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Home › Research › Topics › precursor

precursor

1,346 studies tagged precursor, dated 1982-09-01 to 2026-10-18. Bibliography: BibTeX (.bib) · RIS (.ris)

Newest in this topic

  1. Evidence for Reduced Somatic T-Cell Receptor Sequence Diversity Profiles Among Midwestern Amish in an Aging Cohort Study 2026-10-18
  2. Gantenerumab reduces brain amyloid-β proteoforms: Biochemical evaluation in dominantly inherited Alzheimer disease 2026-09-29
  3. Genetic Insights Into Protective Effects of GLP-1 Receptor Agonists on Stroke and Alzheimer Disease Across Ancestries 2026-09-25

Studies

1,346 studies carry this tag.

Date range

1982 to 2026

Top journals

  • Neurology 92
  • The Journal of biological chemistry 67
  • Proceedings of the National Academy of Sciences of the United States of America 47
  • Archives of neurology 43
  • JAMA neurology 36

372 journals in all.

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

  1. APOE-ε2 and APOE-ε4 correlate with increased amyloid accumulation in cerebral vasculature

    ✓ Peer-reviewed alzhub usefulness score 49 out of 100. Journal of neuropathology and experimental neurology 2013-07-01 Genetics

    The APOE-ε4 allele correlates with increased risk of Alzheimer disease (AD) and increased parenchymal amyloid plaques.

  2. In vivo radioligand binding to translocator protein correlates with severity of Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 63 out of 100. Brain : a journal of neurology 2013-06-17 Caregiving

    Partial volume corrected and uncorrected results were generally in agreement; however, the correlation between (11)C-PBR28 and (11)C-Pittsburgh Compound B binding was seen only after partial volume correction.

  3. Inflammatory proteins in plasma are associated with severity of Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 65 out of 100. PloS one 2013-06-10 Mild cognitive impairment

    Markers of Alzheimer's disease (AD) are being widely sought with a number of studies suggesting blood measures of inflammatory proteins as putative biomarkers.

  4. C9orf72 hexanucleotide repeat expansions in clinical Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 56 out of 100. JAMA neurology 2013-06-01 Risk genes beyond APOE

    Hexanucleotide repeat expansions in the chromosome 9 open reading frame 72 (C9orf72) gene underlie a significant fraction of frontotemporal dementia and amyotrophic lateral sclerosis.

  5. Differential relationships of reactive astrocytes and microglia to fibrillar amyloid deposits in Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 63 out of 100. Journal of neuropathology and experimental neurology 2013-06-01 Inflammation and the immune system

    Although it is clear that astrocytes and microglia cluster around dense-core amyloid plaques in Alzheimer disease (AD), whether they are primarily attracted to amyloid deposits or are just reacting to plaque-associated neuritic damage remains elusive.

  6. The amyloid precursor protein: a biochemical enigma in brain development, function and disease

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. FEBS letters 2013-05-16 Risk genes beyond APOE

    For 20 years the amyloid cascade hypothesis of Alzheimer disease (AD) has placed the amyloid-β peptide (Aβ), formed from the amyloid precursor protein (APP), centre stage in the process of neurodegeneration.

  7. Alzheimer’s Disease Risk Gene CD33 Inhibits Microglial Uptake of Amyloid Beta

    ✓ Peer-reviewed alzhub usefulness score 59 out of 100. Neuron 2013-04-25 Risk genes beyond APOE

  8. Altered expression of diabetes-related genes in Alzheimer's disease brains: the Hisayama study

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. Cerebral cortex (New York, N.Y. : 1991) 2013-04-17 Risk factors

    Diabetes mellitus (DM) is considered to be a risk factor for dementia including Alzheimer's disease (AD).

  9. Metabolic networks underlying cognitive reserve in prodromal Alzheimer disease: a European Alzheimer disease consortium project

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2013-04-16 Brain scans and imaging

    The clusters of significant depression and compensation were further used as volumetric regions of interest (ROIs) in a brain interregional correlation analysis in each prodromal AD subgroup to explore metabolic connectivity.

  10. Complement receptor 1 coding variant p.Ser1610Thr in Alzheimer's disease and related endophenotypes

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Neurobiology of aging 2013-04-10 Tau biomarkers

    We previously described an intragenic functional copy number variation (CNV) in complement receptor 1 (CR1) that is associated with Alzheimer disease (AD) risk.

  11. Functional impairment of microglia coincides with Beta-amyloid deposition in mice with Alzheimer-like pathology

    ✓ Peer-reviewed alzhub usefulness score 52 out of 100. PloS one 2013-04-08 Inflammation and the immune system

    Microglial cells closely interact with senile plaques in Alzheimer's disease and acquire the morphological appearance of an activated phenotype.

