alzhub.org
Get help now — free helplines

You can call any of these for free. You do not need a diagnosis, an appointment, or a crisis to call — questions and plain exhaustion are reasons enough.

  • Alzheimer's Association 24/7 Helpline 800-272-3900 24 hours a day, 365 days a year Free, confidential support and information for people with dementia, caregivers, families and the public. Master's-level clinicians. Also Spanish.
  • 988 Suicide & Crisis Lifeline 988 24/7 Call or text 988, or chat at 988lifeline.org. For anyone in emotional distress or a mental-health crisis, including caregivers.
  • Alzheimer's Foundation of America (AFA) Helpline 866-232-8484 9:00 am - 9:00 pm ET, seven days a week Licensed social workers providing support, info and referrals. Also text message and web chat. Text: 646-586-5283

In a medical emergency, call 911. More numbers, and what each line does, on the help page.

Home › Research › Topics › proteostasis

proteostasis

240 studies tagged proteostasis, dated 1993-05-01 to 2026-10-30. Bibliography: BibTeX (.bib) · RIS (.ris)

Newest in this topic

  1. Disrupting SORL1-retromer endosomal recycling in mice drives the age-dependent neurodegenerative signature of Alzheimer's disease 2026-10-30
  2. TMEM106B C-Terminal fragment aggregation exacerbates α-synuclein and TDP-43 proteinopathy phenotypes 2026-10-30
  3. The Filamin A Proteomic Switch: Solubility States and Cytoskeletal Dynamics Explain the Inverse Epidemiological Relationship Between Cancer and Alzheimer’s Disease 2026-10-26

Studies

240 studies carry this tag.

Date range

1993 to 2026

Top journals

  • Autophagy 9
  • bioRxiv 9
  • Nature 8
  • Nature communications 6
  • Acta neuropathologica 5

145 journals in all.

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

  1. Proteomics of the lysosome

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Biochimica et biophysica acta 2008-10-15 Genetics

    Defects in lysosomal function have been associated with numerous monogenic human diseases typically classified as lysosomal storage diseases.

  2. Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The Journal of neuroscience : the official journal of the Society for Neuroscience 2008-07-01 Disease mechanisms

    Macroautophagy, a major pathway for organelle and protein turnover, has been implicated in the neurodegeneration of Alzheimer's disease (AD).

  3. Statins reduce neuronal alpha-synuclein aggregation in in vitro models of Parkinson's disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of neurochemistry 2008-01-28 Drug development

    Aggregation of alpha-synuclein (alpha-syn) is believed to play a critical role in the pathogenesis of disorders such as dementia with Lewy bodies and Parkinson's disease.

  4. Autophagy, amyloidogenesis and Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of cell science 2007-12-01 Disease mechanisms

    Autophagy is the sole pathway for organelle turnover in cells and is a vital pathway for degrading normal and aggregated proteins, particularly under stress or injury conditions.

  5. C-terminal truncations in human 3'-5' DNA exonuclease TREX1 cause autosomal dominant retinal vasculopathy with cerebral leukodystrophy

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Nature genetics 2007-07-29 Brain scans and imaging

    Autosomal dominant retinal vasculopathy with cerebral leukodystrophy is a microvascular endotheliopathy with middle-age onset.

  6. Neuropathology, biochemistry, and biophysics of alpha-synuclein aggregation

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of neurochemistry 2007-07-10 Lewy body dementia

    Aggregation of alpha-synuclein, an abundant and conserved pre-synaptic brain protein, is implicated as a critical factor in several neurodegenerative diseases.

  7. AGGRESCAN: a server for the prediction and evaluation of "hot spots" of aggregation in polypeptides

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. BMC bioinformatics 2007-02-27 How common it is

    By identifying aggregation-prone segments in proteins, AGGRESCAN http://bioinf.uab.es/aggrescan/ shall facilitate (i) the identification of possible therapeutic targets for anti-depositional strategies in conformational diseases and (ii) the anticipation of aggregation phenomena during storage or recombinant production of bioactive polypeptides or polypeptide sets.

  8. Proteomic Identification of Novel Proteins in Cortical Lewy Bodies

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Brain Pathology 2007-02-08 Genetics

    Lewy body (LB) inclusions are one of the pathological hallmarks of Parkinson's disease (PD) and dementia with Lewy bodies (DLB).

  9. ER stress and diseases

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The FEBS journal 2007-02-01 Risk factors

    Proteins synthesized in the endoplasmic reticulum (ER) are properly folded with the assistance of ER chaperones.

  10. Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Nature genetics 2006-09-10 Risk genes beyond APOE

    Neurodegenerative disorders such as Parkinson and Alzheimer disease cause motor and cognitive dysfunction and belong to a heterogeneous group of common and disabling disorders.

