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Home › Research › Topics › loss

loss

11 studies tagged loss, dated 2004-08-01 to 2023-08-02. Bibliography: BibTeX (.bib) · RIS (.ris)

Newest in this topic

  1. Human Alzheimer's disease reactive astrocytes exhibit a loss of homeostastic gene expression 2023-08-02
  2. MRI and fluid biomarkers reveal determinants of myelin and axonal loss with aging 2023-02-10
  3. Suppression of Fli-1 protects against pericyte loss and cognitive deficits in Alzheimer's disease 2022-01-14

Studies

11 studies carry this tag.

Date range

2004 to 2023

Top journals

  • Neurobiology of aging 2
  • Neuron 2
  • Acta neuropathologica communications 1
  • Alzheimer's research & therapy 1
  • Annals of clinical and translational neurology 1

9 journals in all.

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

  1. Human Alzheimer's disease reactive astrocytes exhibit a loss of homeostastic gene expression

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Acta neuropathologica communications 2023-08-02 Biomarkers

    Astrocytes are one of the brain's major cell types and are responsible for maintaining neuronal homeostasis via regulating the extracellular environment, providing metabolic support, and modulating synaptic activity.

  2. MRI and fluid biomarkers reveal determinants of myelin and axonal loss with aging

    ✓ Peer-reviewed alzhub usefulness score 52 out of 100. Annals of clinical and translational neurology 2023-02-10 Biomarkers

    Plasma biomarkers of neuronal injury and astrogliosis are associated with reduced axonal density and region-specific myelin content.

  3. Suppression of Fli-1 protects against pericyte loss and cognitive deficits in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Molecular therapy : the journal of the American Society of Gene Therapy 2022-01-14 Drug development

    Brain pericytes regulate cerebral blood flow, maintain the integrity of the blood-brain barrier (BBB), and facilitate the removal of amyloid β (Aβ), which is critical to healthy brain activity.

  4. Loss of function of the mitochondrial peptidase PITRM1 induces proteotoxic stress and Alzheimer's disease-like pathology in human cerebral organoids

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Molecular psychiatry 2020-07-07 Genetics

    Mutations in pitrilysin metallopeptidase 1 (PITRM1), a mitochondrial protease involved in mitochondrial precursor processing and degradation, result in a slow-progressing syndrome characterized by cerebellar ataxia, psychotic episodes, and obsessive behavior, as well as cognitive decline.

  5. The clinical promise of biomarkers of synapse damage or loss in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Alzheimer's research & therapy 2020-03-02 Tau biomarkers

    A number of emerging biomarkers are able to measure synapse injury and loss in the brain and may correlate with cognitive function in AD.

  6. Loss of Trem2 in microglia leads to widespread disruption of cell coexpression networks in mouse brain

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Neurobiology of aging 2018-05-17 TREM2 and immune genetics

    Rare heterozygous coding variants in the triggering receptor expressed in myeloid cells 2 (TREM2) gene, conferring increased risk of developing late-onset Alzheimer's disease, have been identified.

  7. Loss of TMEM106B Ameliorates Lysosomal and Frontotemporal Dementia-Related Phenotypes in Progranulin-Deficient Mice

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Neuron 2017-07-01 Genetics

    Progranulin (GRN) and TMEM106B are associated with several common neurodegenerative disorders including frontotemporal lobar degeneration (FTLD).

  8. Loss of Aβ43 Production Caused by Presenilin-1 Mutations in the Knockin Mouse Brain

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neuron 2016-04-01 Biomarkers

    We recently reported that homozygous Presenilin-1 (Psen1) knockin (KI) mice carrying the familial Alzheimer's disease (FAD) mutation L435F or C410Y recapitulate the phenotypes of Psen1(-/-) mice.

  9. Loss of Bace2 in zebrafish affects melanocyte migration and is distinct from Bace1 knock out phenotypes

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of neurochemistry 2013-03-11 Treatments

    Alzheimer's disease is the most frequent dementia.

  10. Hypocretin (orexin) loss in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Neurobiology of aging 2011-05-05 Tau biomarkers

    Sleep disturbances in Alzheimer's disease (AD) patients are associated with the severity of dementia and are often the primary reason for institutionalization.

  11. Loss of apolipoprotein E receptor LR11 in Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Archives of neurology 2004-08-01 Genetics

    There is loss of the microarray-derived candidate, LR11, in neurons of AD brains.

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