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vivo-imaging
4 studies tagged vivo-imaging, dated 2012-12-31 to 2022-07-08. Bibliography: BibTeX (.bib) · RIS (.ris)
Newest in this topic
- A quantitative in vivo imaging platform for tracking pathological tau depositions and resultant neuronal death in a mouse model 2022-07-08
- In vivo imaging of synaptic loss in Alzheimer's disease with [18F]UCB-H positron emission tomography 2019-08-29
- Cross-interaction of tau PET tracers with monoamine oxidase B: evidence from in silico modelling and in vivo imaging 2019-03-27
Studies
4 studies carry this tag.
Date range
2012 to 2022
Top journals
- European journal of nuclear medicine and molecular imaging 3
- PloS one 1
Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.
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Our imaging platform has enabled the quantification of tau depositions and consequent neuronal loss and is potentially applicable to the evaluation of candidate anti-tau and neuroprotective drugs.
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38/100
The findings thus highlight predominant synaptic loss in the hippocampus, confirming previous autopsy-based studies and a recent PET study with an 11C-labelled SV2A radiotracer. [18F]UCB-H PET allows to image in vivo synaptic changes in Alzheimer's disease and to relate them to patients' cognitive impairment.
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The developed tau tracers show in silico and in vivo evidence of cross-interaction with MAO-B; the MAO-B component of the tracer binding was dependent on the regional concentration of the enzyme.
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Tauopathies are widespread neurodegenerative disorders characterised by the intracellular accumulation of hyperphosphorylated tau.