  11. S-nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Nature 2006-05-01 Disease mechanisms

    Stress proteins located in the cytosol or endoplasmic reticulum (ER) maintain cell homeostasis and afford tolerance to severe insults.

  12. The importance of sequence diversity in the aggregation and evolution of proteins

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Nature 2005-12-01 Prevention trials

    Incorrect folding of proteins, leading to aggregation and amyloid formation, is associated with a group of highly debilitating medical conditions including Alzheimer's disease and late-onset diabetes.

  13. Macroautophagy--a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. The Journal of cell biology 2005-10-03 Risk genes beyond APOE

    Macroautophagy, which is a lysosomal pathway for the turnover of organelles and long-lived proteins, is a key determinant of cell survival and longevity.

  14. Role of oxidative carbonylation in protein quality control and senescence

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The EMBO journal 2005-03-03 Disease mechanisms

    Proteins can become modified by a large number of reactions involving reactive oxygen species.

  15. Endosome function and dysfunction in Alzheimer's disease and other neurodegenerative diseases

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neurobiology of aging 2005-03-01 Down syndrome and Alzheimer's

    Endocytosis is universally important in cell function.

  16. Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of neuropathology and experimental neurology 2005-02-01 Brain tissue and pathology

    The accumulation of lysosomes and their hydrolases within neurons is a well-established neuropathologic feature of Alzheimer disease (AD).

  17. ER stress and the unfolded protein response

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Mutation research 2005-01-01 Risk factors

    Conformational diseases are caused by mutations altering the folding pathway or final conformation of a protein.

  18. Cell biology of protein misfolding: the examples of Alzheimer's and Parkinson's diseases

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Nature cell biology 2004-11-01 Risk genes beyond APOE

    The salutary intersection of fundamental cell biology with the study of disease is well illustrated by the emerging elucidation of neurodegenerative disorders.

  19. Hsp70 Reduces α-Synuclein Aggregation and Toxicity

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Journal of Biological Chemistry 2004-06-01 Brain tissue and pathology

    Aggregation and cytotoxicity of misfolded alpha-synuclein is postulated to be crucial in the disease process of neurodegenerative disorders such as Parkinson's disease and DLB (dementia with Lewy bodies).

  20. Raman Spectroscopic Characterization of Secondary Structure in Natively Unfolded Proteins: α-Synuclein

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of the American Chemical Society 2004-02-04 Brain tissue and pathology

    The application of Raman spectroscopy to characterize natively unfolded proteins has been underdeveloped, even though it has significant technical advantages.

  21. The ubiquitin proteasome system in neurodegenerative diseases: sometimes the chicken, sometimes the egg

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neuron 2003-10-01 Disease mechanisms

    The ubiquitin-proteasome system targets numerous cellular proteins for degradation.

  22. Protein aggregation and aggregate toxicity: new insights into protein folding, misfolding diseases and biological evolution

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of molecular medicine (Berlin, Germany) 2003-08-27 Disease mechanisms

    The deposition of proteins in the form of amyloid fibrils and plaques is the characteristic feature of more than 20 degenerative conditions affecting either the central nervous system or a variety of peripheral tissues.

  23. A Broken α-Helix in Folded α-Synuclein

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Journal of Biological Chemistry 2003-04-01 Brain tissue and pathology

    alpha-Synuclein is a small cytosolic protein of presynaptic nerve terminals composed of seven 11-residue repeats and a hydrophilic tail. alpha-Synuclein misfolding and dysfunction may contribute to the pathogenesis of Parkinson's disease and neurodegenerative dementias, but its normal folding and function are unknown.

  24. Synergistic effects of pesticides and metals on the fibrillation of alpha-synuclein: implications for Parkinson's disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neurotoxicology 2002-10-01 Risk factors

    Aggregation of alpha-synuclein has been implicated in the formation of proteinaceous inclusions in the brain (Lewy bodies, Lewy neurites) that are characteristic of neurodegenerative diseases, such as Parkinson's disease (PD) and dementia with Lewy bodies (DLBs).

  25. Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Human molecular genetics 2002-05-01 Disease mechanisms

    Protein conformational disorders (PCDs), such as Alzheimer's disease, Huntington's disease (HD), Parkinson's disease and oculopharyngeal muscular dystrophy, are associated with proteins that misfold and aggregate.

  26. alpha-Synuclein is phosphorylated in synucleinopathy lesions

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Nature cell biology 2002-02-01 Brain tissue and pathology

    The deposition of the abundant presynaptic brain protein alpha-synuclein as fibrillary aggregates in neurons or glial cells is a hallmark lesion in a subset of neurodegenerative disorders.