  12. Increased blood-brain barrier vulnerability to systemic inflammation in an Alzheimer disease mouse model

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Neurobiology of aging 2013-04-02 Risk genes beyond APOE

    Behavioral and psychological problems are often observed in patients with dementia such as that associated with Alzheimer disease, and these noncognitive symptoms place an extremely heavy burden on the family and caregivers.

  13. SORL1 is genetically associated with late-onset Alzheimer's disease in Japanese, Koreans and Caucasians

    ✓ Peer-reviewed alzhub usefulness score 69 out of 100. PloS one 2013-04-02 Genetics

    To discover susceptibility genes of late-onset Alzheimer's disease (LOAD), we conducted a 3-stage genome-wide association study (GWAS) using three populations: Japanese from the Japanese Genetic Consortium for Alzheimer Disease (JGSCAD), Koreans, and Caucasians from the Alzheimer Disease Genetic Consortium (ADGC).

  14. Amyloid precursor protein controls cholesterol turnover needed for neuronal activity

    ✓ Peer-reviewed alzhub usefulness score 44 out of 100. EMBO molecular medicine 2013-04-01 Risk genes beyond APOE

    Perturbation of lipid metabolism favours progression of Alzheimer disease, in which processing of Amyloid Precursor Protein (APP) has important implications.

  15. Cerebrovascular effects of apolipoprotein E: implications for Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. JAMA neurology 2013-04-01 Genetics

    Human apolipoprotein E (apoE) has 3 isoforms: apoE2, apoE3, and apoE4.

  16. MicroRNA-144 is regulated by activator protein-1 (AP-1) and decreases expression of Alzheimer disease-related a disintegrin and metalloprotease 10 (ADAM10)

    ✓ Peer-reviewed alzhub usefulness score 42 out of 100. The Journal of biological chemistry 2013-04-01 Risk genes beyond APOE

    MicroRNA (miR) dysregulation is found in Alzheimer disease (AD).

  17. Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E ϵ4,and the risk of late-onset Alzheimer disease in African Americans

    ✓ Peer-reviewed alzhub usefulness score 78 out of 100. JAMA 2013-04-01 Genetics

    Genome-wide significance in fully adjusted models (sex, age, APOE genotype, population stratification) was observed for a SNP in ABCA7 (rs115550680, allele = G; frequency, 0.09 cases and 0.06 controls; odds ratio [OR], 1.79 [95% CI, 1.47-2.12]; P = 2.2 × 10(-9)), which is in linkage disequilibrium with SNPs previously associated with Alzheimer disease in Europeans (0.8 Conclusions and relevance In this meta-analysis of data from African American participants, Alzheimer disease was significantly associated with variants in ABCA7 and with other genes that have been associated with Alzheimer disease in individuals of European ancestry.

  18. White matter hyperintensities and cerebral amyloidosis: necessary and sufficient for clinical expression of Alzheimer disease?

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. JAMA neurology 2013-04-01 Prevention and risk

    White matter hyperintensities contribute to the presentation of AD and, in the context of significant amyloid deposition, may provide a second hit necessary for the clinical manifestation of the disease.

  19. Amyloid β deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: a prospective cohort study

    ✓ Peer-reviewed alzhub usefulness score 74 out of 100. The Lancet. Neurology 2013-03-08 Caregiving

    At baseline, significantly higher Aβ burdens were noted in patients with AD (2·27, SD 0·43) and those with MCI (1·94, 0·64) than in healthy controls (1·38, 0·39).

  20. Posterior cingulate glucose metabolism, hippocampal glucose metabolism, and hippocampal volume in cognitively normal, late-middle-aged persons at 3 levels of genetic risk for Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 58 out of 100. JAMA neurology 2013-03-01 Genetics

    Although there were no significant differences among the 3 groups of participants in their clinical ratings, neuropsychological test scores, hippocampal volumes (P = .60), or hippocampal glucose metabolism measurements (P = .12), there were significant group differences in their posterior cingulate glucose metabolism measurements (P = .001).

  21. Brain β-amyloid load approaches a plateau

    ✓ Peer-reviewed alzhub usefulness score 60 out of 100. Neurology 2013-02-27 Biomarkers

    This roughly 15-year interval where the slope of the amyloid SUVR vs time curve is greatest and roughly linear represents a large therapeutic window for secondary preventive interventions.

  22. Amyloid β-peptide (1-42)-induced oxidative stress in Alzheimer disease: importance in disease pathogenesis and progression

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Antioxidants & redox signaling 2013-02-14 Risk genes beyond APOE

    Alzheimer disease (AD) is an age-related neurodegenerative disease.

