28,180 Alzheimer's and dementia studies in plain English, each scored out of 100.
Alzheimer's disease (AD) prevalence has increased in the last century which can be attributed to increased lifespan, but environment is also important. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Over 35% of the adult US population is obese. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Due to increasing lifespan and aging populations globally there has been a steep rise in late-life dementia, which is now the second most common cause of death in high-income countries. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Diabetes mellitus (DM) and Alzheimer's disease (AD) are two major health concerns that have seen a rising prevalence worldwide. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Cognition is a mental process that provides the ability to think, know, and learn. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
ObjectiveOlder individuals face a higher likelihood of developing dementia. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Some of these were the same already detected in a population without intellectual disabilities (education, occupation, physical activity, leisure, community and social activities); others were found to be specifically relevant for this population: type of schooling, parental educational level, environmental stimulation and living place. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
In a world with an ageing population, dementia has become an urgent threat to global health and wellbeing. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Social connectedness is important for maintaining cognitive function and cognitive health in older age. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
There were nine inclusion/exclusion criteria that were used in more than half of the late life depression AETs: minimum severity on a symptom severity scale (100.0%), significant suicidal ideation (77.8%), psychotic features during the current episode of depression or history of a psychotic disorder (94.4%), history of bipolar disorder (77.8%), diagnosis of alcohol or drug abuse or dependence (83.3%), presence of a comorbid nondepressive, nonsubstance use Axis I disorder (55.6%), episode duration too short (66.7%), and an insufficient score on a cognitive screen (88.3%) or the presence of a cognitive disorder (55.6%). 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
We respond to the commentary by Ballenger et al. While appreciating "our provocative article", they called for "a more rigorous historical approach…". 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Ambient fine particulate matter (PM2.5) is a key environmental risk factor closely associated with Alzheimer's disease (AD), although its specific molecular mechanisms remain incompletely elucidated. 4 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
The aggregation and prion-like propagation of tau are the hallmarks of Alzheimer's disease (AD) and other tauopathies. 4 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
The odds ratio (OR) for Alzheimer's disease was 0.996 with a p-value of 0.443 using the inverse variance weighted algorithm, and the OR associated with the outcome variable of delirium was 0.393 with a p-value of 0.343. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Air pollution is a critical global issue with extensive implications beyond respiratory health, significantly affecting neurological and psychiatric disorders. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
This paper delves into the increasingly recognized yet complex relationship between air pollution and Neurological Diseases. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Here we show that two different PMs derived from exhausts of cars running on EN590 diesel or compressed natural gas (CNG) alter the function of human microglia-like cells in vitro. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Fine particulate matter (PM2.5), a major component of air pollution, poses significant global health risks. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Polycyclic aromatic hydrocarbons (PAHs), which are widely present in incompletely combusted air particulate matter <2.5 μm (PM2.5), tobacco and other organic materials, can enter the human body through various routes and are a class of environmental pollutants with neurotoxic effects. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Exposures to fine particulate matter PM2.5 and ozone O3 are associated with Alzheimer's disease (AD) risk. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Respiratory viruses have a significant impact on health, as highlighted by the COVID-19 pandemic. 4 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Alzheimer's disease and related dementias are a leading cause of morbidity in our aging populations. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Environmental pollution exposures, including air, soil, water, light, and noise pollution, are critical issues that may implicate adverse mental health outcomes. 4 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Our MR analysis identified a notable association between genetically predicted PM2.5 (PM with a diameter of 2.5 μm or less) exposure and an elevated risk of AD (odds ratio, 2.160; 95% confidence interval, 1.481 to 3.149; p < 0.001). 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Fifteen cases were identified (14 men). All had clear histories of dream enactment behavior, and 10 had RBD confirmed by polysomnography. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Free full text links and the Full text may need a subscription label come from Unpaywall, Europe PMC and OpenAlex records of free copies, checked 10 Oct 2026. A study with neither is unknown, not paywalled. Show only studies that are free to read
This is alzhub's own score. It is not an official metric, not an impact factor, and no journal, publisher or ranking body endorses it. We built it so that a reader who is not a scientist can tell a landmark trial from a conference abstract without having to already know the difference. Every point comes from one of 20 components, all of them printed on the study itself, so you can disagree with our arithmetic rather than having to trust the total.
Journals are placed in ordered tiers, never given a numeric impact factor — we could not verify current impact factors from a source we control, and an invented one would be worse than none. Tier 1 is the top-tier general journals (NEJM, The Lancet, JAMA, Nature, Science, Nature Medicine); tier 2 is the leading specialty journals; tier 3 is every other peer-reviewed journal. A separate part scores how much the journal's own papers are cited, which tells the tier-3 journals apart.
Two rules we don't bend. First, we never fill in a missing value: if a record does not state a sample size or a design, that component scores zero, and if we simply have no data for a part, such as a citation count, that part is left out and the study is scored on the parts we could check. The study card says which. Second, anything that is not a peer-reviewed article is capped at 16/100 and carries a warning chip — so a conference abstract or a company press release can never outrank a peer-reviewed paper, no matter how good it looks.
We rank a rigorous null result — a good trial showing that something does not work — above an early positive finding. Someone deciding whether to buy a supplement is served by that, and the rigour is already counted by the design and journal components.
The score is computed from the published data alone and is reproducible: the same file always yields the same numbers.
See the whole rubric drawn out → — four charts covering all 28,180 studies: how the scores are spread and where the cap bites, which of the 20 components the library is strong and weak on, which subjects rest on stronger evidence, and what kinds of study each subject is actually built from.
This is a large sample of the Alzheimer's literature, not an exhaustive index of it. It holds 28,180 records, built mostly from automated pulls of Europe PMC (61.7% of the library) and OpenAlex (18.1%), plus smaller pulls from PubMed, Crossref and medRxiv. If a study, a drug, or a finding isn't here, that is not evidence it doesn't exist in the literature — it may simply not have been pulled in yet.
1,034 records (3.7% of the library) are not peer-reviewed — 962 of those are preprints posted before any journal review, and the rest are conference abstracts, regulatory notices and reports. Every study card on this page states its status plainly, and the score above is capped for anything that isn't a peer-reviewed article.
See the full, machine-readable breakdown of this library's coverage →