toxic

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

1. 16/100

   Relationship Between Therapeutic Activity and Preferential Targeting of Toxic Soluble Aggregates by Amyloid-Beta-Directed Antibodies

   ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. bioRxiv · 2024-04-25 · Treatments

   Overall, these results suggest that selectivity for soluble toxic Aβ oligomers may be a driver of clinical efficacy, with a potentially reduced risk of ARIA if engagement with plaque is minimized.

   • Treatments
   • Brain Biology
2. 38/100

   Oleuropein aglycone and hydroxytyrosol interfere differently with toxic Aβ1-42 aggregation

   ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2019-04-14 · Treatments

   Oleuropein aglycone (OleA), the most abundant polyphenol in extra virgin olive oil (EVOO), and Hydroxythyrosol (HT), the OleA main metabolite, have attracted our interest due to their multitarget effects, including the interference with amyloid aggregation path.

   • Treatments
   • Brain Biology
3. 47/100

   Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector

   ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Nature medicine · 2018-04-09 · Genetics

   Efforts to develop drugs for Alzheimer's disease (AD) have shown promise in animal studies, only to fail in human trials, suggesting a pressing need to study AD in human model systems.

   • Genetics
   • Brain Biology
   • Treatments
4. 36/100

   The coexistence of an equal amount of Alzheimer's amyloid-β 40 and 42 forms structurally stable and toxic oligomers through a distinct pathway

   ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The FEBS journal · 2014-05-06 · Biomarkers

   Fibrillar amyloid-β (Aβ) is the major constituent of senile plaques in the brain of patients with Alzheimer's disease (AD).

   • Brain Biology
5. 40/100

   Exosomes: vehicles for the transfer of toxic proteins associated with neurodegenerative diseases?

   ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Frontiers in physiology · 2012-05-03 · Risk genes beyond APOE

   Exosomes are small membranous vesicles secreted by a number of cell types including neurons and can be isolated from conditioned cell media or bodily fluids such as urine and plasma.

   • Brain Biology
   • Treatments
6. 36/100

   Role of human aldo-keto-reductase AKR1B10 in the protection against toxic aldehydes

   ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Chemico-biological interactions · 2008-11-01 · Brain scans and imaging

   Damage of cell membranes by reactive oxygen species results in the formation of toxic lipid peroxides which may ultimately lead to cell death.

7. 36/100

   Acetylcholinesterase-Abeta complexes are more toxic than Abeta fibrils in rat hippocampus: effect on rat beta-amyloid aggregation, laminin expression, reactive astrocytosis, and neuronal cell loss

   ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The American journal of pathology · 2004-06-01 · Biomarkers

   Neuropathological changes generated by human amyloid-beta peptide (Abeta) fibrils and Abeta-acetylcholinesterase (Abeta-AChE) complexes were compared in rat hippocampus in vivo.

   • Brain Biology

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