  23. Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology

    ✓ Peer-reviewed alzhub usefulness score 72 out of 100. Molecular psychiatry 2013-02-12 Genetics

    Genome-wide association studies (GWAS) have identified a region upstream the BIN1 gene as the most important genetic susceptibility locus in Alzheimer's disease (AD) after APOE.

  24. APOE ε4 increases risk for dementia in pure synucleinopathies

    ✓ Peer-reviewed alzhub usefulness score 69 out of 100. JAMA neurology 2013-02-01 Genetics

    The APOE ϵ4 allele is a strong risk factor across the LBD spectrum and occurs at an increased frequency in pDLB relative to PDD.

  25. Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

    ✓ Peer-reviewed alzhub usefulness score 56 out of 100. Nature reviews. Neurology 2013-01-08 Genetics

    Apolipoprotein E (Apo-E) is a major cholesterol carrier that supports lipid transport and injury repair in the brain.

  26. Levels of soluble apolipoprotein E/amyloid-β (Aβ) complex are reduced and oligomeric Aβ increased with APOE4 and Alzheimer disease in a transgenic mouse model and human samples

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. The Journal of biological chemistry 2013-01-04 Genetics

    Human apolipoprotein E (apoE) isoforms may differentially modulate amyloid-β (Aβ) levels.

  27. Mesenchymal stem cells enhance autophagy and increase β-amyloid clearance in Alzheimer disease models

    ✓ Peer-reviewed alzhub usefulness score 44 out of 100. Autophagy 2013-01-01 Brain tissue and pathology

    Current evidence suggests a central role for autophagy in Alzheimer disease (AD), and dysfunction in the autophagic system may lead to amyloid-β (Aβ) accumulation.

  28. Differential effect of APOE genotype on amyloid load and glucose metabolism in AD dementia

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Neurology 2012-12-19 Genetics

    These findings suggest that APOE genotype has a differential effect on the distribution of amyloid plaques and glucose metabolism.

  29. NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice

    ✓ Peer-reviewed alzhub usefulness score 62 out of 100. Nature 2012-12-19 Inflammation and the immune system

    Alzheimer's disease is the world's most common dementing illness.

  30. Amyloid is linked to cognitive decline in patients with Parkinson disease without dementia

    ✓ Peer-reviewed alzhub usefulness score 63 out of 100. Neurology 2012-12-12 Caregiving

    At baseline measurements, amyloid burden does not distinguish between cognitively impaired and unimpaired subjects with PD without dementia, but our data suggest that amyloid contributes to cognitive, but not motor, decline over time.

  31. Amyloid-β oligomerization in Alzheimer dementia versus high-pathology controls

    ✓ Peer-reviewed alzhub usefulness score 52 out of 100. Annals of neurology 2012-12-07 Risk genes beyond APOE

    Although amyloid-beta (Aβ) peptide deposition into insoluble plaques is a pathological hallmark of Alzheimer disease; soluble oligomeric Aβ has been hypothesized to more directly underlie impaired learning and memory in dementia of the Alzheimer type.

  32. Inhibition of GSK3β-mediated BACE1 expression reduces Alzheimer-associated phenotypes

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. The Journal of clinical investigation 2012-12-03 Risk genes beyond APOE

    Deposition of amyloid β protein (Aβ) to form neuritic plaques in the brain is the pathological hallmark of Alzheimer's disease (AD).

  33. Personality factors moderate the associations between apolipoprotein genotype and cognitive function as well as late onset Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 58 out of 100. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 2012-12-01 Treatments

    Phenotypic personality dimensions, primarily neuroticism and extraversion, moderate the relationship between APOE [Latin Small Letter Open E]-4 genotype and cognitive outcomes among older adults.

  34. Differential regulation of amyloid-β endocytic trafficking and lysosomal degradation by apolipoprotein E isoforms

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. The Journal of biological chemistry 2012-11-06 Genetics

    Aggregation of amyloid-β (Aβ) peptides leads to synaptic disruption and neurodegeneration in Alzheimer disease (AD).

  35. Effects of APOE on brain white matter microstructure in healthy adults

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Neurology 2012-10-24 Genetics

    APOE affects microstructural properties of the brain WM from early adulthood, but the specific allelic effects do not directly reflect the associated risk of developing Alzheimer disease.

  36. APOE4-specific changes in Aβ accumulation in a new transgenic mouse model of Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. The Journal of biological chemistry 2012-10-11 Genetics

    APOE4 is the greatest risk factor for Alzheimer disease (AD) and synergistic effects with amyloid-β peptide (Aβ) suggest interactions among apoE isoforms and different forms of Aβ accumulation.

