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Research

30,580 Alzheimer's and dementia studies in plain English, each scored out of 100.

Find studies

Showing 17,026–17,050 of 17,283 studies scoring 30–49 out of 100 (page 682 of 692) · 30,580 in the whole library · How the 0–100 score works

Download bibliography of the first 500 of these studies, in this order: BibTeX (.bib) · RIS (.ris)

Browse by subject, author or institution

Each number is how many studies that link shows, with your other filters kept.

Subjects

Authors

Names as each record prints them; the same person can appear under two spellings.

Institutions

From OpenAlex; 16,054 studies have no institution on record and are not counted here.

A note on reading research. One study is rarely the final word.

We try to note the size of a study, whether it was in humans or animals, and how early-stage the finding is. If a summary here doesn't make that clear, treat it with extra caution and check the original source.

Deposition of aggregated cystatin C-amyloid-β complexes and reduced cathepsin B activity modulate cerebral amyloid angiopathy pathogenesis

✓ Peer-reviewed alzhub usefulness score 32 out of 100. Journal of Neuropathology & Experimental Neurology 2025-12-17

Cystatin C (CST3) colocalizes with amyloid-β (Aβ) around vessels in cerebral amyloid angiopathy (CAA). 4 key findings →

Evidence: low

Full summary, score breakdown and related studies → Original source Full text may need a subscription

TDP-43 proteinopathy: the complex biological and clinical findings in LATE-NC, LANS, and other mixed age-related major neurocognitive disorders

✓ Peer-reviewed alzhub usefulness score 32 out of 100. Current Opinion in Psychiatry 2025-07-15

Since the term limbic-predominant age-related TDP-43 encephalopathy (LATE) was coined in 2019, more than 200 articles addressing the subject were published. 1 key finding →

Evidence: low

Full summary, score breakdown and related studies → Original source Full text may need a subscription

Transactive response DNA-binding protein 43 (TDP-43) proteinopathy: the complex biological and clinical findings in limbic-predominant age-related TDP-43 encephalopathy (LATE) neuropathological changes, limbic-predominant amnestic neurodegenerative syndrome, and other mixed age-related major neurocognitive disorders

✓ Peer-reviewed alzhub usefulness score 32 out of 100. Current Opinion in Psychiatry 2025-07-16

As the term limbic-predominant age-related transactive response DNA-binding protein 43 (TDP-43) encephalopathy (LATE) was coined in 2019, more than 200 articles addressing the subject were published. 1 key finding →

Evidence: low

Full summary, score breakdown and related studies → Original source Full text may need a subscription

Neuroinflammation and progress in clinical trials for the treatment of Alzheimer’s disease and related dementias: An update

✓ Peer-reviewed alzhub usefulness score 32 out of 100. Innovative Medicines & Omics 2025-03-28

According to the latest report in 2024 by the World Health Organization, based on global data from 2021, Alzheimer’s disease (AD) and other forms of dementia rank seventh among the leading causes of death worldwide, with an estimated 1.8 million deaths. 5 key findings →

Evidence: low

Full summary, score breakdown and related studies → Original source Free full text

Acupuncture reduces neuroinflammation and apoptosis, regulates peripheral immunity, and modulates T-cell subset distribution in vascular dementia rats

✓ Peer-reviewed alzhub usefulness score 32 out of 100. Chinese Medicine 2025-11-25

Acupuncture ameliorated cognitive impairment in VD rats, reduced hippocampal neuronal damage and apoptosis, downregulated pro-apoptotic proteins (cleaved-caspase 3 and Bax), and upregulated anti-apoptotic Bcl-2. 4 key findings →

Evidence: low

Full summary, score breakdown and related studies → Original source Free full text

Role of prion protein in mediating the synaptotoxic effects of tau oligomers: Implications for Alzheimer’s disease and related tauopathies

✓ Peer-reviewed alzhub usefulness score 32 out of 100. Neural Regeneration Research 2025-08-13

We recently confirmed and extended these findings using recombinant TauOs generated from full-length human tau in the presence of arachidonic acid (Balducci et al., 2025; Figure 1). 5 key findings →

Evidence: low

Full summary, score breakdown and related studies → Original source Free full text

2′-Fucosyllactose mitigates cognitive deficits in Alzheimer models: targeting amyloid pathology, oxidative stress, and synaptic plasticity

✓ Peer-reviewed alzhub usefulness score 32 out of 100. Frontiers in Pharmacology 2025-08-21

2′-FL improved cognitive performance in 5xFAD mice, reduced Aβ plaque deposition and pro-inflammatory cytokine levels in vivo , and mitigated oxidative stress and synaptic dysfunction in cellular models. 4 key findings →

Evidence: low

Full summary, score breakdown and related studies → Original source Free full text

Pyk2 plays a critical role in synaptic dysfunction during the early stages of Alzheimer’s disease

✓ Peer-reviewed alzhub usefulness score 32 out of 100. Molecular Neurodegeneration Advances 2026-03-07

