A total of 45 reviews with 212 meta-analyses were synthesized. 5 key findings →
Design: meta-analysis Participants: 45 Evidence: high
Full summary, score breakdown and related studies → Original source
Research
28,180 Alzheimer's and dementia studies in plain English, each scored out of 100.
Forty-five studies involving over 730 000 participants were included. 5 key findings →
Design: systematic review Evidence: high
Full summary, score breakdown and related studies → Original source
PA was associated with lower incidence of all-cause dementia and Alzheimer's disease, even in longer follow-ups, supporting PA as a modifiable protective lifestyle factor, even after reducing the effects of reverse causation. 5 key findings →
Design: meta-analysis Participants: 257,983 Evidence: moderate
Full summary, score breakdown and related studies → Original source Free full text
A moderate to high intensity aerobic and strength exercise training programme does not slow cognitive impairment in people with mild to moderate dementia. 1 key finding →
Design: RCT Participants: 494 Evidence: null result
Full summary, score breakdown and related studies → Original source Free full text
Trial registration clinicaltrials.gov Identifier: NCT00056225. 1 key finding →
Participants: 340 Evidence: high
Full summary, score breakdown and related studies → Original source Free full text
Sleep disturbances and dementia are two common and significant health problems in older adults. 5 key findings →
Design: meta-analysis Participants: 246,786 Evidence: high
Full summary, score breakdown and related studies → Original source Full text may need a subscription
Among older adults without cognitive impairment or dementia, both an unfavorable lifestyle and high genetic risk were significantly associated with higher dementia risk. 5 key findings →
Design: cohort study Participants: 383 Evidence: moderate
Full summary, score breakdown and related studies → Original source Free full text
An intervention with MedDiets enhanced with either EVOO or nuts appears to improve cognition compared with a low-fat diet. 5 key findings →
Participants: 522 Evidence: high
Full summary, score breakdown and related studies → Original source Full text may need a subscription
Participants had a mean age of 73.4 years; 62.7% were women, and 34.9% were Hispanic or nonwhite. 5 key findings →
Design: randomized controlled trial Participants: 126 Evidence: high
Full summary, score breakdown and related studies → Original source Free full text
The mean rate of brain atrophy per year was 0.76% [95% CI, 0.63-0.90] in the active treatment group and 1.08% [0.94-1.22] in the placebo group (P = 0.001). 2 key findings →
Design: randomized controlled trial Participants: 271 Evidence: high
Full summary, score breakdown and related studies → Original source Free full text
This meta-analysis provides evidence that CCT improves cognitive function in older people with MCI. 2 key findings →
Design: systematic review Participants: 690 Evidence: high
Full summary, score breakdown and related studies → Original source
The possibilities of computer-based cognitive training (CCT) in postponing the onset of dementia are currently unclear, but promising. 4 key findings →
Participants: 631 Evidence: high
Full summary, score breakdown and related studies → Original source
Our findings suggest that higher adherence to the MIND diet was associated with better cognitive function and potentially slower cognitive decline in later life. 4 key findings →
Design: meta-analysis Participants: 4,066 Evidence: high
Full summary, score breakdown and related studies → Original source
The included studies (n=15) assessed change in cognition in response to a multidomain lifestyle intervention. 5 key findings →
Design: systematic review Participants: 15 Evidence: high
Full summary, score breakdown and related studies → Original source
This pilot study showed that functional tasks exercise using simulated functional tasks as a means of combined cognitive and exercise program is feasible and beneficial in improving the memory and functional status of older adults with mild cognitive impairment as well as reducing the care-related burdens of their caregivers. 2 key findings →
Design: randomized controlled trial Participants: 59 Evidence: high
Full summary, score breakdown and related studies → Original source
Dementia prevalence is a global public health concern. 2 key findings →
Design: systematic review Participants: 17 Evidence: high
Full summary, score breakdown and related studies → Original source
Transferring a lifestyle intervention from a trial-setting to real life requires knowledge about the factors that influence effective implementation. 1 key finding →
Design: randomized controlled trial Participants: 27 Evidence: high
Full summary, score breakdown and related studies → Original source
Our study confirmed the effectiveness of psychosocial interventions for improving cognition or slowing down the progression of cognitive impairment in AD patients and recommended several interventions for clinical practice. 3 key findings →
Design: meta-analysis Participants: 682 Evidence: high
Full summary, score breakdown and related studies → Original source
A 6-week robot-assisted, multi-domain cognitive training program can improve the efficiency of global cognitive function and depression during cognitive tasks in older adults with MCI, which is associated with improvements in memory and executive function. 2 key findings →
Design: randomized controlled trial Participants: 90 Evidence: high
Full summary, score breakdown and related studies → Original source
27-OH appears to be a marker not only for dementia/AD risk, but also for monitoring the effects of preventive interventions on cholesterol metabolism. 3 key findings →
Design: cross-sectional Participants: 47 Evidence: high
Full summary, score breakdown and related studies → Original source
This review suggests the advantage of combined interventions over exercise with comparable effects when compared with cognitive interventions in the population with mild cognitive impairment and dementia. 4 key findings →
Design: meta-analysis Participants: 2,910 Evidence: high
Full summary, score breakdown and related studies → Original source
The results obtained will provide information on the applicability of these multidomain intervention programs to at-risk elderly people. 1 key finding →
