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Home › Research › Topics › phosphorylation

phosphorylation

387 studies tagged phosphorylation, dated 1987-01-01 to 2026-10-31. Bibliography: BibTeX (.bib) · RIS (.ris)

Newest in this topic

  1. APH-1A and CDK5 Expression Correlates with Tau Hyperphosphorylation and Its Attenuation by Brahmi and Donep-M in STZ induced Alzheimer’s Disease Model 2026-10-31
  2. Opposing Regulation of Tau Condensation by Phosphorylation Levels and Molecular Chaperone Interactions 2026-10-30
  3. The Alzheimer's disease-associated rs28834970 variant in PTK2B impairs electrical activity and regulates Tau phosphorylation and APP processing in human neuronal cultures 2026-10-30

Studies

387 studies carry this tag.

Date range

1987 to 2026

Top journals

  • Acta neuropathologica 16
  • Alzheimer's & dementia : the journal of the Alzheimer's Association 12
  • bioRxiv 12
  • Molecular neurodegeneration 10
  • Research Square 10

173 journals in all.

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

  1. Phospho-tau/total tau ratio in cerebrospinal fluid discriminates Creutzfeldt-Jakob disease from other dementias

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Molecular psychiatry 2003-03 Tau biomarkers

    Early clinical symptoms of sporadic Creutzfeldt-Jakob disease (CJD) may overlap with other neurodegenerative diseases like Alzheimer's disease (AD) and frontotemporal degeneration (FTD).

  2. Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. The Journal of cell biology 2002-03-18 Risk genes beyond APOE

    We studied the effect of microtubule-associated tau protein on trafficking of vesicles and organelles in primary cortical neurons, retinal ganglion cells, and neuroblastoma cells.

  3. Correction of alternative splicing of tau in frontotemporal dementia and parkinsonism linked to chromosome 17

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. The Journal of biological chemistry 2001-09-17 Drug development

    Mutations in the human tau gene cause frontotemporal dementia and Parkinsonism associated with chromosome 17 (FTDP-17).

  4. Proapoptotic effects of tau cleavage product generated by caspase-3

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neurobiology of disease 2001-02-01 Drug development

    Using an in vitro translation assay to screen a human brain cDNA library, we isolated the microtubule-associated protein Tau and determined it to be a caspase-3 substrate whose C-terminal cleavage occurred during neuronal apoptosis.

  5. Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The EMBO journal 2001-01-01 Risk genes beyond APOE

    Glycogen synthase kinase-3beta (GSK-3beta) has been postulated to mediate Alzheimer's disease tau hyperphosphorylation, beta-amyloid-induced neurotoxicity and presenilin-1 mutation pathogenic effects.

  6. Glycogen synthase kinase-3beta phosphorylates protein tau and rescues the axonopathy in the central nervous system of human four-repeat tau transgenic mice

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The Journal of biological chemistry 2000-12-01 Drug development

    Protein tau filaments in brain of patients suffering from Alzheimer's disease, frontotemporal dementia, and other tauopathies consist of protein tau that is hyperphosphorylated.

  7. Casein kinase 1 delta is associated with pathological accumulation of tau in several neurodegenerative diseases

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neurobiology of aging 2000-07-01 Down syndrome and Alzheimer's

    The distribution of casein kinase 1 delta (Cki delta) was studied by immunohistochemistry and correlated with other pathological hallmarks in Alzheimer's disease (AD), Down syndrome (DS), progressive supranuclear palsy (PSP), parkinsonism dementia complex of Guam (PDC), Pick's disease (PiD), pallido-ponto-nigral degeneration (PPND), Parkinson's disease (PD), dementia with Lewy bodies (DLB), amyotrophic lateral sclerosis (ALS), and elderly controls.

  8. Astrocytes expressing hyperphosphorylated tau protein without glial fibrillary tangles in argyrophilic grain disease

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Acta neuropathologica 1999-09-01 Drug development

    Argyrophilic grain disease (AgD), a frequent type of late onset dementia, is characterized by the occurrence of Gallyas-stained neuropil grains in the hippocampus, entorhinal cortex, amygdala and hypothalamus.

  9. Lithium protects cultured neurons against beta-amyloid-induced neurodegeneration

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. FEBS letters 1999-06-01 Drug development

    The deposition of beta-amyloid peptide (A beta), the hyperphosphorylation of tau protein and the death of neurons in certain brain regions are characteristic features of Alzheimer's disease.

  10. Alz-50/Gallyas-positive lysosome-like intraneuronal granules in Alzheimer's disease and control brains

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Neuroscience letters 1998-12-18 Drug development

    The Gallyas-Braak silver impregnation method revealed neurons containing well-defined intraneuronal granules in both Alzheimer's disease and normal control brains.