  27. The synucleins

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Genome biology 2001-12-20 Brain scans and imaging

    Synucleins are small, soluble proteins expressed primarily in neural tissue and in certain tumors.

  28. Evidence for a partially folded intermediate in alpha-synuclein fibril formation

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The Journal of biological chemistry 2001-01-10 Brain tissue and pathology

    Intracellular proteinaceous aggregates (Lewy bodies and Lewy neurites) of alpha-synuclein are hallmarks of neurodegenerative diseases such as Parkinson's disease, dementia with Lewy bodies, and multiple systemic atrophy.

  29. Mitotic activation: a convergent mechanism for a cohort of neurodegenerative diseases

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neurobiology of aging 2000-11-01 Down syndrome and Alzheimer's

    Previous evidence from our lab and others has implicated the mitotic cdc2/cyclin B1 kinase in the neurofibrillary degeneration of Alzheimer's disease.

  30. α-Synuclein Membrane Interactions and Lipid Specificity

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Journal of Biological Chemistry 2000-11-01 Risk genes beyond APOE

    With the discovery of missense mutations (A53T and A30P) in alpha-synuclein (alpha-Syn) in several families with early onset familial Parkinson's disease, alpha-Syn aggregation and fibril formation have been thought to play a role in the pathogenesis of alpha-synucleinopathies, such as Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy.

  31. Synucleins are developmentally expressed, and alpha-synuclein regulates the size of the presynaptic vesicular pool in primary hippocampal neurons

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The Journal of neuroscience : the official journal of the Society for Neuroscience 2000-05-01 Drug development

    alpha-, beta-, and gamma-Synuclein, a novel family of neuronal proteins, has become the focus of research interest because alpha-synuclein has been increasingly implicated in the pathogenesis of Parkinson's and Alzheimer's disease.

  32. Fiber diffraction of synthetic alpha-synuclein filaments shows amyloid-like cross-beta conformation

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Proceedings of the National Academy of Sciences of the United States of America 2000-04-01 Brain tissue and pathology

    Filamentous inclusions made of alpha-synuclein constitute the defining neuropathological characteristic of Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy.

  33. Fibrils formed in vitro from alpha-synuclein and two mutant forms linked to Parkinson's disease are typical amyloid

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Biochemistry 2000-03-01 Risk genes beyond APOE

    Two missense mutations in the gene encoding alpha-synuclein have been linked to rare, early-onset forms of Parkinson's disease (PD).

  34. The alpha-synucleinopathies: Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Annals of the New York Academy of Sciences 2000-01-01 Lewy body dementia

    Parkinson's disease is the second most common neurodegenerative disease, after Alzheimer's disease.

  35. Classification of sporadic Creutzfeldt-Jakob disease based on molecular and phenotypic analysis of 300 subjects

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Annals of neurology 1999-08-01 Brain tissue and pathology

    Phenotypic heterogeneity in sporadic Creutzfeldt-Jakob disease (sCJD) is well documented, but there is not yet a systematic classification of the disease variants.

  36. α-Synuclein Shares Physical and Functional Homology with 14-3-3 Proteins

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Journal of Neuroscience 1999-07-15 Brain tissue and pathology

    alpha-Synuclein has been implicated in the pathophysiology of many neurodegenerative diseases, including Parkinson's disease (PD) and Alzheimer's disease.

  37. Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble α‐synuclein

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Annals of Neurology 1998-09-01 Brain tissue and pathology

    Recently, alpha-synuclein was shown to be a structural component of the filaments in Lewy bodies (LBs) of Parkinson's disease (PD), dementia with LBs (DLB) as well as the LB variant of Alzheimer's disease, and this suggests that alpha-synuclein could play a mechanistic role in the pathogenesis of these disorders.

  38. Stabilization of alpha-synuclein secondary structure upon binding to synthetic membranes

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The Journal of biological chemistry 1998-04-01 Brain tissue and pathology

    alpha-Synuclein is a highly conserved presynaptic protein of unknown function.

  39. Alzheimer presenilins in the nuclear membrane, interphase kinetochores, and centrosomes suggest a role in chromosome segregation

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Cell 1997-09-01 Down syndrome and Alzheimer's

    Mutations in two related genes, presenilin 1 and 2, account for most early-onset familial Alzheimer's disease.

  40. Continuous c-fos expression precedes programmed cell death in vivo

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Nature 1993-05-01 Brain scans and imaging

    The development of a multicellular organism involves a delicate balance among the processes of proliferation, differentiation and death.

From across this tag

6 of the 240 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 6. The same 6 appear here every time.

All topic tags with their study counts