28,580 Alzheimer's and dementia studies in plain English, each scored out of 100.
Impaired odor identification, particularly in the anosmic range, is associated with increased mortality in older adults even after controlling for dementia and medical comorbidity. 3 key findings →
Evidence: moderate
Full summary, score breakdown and related studies → Original source
Overall, 156 (12.5%) women reported taking oestrogen after onset of menopause. 2 key findings →
Design: longitudinal study Participants: 1,124 Evidence: moderate
Full summary, score breakdown and related studies → Original source
Among Caucasian subjects from clinic- or autopsy-based studies, the risk of AD was significantly increased for people with genotypes epsilon2/epsilon4 (OR=2.6, 95% CI=1.6-4.0), epsilon3/epsilon4 (OR=3.2, 95% CI=2.8-3.8), and epsilon4/epsilon4 (OR=14.9, 95% CI= 10.8-20.6); whereas, the ORs were decreased for people with genotypes epsilon2/epsilon2 (OR=0.6, 95% CI=0.2-2.0) and epsilon2/epsilon3 (OR=0.6, 95% CI=0.5-0.8). 2 key findings →
Participants: 5,930 Evidence: low
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The association of depression with prevalent MCI and with progression from MCI to dementia, but not with incident MCI, suggests that depression accompanies cognitive impairment but does not precede it. 4 key findings →
Design: cohort study Participants: 2,160 Evidence: moderate
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Diabetes is related to a higher risk of amnestic MCI in a population with a high prevalence of this disorder. 5 key findings →
Design: cohort study Participants: 1,772 Evidence: moderate
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The data suggest that increased educational and occupational attainment may reduce the risk of incident AD, either by decreasing ease of clinical detection of AD or by imparting a reserve that delays the onset of clinical manifestations. 2 key findings →
Design: cross-sectional Participants: 593 Evidence: moderate
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Hypertension after age 65 years is not associated with AD and does not adversely affect memory, language, or general cognitive function. 5 key findings →
Design: longitudinal study Participants: 1,259 Evidence: moderate
Full summary, score breakdown and related studies → Original source
When proper normative values are used, only age and education, and not race or ethnicity, are associated with higher frequency of MCI. 4 key findings →
Design: cohort study Evidence: moderate
Full summary, score breakdown and related studies → Original source Free full text
APOE shows a heterogeneous effect on ADRD risk in our Hispanics/Latinos sample, the largest to date. 4 key findings →
Design: case-control Participants: 12,221 Evidence: moderate
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Immunization against amyloid-beta has been suggested as a possible preventive or therapeutic treatment for Alzheimer's disease. 1 key finding →
Design: longitudinal study Participants: 365 Evidence: moderate
Full summary, score breakdown and related studies → Original source
OHL was associated with greater risk of incident dementia in a multiethnic cohort. 4 key findings →
Design: cohort study Participants: 1,881 Evidence: moderate
Full summary, score breakdown and related studies → Original source
High homocysteine levels were not associated with AD and were not related to a decrease in memory scores over time. 4 key findings →
Design: longitudinal study Participants: 679 Evidence: moderate
Full summary, score breakdown and related studies → Original source
MTUS2 encodes a microtubule associated protein implicated in the development and function of the nervous system, making it a plausible candidate to investigate LOAD biology. 4 key findings →
Participants: 14,260 Evidence: moderate
Full summary, score breakdown and related studies → Original source
Hyperinsulinemia is associated with a higher risk of AD and decline in memory. 4 key findings →
Participants: 683 Evidence: moderate
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A history of hypertension is related to a higher risk of MCI. 5 key findings →
Design: cohort study Participants: 918 Evidence: moderate
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Impaired memory and language were useful predictors of transition to AD. 2 key findings →
Participants: 2,364 Evidence: low
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In the 852 subjects without dementia, depressed mood was more common in individuals with greater cognitive impairment. 3 key findings →
Design: longitudinal study Participants: 1,070 Evidence: moderate
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APOE genotyping does not provide sufficient sensitivity or specificity to be used alone as a diagnostic test for Alzheimer's disease, but when used in combination with clinical criteria, it improves the specificity of the diagnosis. 5 key findings →
Participants: 2,188 Evidence: low