  11. Overexpression of tau protein inhibits kinesin-dependent trafficking of vesicles, mitochondria, and endoplasmic reticulum: implications for Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. The Journal of cell biology 1998-11-01 Disease mechanisms

    The neuronal microtubule-associated protein tau plays an important role in establishing cell polarity by stabilizing axonal microtubules that serve as tracks for motor-protein-driven transport processes.

  12. Tau pathology in two Dutch families with mutations in the microtubule-binding region of tau

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The American journal of pathology 1998-11-01 Drug development

    Different mutations in the microtubule-associated tau protein gene have recently been identified in several families with hereditary frontotemporal dementia and Parkinsonism (FTDP-17) linked to chromosome 17q21-22.

  13. Activation of tau protein kinase I/glycogen synthase kinase-3beta by amyloid beta peptide (25-35) enhances phosphorylation of tau in hippocampal neurons

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neuroscience research 1998-08-01 Drug development

    According to the amyloid hypothesis for the pathogenesis of Alzheimer's disease (AD), amyloid beta peptide (Abeta) directly affects neurons, leading to neurodegeneration and tau phosphorylation, followed by the production of paired helical filaments (PHF) in neurofibrillary tangles (NFT).

  14. Lithium reduces tau phosphorylation by inhibition of glycogen synthase kinase-3

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The Journal of biological chemistry 1997-10-01 Drug development

    Lithium is one of the most widely used drugs for treating bipolar (manic-depressive) disorder.

  15. Lithium inhibits Alzheimer's disease-like tau protein phosphorylation in neurons

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. FEBS letters 1997-07-01 Drug development

    In Alzheimer's disease, tau protein becomes hyperphosporylated, which can contribute to neuronal degeneration.

  16. Phosphorylation of microtubule-associated protein tau by stress-activated protein kinases

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. FEBS letters 1997-06-01 Drug development

    The paired helical filament, which comprises the major fibrous element of the neurofibrillary lesions of Alzheimer's disease, is composed of hyperphosphorylated microtubule-associated protein tau.

  17. The heat shock-induced hyperphosphorylation of tau is estrogen-independent and prevented by androgens: implications for Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Proceedings of the National Academy of Sciences of the United States of America 1997-06-01 Drug development

    We have shown that heat shock induces rapid dephosphorylation of tau in both female and male rats followed by hyperphosphorylation only in female rats.

  18. Argyrophilic grain disease: widespread hyperphosphorylation of tau protein in limbic neurons

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Acta neuropathologica 1997-05-01 Drug development

    Argyrophilic grains (ArG) and coiled bodies of argyrophilic grain disease (AgD) and the neurofibrillary lesions of Alzheimer's disease (AD) share similar antigenic determinants, among them hyperphosphorylated microtubule-associated protein tau.

  19. Pick's disease: hyperphosphorylated tau protein segregates to the somatoaxonal compartment

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Acta neuropathologica 1996-12-01 Drug development

    Pick bodies and ballooned cells of Pick's disease and the neurofibrillary lesions of Alzheimer's disease are characterized by the presence of hyperphosphorylated microtubule-associated protein tau.

  20. Assembly of microtubule-associated protein tau into Alzheimer-like filaments induced by sulphated glycosaminoglycans

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Nature 1996-10-01 Brain tissue and pathology

    The paired helical filament (PHF) is the major component of the neurofibrillary deposits that form a defining neuropathological characteristic of Alzheimer's disease.

  21. Comparison of the neurofibrillary pathology in Alzheimer's disease and familial presenile dementia with tangles

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Acta neuropathologica 1996-07-01 Drug development

    Alzheimer's disease (AD) is characterised neuropathologically by the presence of abundant extracellular beta-amyloid deposits and intracellular neurofibrillary lesions consisting of neurofibrillary tangles, neuropil threads and senile plaque neurites which contain paired helical filaments (PHFs) made of hyperphosphorylated microtubule-associated protein tau.

  22. Neurofibrillary tangles of Alzheimer's disease brains contain 14-3-3 proteins

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neuroscience letters 1996-05-01 Drug development

    The localisation of 14-3-3 proteins compared to that of tau and ubiquitin-protein conjugates in sections of hippocampus from Alzheimer's disease (AD) brains was examined by immunohistochemistry.

  23. Characterization of mAb AP422, a novel phosphorylation-dependent monoclonal antibody against tau protein

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. FEBS letters 1996-04-01 Drug development

    A monoclonal antibody (AP422) specific for phosphoserine 422 in microtubule-associated protein tau has been produced.

