hash tour of them, not the closest in content. All 2 tagged studies.