The locus of the gene PTK2B encoding the tyrosine kinase Pyk2 has been associated with the risk of late-onset Alzheimer’s disease, the predominant form of dementia. 3 key findings →

Evidence: low

Full summary, score breakdown and related studies → Original source Free full text

A Case of Late‐Onset Semantic Dementia With Right‐Predominant Temporal Lobe Atrophy due to Primary Tauopathy

✓ Peer-reviewed alzhub usefulness score 32 out of 100. Psychogeriatrics 2025-09-01

Semantic dementia (SD) is a type of dementia characterized by a loss of semantic memory, typically presenting with left-predominant temporal lobe atrophy and a frontotemporal lobar degeneration with TDP-43 (FTLD-TDP) type C pathology. 3 key findings →

Evidence: low

Full summary, score breakdown and related studies → Original source Free full text

Alismatis Rhizoma prevents AβO-induced neuronal cell death and synaptic loss in Alzheimer’s disease models

✓ Peer-reviewed alzhub usefulness score 32 out of 100. Frontiers in Pharmacology 2026-09-04

In AβO-injected mice, AR, particularly at 200 mg/kg, attenuated memory deficits, reduced hippocampal neuronal degeneration, preserved synaptic protein immunoreactivity and increased markers of hippocampal cell proliferation and immature neurons. 5 key findings →

Evidence: low

Full summary, score breakdown and related studies → Original source Free full text

Dysregulation of a novel autophagosome-mitochondria contact contributes to tauopathy-related neurodegeneration by disrupting autophagy

✓ Peer-reviewed alzhub usefulness score 32 out of 100. Autophagy 2026-06-19

Beyond their role in energy production, mitochondria also interact with other organelles through forming membrane contacts that serve as central hubs of cellular metabolism and signaling. 2 key findings →

Evidence: low

Full summary, score breakdown and related studies → Original source Free full text

Classification of tauopathies from human brain homogenates through salt-modulated tau amplification

✓ Peer-reviewed alzhub usefulness score 32 out of 100. Apollo (University of Cambridge) 2026-01-15

This method differentiated eight tauopathies, including Alzheimer's disease, Pick disease, progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), argyrophilic grain disease (AGD), frontotemporal dementia with parkinsonism associated with chromosome 17 with N279K mutation (FTDP-17 N279K), and globular glial tauopathies types II and III. 5 key findings →

Evidence: low

Full summary, score breakdown and related studies → Original source Free full text

Cell type- and tau lesion-specific accumulation of phospho-Ser65 ubiquitin in primary tauopathies

✓ Peer-reviewed alzhub usefulness score 32 out of 100. Acta Neuropathologica Communications 2026-09-04

Defective mitochondrial quality control is increasingly implicated in tau-mediated neurodegeneration, but how distinct tau lesions in different cell types interact with PINK1-PRKN-mediated mitophagy remains unclear. 4 key findings →

Evidence: low

Full summary, score breakdown and related studies → Original source Free full text

A review on recent advances in Alzheimer's disease: The role of synaptic plasticity

✓ Peer-reviewed alzhub usefulness score 32 out of 100. AIMS neuroscience 2025-01-01

Alzheimer's Disease (AD) remains a significant global health challenge, characterized by progressive neurodegeneration and a decline in cognitive abilities such as memory and learning. 4 key findings →

Evidence: low

Full summary, score breakdown and related studies → Original source Free full text

Integrating repetitive transcranial magnetic stimulation and Mediterranean diet for cognitive and anxiety improvement in early Alzheimer's disease: A case report and literature review

✓ Peer-reviewed alzhub usefulness score 32 out of 100. Journal of Alzheimer s Disease Reports 2025-01-01

A 52-year-old male with early-stage Alzheimer's disease and long-standing anxiety received 30 repetitive transcranial magnetic stimulation sessions over 8 months and 20-month Mediterranean diet intervention. 5 key findings →

Evidence: low

Full summary, score breakdown and related studies → Original source Free full text

The effects of computer-based cognitive training on attention and working memory in Thai older adults with mild cognitive impairment

✓ Peer-reviewed alzhub usefulness score 32 out of 100. Journal of Associated Medical Sciences 2025-04-12

The results showed that the experimental group had a statistically significant difference of attention (TMT-B) and working memory scores, while the control group had no statistically significant difference for both attention and working memory. 3 key findings →

Participants: 13 Evidence: low

Full summary, score breakdown and related studies → Original source Free full text

Lifestyle Interventions for Cognitive Decline and Dementia Prevention: A Network Meta-analysis (P9-13.014)

✓ Peer-reviewed alzhub usefulness score 32 out of 100. Neurology 2026-06-09

To compare and rank the relative and additive effects of lifestyle components including exercise, diet, cognitive training, vascular management, and digital delivery on cognitive outcomes and dementia prevention in older adults without dementia. 1 key finding →

Evidence: low

Full summary, score breakdown and related studies → Original source Full text may need a subscription

