28,180 Alzheimer's and dementia studies in plain English, each scored out of 100.
The term neuroenhancement refers to improvement in the cognitive, emotional and motivational functions of healthy individuals through, inter alia, the use of drugs. 2 key findings →
Design: systematic review Evidence: high
Full summary, score breakdown and related studies → Original source
OF THE FIELD: Alzheimer's disease (AD) is the most frequent, age-related neurodegenerative disorder and is characterized by progressive deterioration of cognition and global functioning. 1 key finding →
Design: meta-analysis Evidence: high
Full summary, score breakdown and related studies → Original source
14 studies were identified that matched inclusion criteria. 5 key findings →
Design: systematic review Evidence: high
Full summary, score breakdown and related studies → Original source
In the South Korean study to prevent cognitive impairment and protect BRAIN health through lifestyle intervention in at-risk elderly people (SUPERBRAIN), we evaluated the impact of a 24-week facility-based multidomain intervention (FMI) and home-based MI (HMI) on white matter integrity. 3 key findings →
Design: longitudinal study Participants: 152 Evidence: moderate
Full summary, score breakdown and related studies → Original source
At baseline, DSI was significantly associated with increased dementia prevalence compared to normal sensory function (odds ratio [OR] 2.17, 95% confidence interval [CI] 1.17-4.02), but SSI was not (OR 1.27, 95% CI 0.66-2.41). 4 key findings →
Design: cohort study Evidence: moderate
Full summary, score breakdown and related studies → Original source
Over 68,904 person-years of follow-up, 1,349 participants developed dementia. 5 key findings →
Design: longitudinal study Participants: 1,349 Evidence: moderate
Full summary, score breakdown and related studies → Original source
Daily driving is a multi-faceted, real-world, behavioral measure of cognitive functioning requiring multiple cognitive domains working synergistically to complete this instrumental activity of daily living. 1 key finding →
Design: longitudinal study Participants: 186 Evidence: moderate
Full summary, score breakdown and related studies → Original source
Social participation may theoretically decrease risk for mild cognitive impairment (MCI). 2 key findings →
Design: cross-sectional Participants: 32,715 Evidence: low
Full summary, score breakdown and related studies → Original source
Higher chronic exposure to SO2 was associated with a faster decline in memory score, whereas chronic exposure to CO, NO2 , and PM10 were not associated with the rate of cognitive decline. 4 key findings →
Design: longitudinal study Participants: 269 Evidence: moderate
Full summary, score breakdown and related studies → Original source
RECENT FINDINGS: Based on available epidemiological studies, two meta-analyses published in 2013 have underlined a protective effect of a greater MeDi adherence on cognitive health, including a reduced risk of Alzheimer's disease and cognitive impairment. 2 key findings →
Design: meta-analysis Evidence: high
Full summary, score breakdown and related studies → Original source
Emerging evidence suggests a potential role of gut dysbiosis in neurodegenerative disorders and, in particular, Alzheimer's disease (AD) pathology and cognitive decline. 4 key findings →
Design: cross-sectional Participants: 49 Evidence: moderate
Full summary, score breakdown and related studies → Original source
There is clinical overlap between presentations of dementia due to limbic-predominant age-related TDP-43 encephalopathy (LATE) and Alzheimer's disease. 4 key findings →
Design: longitudinal study Participants: 78 Evidence: moderate
Full summary, score breakdown and related studies → Original source
There were 11.8 transitions to a nursing home per 100 person-years among older adults who resided in an assisted living facility with a dementia care program, compared with 20.5 transitions to a nursing home per 100 person-years among older adults who resided in an assisted living facility without a dementia care program. 4 key findings →
Design: cohort study Participants: 977 Evidence: moderate
Full summary, score breakdown and related studies → Original source
Included in the analysis were 48,330 participants across 46 ADRCs (mean [SD] age, 71.3 [10.5] years; 20,767 female [57%]; 4,138 Hispanic [8.6%]; 1,392 non-Hispanic Asian [2.9%]; 6,766 non-Hispanic Black [14%] individuals; and 676 individuals [1.4%] of other races. 4 key findings →
Design: cross-sectional Participants: 48,330 Evidence: low