  37. Astrocytes: conductors of the Alzheimer disease neuroinflammatory symphony

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Experimental neurology 2012-10-11 Inflammation and the immune system

    Alzheimer disease (AD) is the most prevalent cause of dementia in humans, and the symptoms are commonly manifested after the seventh decade of life.

  38. Apolipoprotein E, especially apolipoprotein E4, increases the oligomerization of amyloid β peptide

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. The Journal of neuroscience : the official journal of the Society for Neuroscience 2012-10-01 Caregiving

    Alzheimer's disease (AD) is the most common progressive neurodegenerative disorder causing dementia.

  39. Comprehensive search for Alzheimer disease susceptibility loci in the APOE region

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. Archives of neurology 2012-10-01 Genetics

    APOE alleles ε2, ε3, and ε4 account for essentially all the inherited risk of AD associated with this region.

  40. Cathepsin B degrades amyloid-β in mice expressing wild-type human amyloid precursor protein

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. The Journal of biological chemistry 2012-09-28 Risk genes beyond APOE

    Accumulation of amyloid-β (Aβ), believed to be a key trigger of Alzheimer disease (AD), could result from impaired clearance mechanisms.

  41. δ-Catenin is genetically and biologically associated with cortical cataract and future Alzheimer-related structural and functional brain changes

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. PloS one 2012-09-11 Brain scans and imaging

    Multiple lines of evidence suggest that specific subtypes of age-related cataract (ARC) and Alzheimer disease (AD) are related etiologically.

  42. Metal dyshomeostasis and oxidative stress in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Neurochemistry international 2012-09-08 Caregiving

    Alzheimer's disease is the leading cause of dementia in the elderly and is defined by two pathological hallmarks; the accumulation of aggregated amyloid beta and excessively phosphorylated Tau proteins.

  43. Mitochondria-associated ER membranes in Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Molecular and cellular neurosciences 2012-08-24 Brain scans and imaging

    Alzheimer disease (AD) is associated with the accumulation in the brain of extracellular neuritic plaques composed mainly of β-amyloid (Aβ) and of intracellular neurofibrillary tangles composed of hyperphosphorylated forms of the microtubule-associated protein tau.

  44. Activity dependent degeneration explains hub vulnerability in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. PLoS computational biology 2012-08-16 Brain scans and imaging

    Brain connectivity studies have revealed that highly connected 'hub' regions are particularly vulnerable to Alzheimer pathology: they show marked amyloid-β deposition at an early stage.

  45. Upregulated function of mitochondria-associated ER membranes in Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 56 out of 100. The EMBO journal 2012-08-14 Risk genes beyond APOE

    Alzheimer disease (AD) is associated with aberrant processing of the amyloid precursor protein (APP) by γ-secretase, via an unknown mechanism.

  46. Regional cerebral perfusion in patients with Alzheimer's disease and mild cognitive impairment: effect of APOE epsilon4 allele

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Neuroradiology 2012-07-25 Genetics

    The objective of this study was to evaluate the effect of apolipoprotein E (APOE) epsilon 4 allele on regional cerebral perfusion (rCBF) changes using arterial spin labeling (ASL) magnetic resonance imaging (MRI) in subjects who are carriers or noncarriers of this risk factor for Alzheimer disease (AD).

  47. Novel late-onset Alzheimer disease loci variants associate with brain gene expression

    ✓ Peer-reviewed alzhub usefulness score 62 out of 100. Neurology 2012-06-20 Genetics

    CLU and MS4A4A eSNPs may at least partly explain the LOAD risk association at these loci.

  48. Identification of Alzheimer disease-associated variants in genes that regulate retromer function

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Neurobiology of aging 2012-06-05 Risk genes beyond APOE

    The proteolytic processing of amyloid precursor protein (APP) to generate the neurotoxic amyloid β (Aβ) peptide is central to the pathogenesis of Alzheimer disease (AD).

  49. Apolipoprotein E ε4 and age effects on florbetapir positron emission tomography in healthy aging and Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 56 out of 100. Neurobiology of aging 2012-05-24 Brain scans and imaging

    Cerebral amyloid deposition is associated with APOE4 carrier status in older healthy control subjects and symptomatic AD patients, and increases with age in older cognitively normal individuals.

  50. Cigarette smoking accelerated brain aging and induced pre-Alzheimer-like neuropathology in rats

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. PloS one 2012-05-11 Risk genes beyond APOE

    Cigarette smoking has been proposed as a major risk factor for aging-related pathological changes and Alzheimer's disease (AD).

From across this tag

10 of the 1,344 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.

All topic tags with their study counts