ICF Application and Assessment Tool Analysis for Dysphagia Evaluation in Patients with Dementia: A Scoping Review

✓ Peer-reviewed alzhub usefulness score 32 out of 100. Journal of the Korean Dysphagia Society 2025-12-30

Instrumental assessments (Videofluoroscopic Swallowing Study [VFSS], Fiberoptic Endoscopic Evaluation of Swallowing [FEES]) and the Water Swallow Test were most frequently used.ICF mapping revealed that 96.7% of tools focused on body functions, while only approximately 20% addressed participation and environmental factors. 2 key findings →

Evidence: low

Full summary, score breakdown and related studies → Original source Free full text

Describing the elements of an effective dementia palliative care service

✓ Peer-reviewed alzhub usefulness score 32 out of 100. BMC Palliative Care 2025-05-22

The logic model and summary results explain in detail how this dementia palliative care service undertook activities relating to person-centred care, carer support, end-of-life care, accessible care, timely care, and integrated care. 3 key findings →

Evidence: low

Full summary, score breakdown and related studies → Original source Free full text

Designing and delivering palliative and end of life care research with people living with HIV: reflections from a co-produced study

✓ Peer-reviewed alzhub usefulness score 32 out of 100. Research Involvement and Engagement 2025-09-30

This has meant that fewer people are dying as a direct result of HIV, and the life expectancy for people living with HIV is almost the same as the general population in many countries. 2 key findings →

Evidence: low

Full summary, score breakdown and related studies → Original source Free full text

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Where “Free full text” comes from

Free full text links and the Full text may need a subscription label come from Unpaywall, Europe PMC and OpenAlex records of free copies, checked 10 Oct 2026. A study with neither is unknown, not paywalled. Show only studies that are free to read

How the 0–100 score works — and why some entries are capped

This is alzhub's own score. It is not an official metric, not an impact factor, and no journal, publisher or ranking body endorses it. We built it so that a reader who is not a scientist can tell a landmark trial from a conference abstract without having to already know the difference. Every point comes from one of 20 components, all of them printed on the study itself, so you can disagree with our arithmetic rather than having to trust the total.

  • Journal tier up to 10 pts
  • Journal's citation record up to 4 pts
  • Study design up to 12 pts
  • Strength of evidence up to 5 pts
  • Peer-review validation up to 10 pts
  • How recent up to 5 pts
  • Sample size up to 4 pts
  • Effect reported up to 3 pts
  • Studied in people up to 3 pts
  • Randomised / blinded up to 2 pts
  • Times cited up to 7 pts
  • Citations per year up to 5 pts
  • Impact for its field and year up to 6 pts
  • Cited by studies here up to 6 pts
  • Still being cited up to 4 pts
  • Senior author's track record up to 4 pts
  • Institution's track record up to 3 pts
  • Multi-centre collaboration up to 3 pts
  • Indexed in PubMed up to 2 pts
  • Free to read up to 2 pts

Journals are placed in ordered tiers, never given a numeric impact factor — we could not verify current impact factors from a source we control, and an invented one would be worse than none. Tier 1 is the top-tier general journals (NEJM, The Lancet, JAMA, Nature, Science, Nature Medicine); tier 2 is the leading specialty journals; tier 3 is every other peer-reviewed journal. A separate part scores how much the journal's own papers are cited, which tells the tier-3 journals apart.

Two rules we don't bend. First, we never fill in a missing value: if a record does not state a sample size or a design, that component scores zero, and if we simply have no data for a part, such as a citation count, that part is left out and the study is scored on the parts we could check. The study card says which. Second, anything that is not a peer-reviewed article is capped at 16/100 and carries a warning chip — so a conference abstract or a company press release can never outrank a peer-reviewed paper, no matter how good it looks.

We rank a rigorous null result — a good trial showing that something does not work — above an early positive finding. Someone deciding whether to buy a supplement is served by that, and the rigour is already counted by the design and journal components.

The score is computed from the published data alone and is reproducible: the same file always yields the same numbers.

See the whole rubric drawn out → — four charts covering all 30,580 studies: how the scores are spread and where the cap bites, which of the 20 components the library is strong and weak on, which subjects rest on stronger evidence, and what kinds of study each subject is actually built from.

What this library is — and isn't

This is a large sample of the Alzheimer's literature, not an exhaustive index of it. It holds 30,580 records, built mostly from automated pulls of Europe PMC (64.7% of the library) and OpenAlex (16.6%), plus smaller pulls from PubMed, Crossref and medRxiv. If a study, a drug, or a finding isn't here, that is not evidence it doesn't exist in the literature — it may simply not have been pulled in yet.

1,037 records (3.4% of the library) are not peer-reviewed — 964 of those are preprints posted before any journal review, and the rest are conference abstracts, regulatory notices and reports. Every study card on this page states its status plainly, and the score above is capped for anything that isn't a peer-reviewed article.

See the full, machine-readable breakdown of this library's coverage →

Newest studies, as a dated timeline →    Atom feed    Where this research is being discussed: events