  24. Glycogen synthase kinase-3 beta phosphorylates tau protein at multiple sites in intact cells

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neuroscience letters 1995-09-01 Drug development

    Hyperphosphorylated tau protein is the major constituent of the paired helical filament (PHF), the major fibrous component of the neurofibrillary lesions of Alzheimer's disease (AD).

  25. Monoclonal antibody AT8 recognises tau protein phosphorylated at both serine 202 and threonine 205

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neuroscience letters 1995-04-01 Drug development

    Hyperphosphorylated microtubule-associated protein tau is the major component of the paired helical filament of Alzheimer's disease.

  26. Immunoreactivity against tau, amyloid precursor protein, and beta-amyloid in the human retina

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Investigative ophthalmology & visual science 1995-01-01 Drug development

    The proteins investigated in this study are present in the human retina.

  27. Epitope mapping of monoclonal antibodies to the paired helical filaments of Alzheimer's disease: identification of phosphorylation sites in tau protein

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The Biochemical journal 1994-08-01 Drug development

    Tau is a neuronal phosphoprotein the expression of which is developmentally regulated.

  28. Identification of two distinct synucleins from human brain

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. FEBS letters 1994-05-01 Brain tissue and pathology

    Two abundant proteins of 140 and 134 amino acids were purified and sequenced from human brain.

  29. Microtubule-associated protein tau. Abnormal phosphorylation of a non-paired helical filament pool in Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The Journal of biological chemistry 1993-11-01 Biomarkers

    The major protein subunit of the paired helical filaments (PHF) of Alzheimer disease (AD) is the microtubule-associated protein tau.

  30. Recognition of the minimal epitope of monoclonal antibody Tau-1 depends upon the presence of a phosphate group but not its location

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of neuroscience research 1993-02-01 Drug development

    The major constituent of the paired helical filaments (PHFs) of Alzheimer's disease is the abnormally phosphorylated form of the microtubule-associated protein, tau.

  31. A68 proteins in Alzheimer's disease are composed of several tau isoforms in a phosphorylated state which affects their electrophoretic mobilities

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The Biochemical journal 1991-11-01 Drug development

    The tau-immunoreactive A68 polypeptides found in brains from patients with Alzheimer's disease have been studied by Western blotting using (1) antibodies to synthetic peptides corresponding to sequences that span the complete human tau molecule, and (2) antibodies specific for inserts 1 and 2 found towards the N-terminus of some tau isoforms.

  32. Hydrated autoclave pretreatment enhances tau immunoreactivity in formalin-fixed normal and Alzheimer's disease brain tissues

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Laboratory investigation; a journal of technical methods and pathology 1991-05-01 Drug development

    We developed a new immunohistochemical method by which normal tau antigenicity can be visualized in paraffin sections of formalin-fixed brain tissue.

  33. Tau in Alzheimer neurofibrillary tangles. N- and C-terminal regions are differentially associated with paired helical filaments and the location of a putative abnormal phosphorylation site

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The Biochemical journal 1991-01-01 Drug development

    To investigate the extent to which whole tau proteins, structurally abnormal tau and fragments of tau are incorporated into neurofibrillary tangles in Alzheimer's disease, an immunocytochemical mapping study using a panel of antibodies to several synthetic human tau peptides has been performed.

  34. Pathological proteins Tau 64 and 69 are specifically expressed in the somatodendritic domain of the degenerating cortical neurons during Alzheimer's disease. Demonstration with a panel of antibodies against Tau proteins

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Acta neuropathologica 1990-01-01 Drug development

    Bundles of paired helical filaments (PHF) accumulate in the pyramidal neurons that degenerate during Alzheimer's disease.

  35. Microtubule-associated polypeptides tau are altered in Alzheimer paired helical filaments

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Brain research 1988-08-01 Drug development

    Antisera were raised in rabbits to purified bovine tau and to isolated Alzheimer paired helical filaments (PHF) washed with sodium dodecyl sulfate (SDS).

  36. Immunochemical and biochemical characterization of tau proteins in normal and Alzheimer's disease brains with Alz 50 and Tau-1

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The Journal of biological chemistry 1988-06-01 Drug development

    Microtubule-associated protein tau was characterized in 5 Alzheimer and 5 control brains using two monoclonal antibodies, Alz 50 and Tau-1.

  37. Alzheimer's neurofibrillary tangles contain unique epitopes and epitopes in common with the heat-stable microtubule associated proteins tau and MAP2

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The American journal of pathology 1987-01-01 Drug development

    Ten monoclonal antibodies raised against Alzheimer's neurofibrillary tangles (ANTs) were characterized for reactivity with heat-stable microtubule fractions from bovine and human brain.

From across this tag

9 of the 387 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 9. The same 9 appear here every time.

All topic tags with their study counts