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The TICS has high diagnostic validity for identification of dementia among ethnically diverse older adults, especially when supported by the DQ and prior visit data. 2 key findings →
Design: longitudinal study Participants: 256 Evidence: moderate
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Diabetes and current smoking were the strongest risk factors, but clusters including hypertension and heart disease also increased the risk of AD. 1 key finding →
Participants: 1,138 Evidence: low
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Higher adherence to the MeDi is associated with a trend for reduced risk of developing MCI and with reduced risk of MCI conversion to AD. 4 key findings →
Participants: 482 Evidence: moderate
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We hypothesized that telomere length might thus relate to increased risk for dementia and mortality. 2 key findings →
Design: case-control study Participants: 257 Evidence: moderate
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Consumption of up to three servings of wine daily is associated with a lower risk of AD in elderly individuals without the APOE epsilon-4 allele. 5 key findings →
Design: cohort study Participants: 260 Evidence: moderate
Full summary, score breakdown and related studies → Original source
The results of this preliminary case-control study suggest that estradiol levels may decline significantly in women in whom AD develops. 5 key findings →
Design: case-control study Participants: 50 Evidence: moderate
Full summary, score breakdown and related studies → Original source
Stroke is associated with AD among elderly individuals. 4 key findings →
Design: longitudinal study Evidence: moderate
Full summary, score breakdown and related studies → Original source Free full text
Free full text links and the Full text may need a subscription label come from Unpaywall, Europe PMC and OpenAlex records of free copies, checked 10 Oct 2026. A study with neither is unknown, not paywalled. Show only studies that are free to read
This is alzhub's own score. It is not an official metric, not an impact factor, and no journal, publisher or ranking body endorses it. We built it so that a reader who is not a scientist can tell a landmark trial from a conference abstract without having to already know the difference. Every point comes from one of 20 components, all of them printed on the study itself, so you can disagree with our arithmetic rather than having to trust the total.
Journals are placed in ordered tiers, never given a numeric impact factor — we could not verify current impact factors from a source we control, and an invented one would be worse than none. Tier 1 is the top-tier general journals (NEJM, The Lancet, JAMA, Nature, Science, Nature Medicine); tier 2 is the leading specialty journals; tier 3 is every other peer-reviewed journal. A separate part scores how much the journal's own papers are cited, which tells the tier-3 journals apart.
Two rules we don't bend. First, we never fill in a missing value: if a record does not state a sample size or a design, that component scores zero, and if we simply have no data for a part, such as a citation count, that part is left out and the study is scored on the parts we could check. The study card says which. Second, anything that is not a peer-reviewed article is capped at 16/100 and carries a warning chip — so a conference abstract or a company press release can never outrank a peer-reviewed paper, no matter how good it looks.
We rank a rigorous null result — a good trial showing that something does not work — above an early positive finding. Someone deciding whether to buy a supplement is served by that, and the rigour is already counted by the design and journal components.
The score is computed from the published data alone and is reproducible: the same file always yields the same numbers.
See the whole rubric drawn out → — four charts covering all 28,580 studies: how the scores are spread and where the cap bites, which of the 20 components the library is strong and weak on, which subjects rest on stronger evidence, and what kinds of study each subject is actually built from.
This is a large sample of the Alzheimer's literature, not an exhaustive index of it. It holds 28,580 records, built mostly from automated pulls of Europe PMC (62.2% of the library) and OpenAlex (17.8%), plus smaller pulls from PubMed, Crossref and medRxiv. If a study, a drug, or a finding isn't here, that is not evidence it doesn't exist in the literature — it may simply not have been pulled in yet.
1,034 records (3.6% of the library) are not peer-reviewed — 962 of those are preprints posted before any journal review, and the rest are conference abstracts, regulatory notices and reports. Every study card on this page states its status plainly, and the score above is capped for anything that isn't a peer-reviewed article.
See the full, machine-readable breakdown of this library's coverage →