Full summary, score breakdown and related studies → Original source
Social determinants of health, including neighborhood factors, play a key role in the health of diverse older adults. 3 key findings →
Design: longitudinal study Participants: 452 Evidence: moderate
Full summary, score breakdown and related studies → Original source
The final sample comprised 2478 individuals, of which 59 (2.4%) were Asian, 63 (2.5%) were Black, and 2356 (95.1%) were White. 5 key findings →
Design: cross-sectional Participants: 2,478 Evidence: low
Full summary, score breakdown and related studies → Original source
Two models comprising behavior change and psychological impact fit well for the total sample and the two racial groups. 5 key findings →
Design: longitudinal study Participants: 334 Evidence: moderate
Full summary, score breakdown and related studies → Original source
Among the cohort of 7180 older adults (median age, 74 years [range, 65-102 years]; 4729 women [65.9%]), 1036 were African American or Black (14.4%), 21 were American Indian or Alaska Native (0.3%), 143 were Asian (2.0%), 332 were Hispanic (4.6%), and 5648 were non-Hispanic White (78.7%); the median educational level was 16.0 years (range, 1.0-29.0 years). 5 key findings →
Design: cohort study Evidence: moderate
Full summary, score breakdown and related studies → Original source
ϵ4 prevalence in Black (46%) and White participants (46%) was almost double that of Latino participants (24%). ϵ4 was associated with poorer baseline episodic memory only in White participants (p = .001), but had a moderately strong association with episodic memory change across all racial/ethnic groups (Blacks= -.061 SD/year, Latinos = -.055,Whites= -.055). ϵ4 association with semantic memory change was strongest in White participants (-.071), intermediate in Latino participants (-.041), and weakest in Black participants (-.022). 4 key findings →
Design: longitudinal study Participants: 297 Evidence: moderate
Full summary, score breakdown and related studies → Original source
The sample included 1 626 127 Medicare beneficiaries (mean [SD] age, 80.1 [8.0] years; 922 194 women [56.7%]) who received diagnoses of the 4 conditions in 2016. 5 key findings →
Design: cohort study Evidence: moderate
Full summary, score breakdown and related studies → Original source
DeFronzo Metrics Cited ByDiscovery of α-Glucosidase Inhibitors from Marine Microorganisms: Optimization of Culture Conditions and Medium CompositionBurdock fructooligosaccharide as an α-glucosidase inhibitor and its antidiabetic effect on high-fat diet and streptozotocin-induced diabetic miceThe antioxidant and antidiabetic potentials of polyphenolic-rich extracts of Cyperus rotundus (Linn.)From Pharmacogenetics to Gene Expression: Implications for Precision Medicine in DiabetesA narrative review of current trends in liraglutide: insights into the unmet needs in management of type 2 diabetes and obesitySynthesis, antidiabetic, antioxidant and anti-inflammatory activities of novel hydroxytriazenes based on sulpha drugsRNA-Seq Analysis of the Liver Transcriptome Reveals the Networks Regulating Treatment of Sitagliptin Phosphate plus Fuzhujiangtang Granule in the Zucker Diabetic Fatty RatsEverestmab, a novel long-acting GLP-1/anti GLP-1R nanobody fusion protein, exerts potent anti-diabetic effectsSPION‐Decorated Exosome Delivered BAY55‐9837 Targeting the Pancreas through Magnetism to Improve the Blood GLC ResponseA novel self-sufficient biocatalyst based on transaminase and pyridoxal 5′-phosphate covalent co-immobilization and its application in continuous biosynthesis of sitagliptinShared Pathological Mechanisms Between Diabetes Mellitus and Neurodegenerative DiseasesEffects of Lifestyle Modification and Anti-diabetic Medicine on Prediabetes Progress: A Systematic Review and Meta-AnalysisGlibenclamide Reduces Primary Human Monocyte Functions Against Tuberculosis Infection by Enhancing M2 PolarizationNaringin enhances reverse cholesterol transport in high fat/low streptozocin induced diabetic ratsA novel strategy to prepare the precursor peptide of liraglutideImpact of metformin on patients with advanced head and neck cancer undergoing concurrent chemoradiotherapyEffects of Different Doses of Metformin on Serum Fatty Acid Composition in Type 2 Diabetic RatsInsulin resistance and cognitive performance in type 2 diabetes — The Maastricht studyDesign and synthesis of novel thiazolidine-2,4-diones as hypoglycemic agentsMetformin in Amnestic Mild Cognitive Impairment: Results of a Pilot Randomized Placebo Controlled Clinical TrialMetformin and lifestyle modification in polycystic ovary syndrome: systematic review and meta-analysisGlibenclamide reduces pro-inflammatory cytokine production by neutrophils of diabetes patients in response to bacterial infectionNa + /H
