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Home › Research › Topics › pet-tracer

pet-tracer

12 studies tagged pet-tracer, dated 2015-11-28 to 2022-11-29. Bibliography: BibTeX (.bib) · RIS (.ris)

Newest in this topic

  1. Discriminative binding of tau PET tracers PI2620, MK6240 and RO948 in Alzheimer's disease, corticobasal degeneration and progressive supranuclear palsy brains 2022-11-29
  2. Discriminatory ability of next-generation tau PET tracers for Alzheimer's disease 2021-09-01
  3. Cryptic Sites in Tau Fibrils Explain the Preferential Binding of the AV-1451 PET Tracer toward Alzheimer's Tauopathy 2021-06-21

Studies

12 studies carry this tag.

Date range

2015 to 2022

Top journals

  • European journal of nuclear medicine and molecular imaging 5
  • ACS chemical neuroscience 2
  • Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2
  • Alzheimer's & dementia : the journal of the Alzheimer's Association 1
  • Brain : a journal of neurology 1

6 journals in all.

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

  1. Discriminative binding of tau PET tracers PI2620, MK6240 and RO948 in Alzheimer's disease, corticobasal degeneration and progressive supranuclear palsy brains

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Molecular psychiatry 2022-11-29 Brain scans and imaging

    Recent mechanistic and structural studies have challenged the classical tauopathy classification approach and revealed the complexity and heterogeneity of tau pathology in Alzheimer's disease (AD) and primary tauopathies such as corticobasal degeneration (CBD) and progressive supranuclear palsy (PSP), progressing beyond distinct tau isoforms.

  2. Discriminatory ability of next-generation tau PET tracers for Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. Brain : a journal of neurology 2021-09-01 Brain scans and imaging

    A next generation of tau PET tracers for the imaging of Alzheimer's disease and other dementias has recently been developed.

  3. Cryptic Sites in Tau Fibrils Explain the Preferential Binding of the AV-1451 PET Tracer toward Alzheimer's Tauopathy

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. ACS chemical neuroscience 2021-06-21 Brain scans and imaging

    In contrast, tau tracer AV-1451 is reported to bind to specific types of tau fibrils (in particular to AD-associated and CTE) with higher binding affinity and only show nonspecific or weaker binding toward tau fibrils dominant with 3R isoforms (associated with PiD).

  4. A multicenter comparison of [18F]flortaucipir, [18F]RO948, and [18F]MK6240 tau PET tracers to detect a common target ROI for differential diagnosis

    ✓ Peer-reviewed alzhub usefulness score 52 out of 100. European journal of nuclear medicine and molecular imaging 2021-05-27 Brain scans and imaging

    The temporal meta-ROI can be used for differential diagnosis of dementia patients with [ 18 F]flortaucipir, [ 18 F]RO948, and [ 18 F]MK6240 tau PET with high accuracy, and that using very similar cut-offs of around 1.35 SUVR.

  5. Towards clinical application of tau PET tracers for diagnosing dementia due to Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Alzheimer's & dementia : the journal of the Alzheimer's Association 2021-05-13 Brain scans and imaging

    The recent development of several tau positron emission tomography (PET) tracers represents a major milestone for the Alzheimer's disease (AD) field.

  6. Clinical validity of second-generation tau PET tracers as biomarkers for Alzheimer's disease in the context of a structured 5-phase development framework

    ✓ Peer-reviewed alzhub usefulness score 59 out of 100. European journal of nuclear medicine and molecular imaging 2021-02-16 Brain scans and imaging

    The current literature provides overall preliminary evidence on the establishment of the second-generation tau PET tracers into the clinical context, thereby successfully addressing some methodological issues from the tau PET tracer of the first generation.

  7. Characterization of MK6240, a tau PET tracer, in autopsy brain tissue from Alzheimer's disease cases

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. European journal of nuclear medicine and molecular imaging 2020-09-24 Brain scans and imaging

    3 H-MK6240 has a high binding affinity for tau deposits in AD brain tissue but also has different binding characteristics from those of the first-generation tau tracers.

  8. Computational Insight into the Binding Profile of the Second-Generation PET Tracer PI2620 with Tau Fibrils

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. ACS chemical neuroscience 2020-02-28 Brain scans and imaging

    Abnormal deposition of hyperphosphorylated tau as neurofibrillary tangles (NFTs) is an important pathological hallmark of Alzheimer's disease (AD) and of other neurodegenerative disorders.

  9. Cross-interaction of tau PET tracers with monoamine oxidase B: evidence from in silico modelling and in vivo imaging

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. European journal of nuclear medicine and molecular imaging 2019-03-27 Brain scans and imaging

    The developed tau tracers show in silico and in vivo evidence of cross-interaction with MAO-B; the MAO-B component of the tracer binding was dependent on the regional concentration of the enzyme.

  10. Preclinical Evaluation of 18F-JNJ64349311, a Novel PET Tracer for Tau Imaging

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2017-02-23 Brain scans and imaging

    Mouse biodistribution studies showed moderate initial brain uptake and rapid brain washout.

  11. Kinetic Modeling of the Tau PET Tracer 18F-AV-1451 in Human Healthy Volunteers and Alzheimer Disease Subjects

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2016-12-01 Brain scans and imaging

    AD demonstrated increased 18 F-AV-1451 retention compared with YHV and AHV based on both invasive and noninvasive analyses in cortical regions in which paired helical filament tau accumulation is expected in AD.

  12. Diagnostic accuracy of (18)F amyloid PET tracers for the diagnosis of Alzheimer's disease: a systematic review and meta-analysis

    ✓ Peer-reviewed alzhub usefulness score 67 out of 100. European journal of nuclear medicine and molecular imaging 2015-11-28 Brain scans and imaging

    Imaging or tissue biomarker evidence has been introduced into the core diagnostic pathway for Alzheimer's disease (AD).

All topic tags with their study counts