27,380 Alzheimer's and dementia studies in plain English, each scored out of 100.
Model scores two standard deviations below the mean had 4 months increased survival (two standard deviations below had 3 months decreased survival). 5 key findings →
Participants: 802 Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
Dementia, particularly Alzheimer's disease (AD), presents a growing global health challenge characterized by cognitive decline, behavioral changes, and loss of independence. 1 key finding →
Participants: 2,878 Evidence: moderate
Full summary, score breakdown and related studies → Original source Free full text
The progressive nature of dementia necessitates early detection strategies capable of identifying preclinical cognitive decline. 1 key finding →
Design: longitudinal study Evidence: moderate
Full summary, score breakdown and related studies → Original source Free full text
Dementia research often suffers from methodological pitfalls such as label-information and subject-information leakages. 2 key findings →
Design: longitudinal study Evidence: moderate
Full summary, score breakdown and related studies → Original source Free full text
This study developed machine learning models to predict Aβ positivity in Alzheimer’s disease by integrating early-phase 18 F-Florbetaben PET and clinical data to improve diagnostic accuracy. 2 key findings →
Participants: 176 Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
We identified 471 proteins with significant interaction effects between T2D and dementia risk. 5 key findings →
Participants: 2,920 Evidence: low
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Lower SES and education were the strongest predictors of increased behavioral risk. 5 key findings →
Design: cross-sectional Participants: 1,730 Evidence: low
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Isolated rapid eye movement sleep behavior disorder (iRBD) is a major prodromal marker of α-synucleinopathies, often preceding the clinical onset of Parkinson's disease, dementia with Lewy bodies, or multiple system atrophy. 3 key findings →
Participants: 31 Evidence: moderate
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The fall detection system detected 12 out of 15 real-life falls, having a sensitivity of 80.0%, with a false alarm rate of 0.049 alarms per usage hour with the implemented real-time system. 3 key findings →
Participants: 15,500 Evidence: low
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Accurate and early diagnosis of Alzheimer's disease (AD) plays important role for patient care and development of future treatment. 1 key finding →
Participants: 397 Evidence: low
Full summary, score breakdown and related studies → Original source
While computerised tomography (CT) may have been the first imaging tool to study human brain, it has not yet been implemented into clinical decision making process for diagnosis of Alzheimer's disease (AD). 2 key findings →
Participants: 285 Evidence: low
Full summary, score breakdown and related studies → Original source
Algorithms developed from health administrative data are sensitive and specific for identifying older adults with AD-RD. 1 key finding →
Participants: 3,404 Evidence: low
Full summary, score breakdown and related studies → Original source
In this study, mental disorders were associated with the onset of dementia in the population. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
The use of EHRs for AD-related research is promising, and AD-BERT shows superior predictive performance in modeling MCI-to-AD progression prediction. 1 key finding →
Participants: 3,657 Evidence: low
Full summary, score breakdown and related studies → Original source
This work suggests that academic and community factors beyond years of education have a marked impact on late-life cognition. 5 key findings →
Participants: 130 Evidence: moderate
Full summary, score breakdown and related studies → Original source
The restricted use of BDZRs may contribute to dementia prevention in the elderly. 4 key findings →
Design: case-control study Evidence: moderate
Full summary, score breakdown and related studies → Original source
Other than the early onset, this clinical phenotype is indistinguishable from sporadic AD except that affected individuals frequently complained of headache preceding and during the disease. 3 key findings →
Participants: 128 Evidence: low
Full summary, score breakdown and related studies → Original source
The findings support the idea that gait and balance assessment may augment the diagnostic evaluation of dementia. 1 key finding →
Design: cross-sectional Participants: 40 Evidence: low
Full summary, score breakdown and related studies → Original source
The final cohort comprised 52 patients, 30 of whom met basic PPA criteria. 5 key findings →
Participants: 52 Evidence: moderate
Full summary, score breakdown and related studies → Original source
Progressive non-fluent aphasia (PNFA) is a syndrome in which patients lose the ability to communicate fluently in the context of relative preservation of single word comprehension and non-linguistic cognitive abilities. 4 key findings →
Evidence: low
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This work is part of the multi-center Alzheimer's Disease Neuroimaging Initiative (ADNI), a large multi-site study of dementia, including patients having mild cognitive impairment (MCI), probable Alzheimer's disease (AD), as well as healthy elderly controls. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
We studied the clinical features, pathology, and molecular genetics of a family (Mo) with an autosomal dominant disinhibition, frontal lobe dementia, parkinsonism, and amyotrophy. 5 key findings →
Evidence: low
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Two patients with nonfluent progressive aphasia, who have been studied longitudinally, are contrasted with a group of 5 patients with fluent progressive aphasia or semantic dementia. 5 key findings →
Evidence: low
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Due to the COVID-19 pandemic, most memory clinics have had to suspend their activities. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
The increasing ageing global population is causing an upsurge in ailments related to old age, primarily dementia and Alzheimer's disease, frailty, Parkinson's, and cardiovascular disease, but also a general need for general eldercare as well as active and healthy ageing. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
Free full text links and the Full text may need a subscription label come from Unpaywall, Europe PMC and OpenAlex records of free copies, checked 10 Oct 2026. A study with neither is unknown, not paywalled. Show only studies that are free to read
This is alzhub's own score. It is not an official metric, not an impact factor, and no journal, publisher or ranking body endorses it. We built it so that a reader who is not a scientist can tell a landmark trial from a conference abstract without having to already know the difference. Every point comes from one of 20 components, all of them printed on the study itself, so you can disagree with our arithmetic rather than having to trust the total.
Journals are placed in ordered tiers, never given a numeric impact factor — we could not verify current impact factors from a source we control, and an invented one would be worse than none. Tier 1 is the top-tier general journals (NEJM, The Lancet, JAMA, Nature, Science, Nature Medicine); tier 2 is the leading specialty journals; tier 3 is every other peer-reviewed journal. A separate part scores how much the journal's own papers are cited, which tells the tier-3 journals apart.
Two rules we don't bend. First, we never fill in a missing value: if a record does not state a sample size or a design, that component scores zero, and if we simply have no data for a part, such as a citation count, that part is left out and the study is scored on the parts we could check. The study card says which. Second, anything that is not a peer-reviewed article is capped at 16/100 and carries a warning chip — so a conference abstract or a company press release can never outrank a peer-reviewed paper, no matter how good it looks.
We rank a rigorous null result — a good trial showing that something does not work — above an early positive finding. Someone deciding whether to buy a supplement is served by that, and the rigour is already counted by the design and journal components.
The score is computed from the published data alone and is reproducible: the same file always yields the same numbers.
See the whole rubric drawn out → — four charts covering all 27,380 studies: how the scores are spread and where the cap bites, which of the 20 components the library is strong and weak on, which subjects rest on stronger evidence, and what kinds of study each subject is actually built from.
This is a large sample of the Alzheimer's literature, not an exhaustive index of it. It holds 27,380 records, built mostly from automated pulls of Europe PMC (60.6% of the library) and OpenAlex (18.6%), plus smaller pulls from PubMed, Crossref and medRxiv. If a study, a drug, or a finding isn't here, that is not evidence it doesn't exist in the literature — it may simply not have been pulled in yet.
1,032 records (3.8% of the library) are not peer-reviewed — 962 of those are preprints posted before any journal review, and the rest are conference abstracts, regulatory notices and reports. Every study card on this page states its status plainly, and the score above is capped for anything that isn't a peer-reviewed article.
See the full, machine-readable breakdown of this library's coverage →