Design: systematic review Evidence: high
Full summary, score breakdown and related studies → Original source
As shown in Table 2, attrition in LASA is associated with predictors and outcomes of interest to our research. 5 key findings →
Design: longitudinal study Participants: 3,805 Evidence: moderate
Full summary, score breakdown and related studies → Original source
Nocturnal hypoxemia was related to greater decline on the 3 MS . 5 key findings →
Design: longitudinal study Participants: 2,636 Evidence: moderate
Full summary, score breakdown and related studies → Original source
Plasma p-tau217 and cortical FTP-SUVR were correlated (r = 0.61, p < .001), especially in temporo-parietal and dorsolateral frontal cortices. 4 key findings →
Design: longitudinal study Participants: 85 Evidence: moderate
Full summary, score breakdown and related studies → Original source
The mechanisms by which the apolipoprotein E ε4 (APOEε4) allele influences the pathophysiological progression of Alzheimer's disease (AD) are poorly understood. 2 key findings →
Design: longitudinal study Participants: 94 Evidence: moderate
Full summary, score breakdown and related studies → Original source
Free full text links and the Full text may need a subscription label come from Unpaywall, Europe PMC and OpenAlex records of free copies, checked 10 Oct 2026. A study with neither is unknown, not paywalled. Show only studies that are free to read
This is alzhub's own score. It is not an official metric, not an impact factor, and no journal, publisher or ranking body endorses it. We built it so that a reader who is not a scientist can tell a landmark trial from a conference abstract without having to already know the difference. Every point comes from one of 20 components, all of them printed on the study itself, so you can disagree with our arithmetic rather than having to trust the total.
Journals are placed in ordered tiers, never given a numeric impact factor — we could not verify current impact factors from a source we control, and an invented one would be worse than none. Tier 1 is the top-tier general journals (NEJM, The Lancet, JAMA, Nature, Science, Nature Medicine); tier 2 is the leading specialty journals; tier 3 is every other peer-reviewed journal. A separate part scores how much the journal's own papers are cited, which tells the tier-3 journals apart.
Two rules we don't bend. First, we never fill in a missing value: if a record does not state a sample size or a design, that component scores zero, and if we simply have no data for a part, such as a citation count, that part is left out and the study is scored on the parts we could check. The study card says which. Second, anything that is not a peer-reviewed article is capped at 16/100 and carries a warning chip — so a conference abstract or a company press release can never outrank a peer-reviewed paper, no matter how good it looks.
We rank a rigorous null result — a good trial showing that something does not work — above an early positive finding. Someone deciding whether to buy a supplement is served by that, and the rigour is already counted by the design and journal components.
The score is computed from the published data alone and is reproducible: the same file always yields the same numbers.
See the whole rubric drawn out → — four charts covering all 28,180 studies: how the scores are spread and where the cap bites, which of the 20 components the library is strong and weak on, which subjects rest on stronger evidence, and what kinds of study each subject is actually built from.
This is a large sample of the Alzheimer's literature, not an exhaustive index of it. It holds 28,180 records, built mostly from automated pulls of Europe PMC (61.7% of the library) and OpenAlex (18.1%), plus smaller pulls from PubMed, Crossref and medRxiv. If a study, a drug, or a finding isn't here, that is not evidence it doesn't exist in the literature — it may simply not have been pulled in yet.
1,034 records (3.7% of the library) are not peer-reviewed — 962 of those are preprints posted before any journal review, and the rest are conference abstracts, regulatory notices and reports. Every study card on this page states its status plainly, and the score above is capped for anything that isn't a peer-reviewed article.
See the full, machine-readable breakdown of this library's coverage →