Design: randomized controlled trial Participants: 150 Evidence: high
Full summary, score breakdown and related studies → Original source
Greater MIND diet adherence was associated with decreased risk of cognitive impairment in female participants but not male participants, with no difference between Black participants and White participants. 5 key findings →
Design: cohort study Participants: 14,145 Evidence: moderate
Full summary, score breakdown and related studies → Original source
Obesity has been linked to cognitive impairment, cognitive decline and dementia. 1 key finding →
Design: randomized controlled trial Participants: 180 Evidence: high
Full summary, score breakdown and related studies → Original source
A 28% increase in CSF DHA and 43% increase in CSF EPA were observed in the DHA treatment arm compared to placebo (mean difference for DHA (95% CI): 0.08 µg/mL (0.05, 0.10), p<0.0001; mean difference for EPA: 0.008 µg/mL (0.004, 0.011), p<0.0001). 2 key findings →
Participants: 33 Evidence: high
Full summary, score breakdown and related studies → Original source
From across this tag
10 of the 1,868 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- Physical and cognitive training are able to prevent recognition memory deficits related to amyloid beta neurotoxicity
- Adherence to Mediterranean diet and subjective cognitive function in men
- Association of 3-Year Multidomain Intervention and Omega-3 Supplementation with Frailty Incidence
- Relationship Between Exercise and Alzheimer's Disease: A Narrative Literature Review
- Sleepiness, sleep time, and depression of caregivers are linked with sleep and behaviors of their paired partners with dementia
- PCSK9 and High-Fat Diet Synergistically Induce Neurovascular Dysfunction and Neuroinflammation
- Healthy dietary intake diminishes the effect of cerebral small vessel disease on cognitive performance in older adults
- Role of diet and exercise in aging, Alzheimer's disease, and other chronic diseases
- Effect of physical activity on risk of Alzheimer's disease: A systematic review and meta-analysis of twenty-nine prospective cohort studies
- Associations Between Sleep‐Disordered Breathing, Nocturnal Hypoxemia, and Subsequent Cognitive Decline in Older Community‐Dwelling Men: The Osteoporotic Fractures in Men Sleep Study
Where “Free full text” comes from
Free full text links and the Full text may need a subscription label come from Unpaywall, Europe PMC and OpenAlex records of free copies, checked 10 Oct 2026. A study with neither is unknown, not paywalled. Show only studies that are free to read
How the 0–100 score works — and why some entries are capped
This is alzhub's own score. It is not an official metric, not an impact factor, and no journal, publisher or ranking body endorses it. We built it so that a reader who is not a scientist can tell a landmark trial from a conference abstract without having to already know the difference. Every point comes from one of 20 components, all of them printed on the study itself, so you can disagree with our arithmetic rather than having to trust the total.
- Journal tier up to 10 pts
- Journal's citation record up to 4 pts
- Study design up to 12 pts
- Strength of evidence up to 5 pts
- Peer-review validation up to 10 pts
- How recent up to 5 pts
- Sample size up to 4 pts
- Effect reported up to 3 pts
- Studied in people up to 3 pts
- Randomised / blinded up to 2 pts
- Times cited up to 7 pts
- Citations per year up to 5 pts
- Impact for its field and year up to 6 pts
- Cited by studies here up to 6 pts
- Still being cited up to 4 pts
- Senior author's track record up to 4 pts
- Institution's track record up to 3 pts
- Multi-centre collaboration up to 3 pts
- Indexed in PubMed up to 2 pts
- Free to read up to 2 pts
Journals are placed in ordered tiers, never given a numeric impact factor — we could not verify current impact factors from a source we control, and an invented one would be worse than none. Tier 1 is the top-tier general journals (NEJM, The Lancet, JAMA, Nature, Science, Nature Medicine); tier 2 is the leading specialty journals; tier 3 is every other peer-reviewed journal. A separate part scores how much the journal's own papers are cited, which tells the tier-3 journals apart.
Two rules we don't bend. First, we never fill in a missing value: if a record does not state a sample size or a design, that component scores zero, and if we simply have no data for a part, such as a citation count, that part is left out and the study is scored on the parts we could check. The study card says which. Second, anything that is not a peer-reviewed article is capped at 16/100 and carries a warning chip — so a conference abstract or a company press release can never outrank a peer-reviewed paper, no matter how good it looks.
We rank a rigorous null result — a good trial showing that something does not work — above an early positive finding. Someone deciding whether to buy a supplement is served by that, and the rigour is already counted by the design and journal components.
The score is computed from the published data alone and is reproducible: the same file always yields the same numbers.
See the whole rubric drawn out → — four charts covering all 28,180 studies: how the scores are spread and where the cap bites, which of the 20 components the library is strong and weak on, which subjects rest on stronger evidence, and what kinds of study each subject is actually built from.
What this library is — and isn't
This is a large sample of the Alzheimer's literature, not an exhaustive index of it. It holds 28,180 records, built mostly from automated pulls of Europe PMC (61.7% of the library) and OpenAlex (18.1%), plus smaller pulls from PubMed, Crossref and medRxiv. If a study, a drug, or a finding isn't here, that is not evidence it doesn't exist in the literature — it may simply not have been pulled in yet.
1,034 records (3.7% of the library) are not peer-reviewed — 962 of those are preprints posted before any journal review, and the rest are conference abstracts, regulatory notices and reports. Every study card on this page states its status plainly, and the score above is capped for anything that isn't a peer-reviewed article.
See the full, machine-readable breakdown of this library's coverage →