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6-month neurological and psychiatric outcomes in 236 379 survivors of COVID-19: a retrospective cohort study using electronic health records
Taquet M, Geddes JR, Husain M, Luciano S, Harrison PJ.. The lancet. Psychiatry, 2021-04-06
Topic: Risk, prevention and care in population studies
As with incidences, HRs were higher in patients who had more severe COVID-19 (eg, those admitted to ITU compared with those who were not: 1·58, 1·50-1·67, for any diagnosis; 2·87, 2·45-3·35, for any first diagnosis). Results were robust to various sensitivity analyses and benchmarking against the four additional index health events. Complementary study designs, including prospective cohorts, are needed to corroborate and explain these findings.
Key findings
- As with incidences, HRs were higher in patients who had more severe COVID-19 (eg, those admitted to ITU compared with those who were not: 1·58, 1·50-1·67, for any diagnosis; 2·87, 2·45-3·35, for any first diagnosis).
- Results were robust to various sensitivity analyses and benchmarking against the four additional index health events.
- Complementary study designs, including prospective cohorts, are needed to corroborate and explain these findings.
Why it matters
This retrospective cohort study of 236,379 COVID-19 survivors found that neurological and psychiatric outcomes were more common in patients who had more severe COVID-19, with higher hazard ratios in those admitted to intensive care. The authors state that complementary study designs, including prospective cohorts, are needed to corroborate and explain these findings, and the study does not address treating, curing, or preventing Alzheimer's disease.
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Study details
- Study designcohort study
- Participants379
- Evidence strengthModerate
How this study scored 72/100
Published in a peer-reviewed journal, and it is a cohort study following people over time. Scored zero for effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (The lancet. Psychiatry) |
| Journal's citation record | 2 / 4 | The Lancet Psychiatry: journal h-index 216 (OpenAlex, 2026-10-29) |
| Study design | 7 / 12 | A cohort study following people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2021 — within 6 year(s) of the newest study here |
| Sample size | 2 / 4 | 379 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 7 / 7 | Cited 2,198 times (OpenAlex, 2026-10-10) |
| Citations per year | 5 / 5 | 314.0 citations a year over 7 year(s) since 2021 |
| Impact for its field and year | 6 / 6 | Cited 193.6× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 1 / 6 | Cited by 2 other studies in this library |
| Still being cited | 4 / 4 | Cited 667 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Paul J. Harrison: h-index 102 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | University of Oxford: institution h-index 2,205 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 4 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 33836148) |
| Free to read | 2 / 2 | Free to read |
| Total | 72 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1016/s2215-0366(21)00084-5
- PubMed: 33836148
- Original source →
- Free full text: The Lancet Psychiatry →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
Taquet, M., Geddes, JR., Husain, M., Luciano, S., & Harrison, P. J. (2021). 6-month neurological and psychiatric outcomes in 236 379 survivors of COVID-19: a retrospective cohort study using electronic health records. The lancet. Psychiatry. https://doi.org/10.1016/s2215-0366(21)00084-5
Vancouver
Taquet M, Geddes JR, Husain M, Luciano S, Harrison PJ. 6-month neurological and psychiatric outcomes in 236 379 survivors of COVID-19: a retrospective cohort study using electronic health records. The lancet. Psychiatry. 2021. doi:10.1016/s2215-0366(21)00084-5. PMID: 33836148.
BibTeX
@article{taquet2021-33836148,
author = {Taquet, M. and Geddes, JR. and Husain, M. and Luciano, S. and Harrison, P. J.},
title = {{6-month neurological and psychiatric outcomes in 236 379 survivors of COVID-19: a retrospective cohort study using electronic health records}},
journal = {The lancet. Psychiatry},
year = {2021},
doi = {10.1016/s2215-0366(21)00084-5},
pmid = {33836148},
url = {https://doi.org/10.1016/s2215-0366(21)00084-5}
}
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