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Home › Research › Topics › frontotemporal

frontotemporal

1,022 studies tagged frontotemporal, dated 1967-05-01 to 2026-09-22. Bibliography: BibTeX (.bib) · RIS (.ris)

Newest in this topic

  1. The value of a family history to distinguish monogenic from polygenic amyotrophic lateral sclerosis 2026-09-22
  2. Smartphone Passive Digital Phenotyping in Frontotemporal Lobar Degeneration 2026-09-21
  3. Diagnostic Value of Large Language Model-Extracted Gross Brain Findings in Neurodegenerative Diseases 2026-09-14

Studies

1,022 studies carry this tag.

Date range

1967 to 2026

Top journals

  • Neurology 106
  • Brain : a journal of neurology 71
  • Movement disorders : official journal of the Movement Disorder Society 53
  • Annals of neurology 34
  • The Lancet. Neurology 34

313 journals in all.

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

  1. Sequential distribution of pTDP-43 pathology in behavioral variant frontotemporal dementia (bvFTD)

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. Acta neuropathologica 2014-01-10 Caregiving

    We examined regional distribution patterns of phosphorylated 43-kDa TAR DNA-binding protein (pTDP-43) intraneuronal inclusions in frontotemporal lobar degeneration (FTLD).

  2. Predictors of cognitive impairment in an early stage Parkinson's disease cohort

    ✓ Peer-reviewed alzhub usefulness score 66 out of 100. Movement disorders : official journal of the Movement Disorder Society 2014-01-06 Cognitive tests and assessment

    The impact of Parkinson's disease (PD) dementia is substantial and has major functional and socioeconomic consequences.

  3. Multiple organ involvement by alpha-synuclein pathology in Lewy body disorders

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. Movement disorders : official journal of the Movement Disorder Society 2014-01-02 Getting a diagnosis

    Lewy body (LB) diseases are characterized by alpha-synuclein (AS) aggregates in the central nervous system (CNS).

  4. Parkinson's disease: a review

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Frontiers in bioscience (Scholar edition) 2014-01-01 How common it is

    Parkinson's Disease is the second most common progressive neurodegenerative disorder affecting older American adults and is predicted to increase in prevalence as the United States population ages.

  5. Tools and talk: an evolutionary perspective on the functional deficits associated with amyotrophic lateral sclerosis

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Muscle & nerve 2013-12-18 Digital health tools

    We propose that amyotrophic lateral sclerosis (ALS), and frontotemporal dementia may be viewed as a failure of interlinked functional complexes having their origins in key evolutionary adaptations.

  6. Disparities in deep brain stimulation surgery among insured elders with Parkinson disease

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. Neurology 2013-12-11 Disparities

    Among elderly Medicare beneficiaries with PD, race, sex, and neighborhood SES are strong independent predictors of DBS receipt.

  7. Confluence of α-synuclein, tau, and β-amyloid pathologies in dementia with Lewy bodies

    ✓ Peer-reviewed alzhub usefulness score 49 out of 100. Journal of neuropathology and experimental neurology 2013-12-01 Genetics

    Dementia with Lewy bodies (DLB) is pathologically characterized by α-synuclein aggregates in the brain.

  8. A novel prion disease associated with diarrhea and autonomic neuropathy

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. The New England journal of medicine 2013-11-01 Disease mechanisms

    Abnormal forms of prion protein that were found in multiple peripheral tissues were associated with diarrhea, autonomic failure, and neuropathy.

  9. MRI and pathology of REM sleep behavior disorder in dementia with Lewy bodies

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. Neurology 2013-10-09 Digital health tools

    Patients with autopsy-confirmed low-, intermediate-, and high-likelihood DLB, according to the probability statement recommended by the third report of the DLB Consortium, and antemortem MRI, were identified (n = 75).

  10. Amyotrophic Lateral Sclerosis: An update for 2013 Clinical Features, Pathophysiology, Management and Therapeutic Trials

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Aging and disease 2013-10-01 End-of-life care

    Amyotrophic lateral sclerosis (ALS), first described by Jean-Martin Charcot in the 1870s, is an age-related disorder that leads to degeneration of motor neurons.

  11. Cognitive reserve in Parkinson's disease: a systematic review and meta-analysis

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. Parkinsonism & related disorders 2013-08-29 Cognitive tests and assessment

    The concept of cognitive reserve is proposed to explain the mismatch between the degree of pathological changes and their clinical manifestations and has been used to help understand the variation in the rate of cognitive decline and the development of dementias.

  12. Non-Alzheimer neurodegenerative pathologies and their combinations are more frequent than commonly believed in the elderly brain: a community-based autopsy series

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. Acta neuropathologica 2013-07-31 Brain tissue and pathology

    Neurodegenerative diseases are characterised by neuronal loss and cerebral deposition of proteins with altered physicochemical properties.

  13. Parkinson's disease dementia: convergence of α-synuclein, tau and amyloid-β pathologies

    ✓ Peer-reviewed alzhub usefulness score 54 out of 100. Nature reviews. Neuroscience 2013-07-31 Getting a diagnosis

    Dementia is increasingly being recognized in cases of Parkinson's disease (PD); such cases are termed PD dementia (PDD).

  14. Palliative care for Parkinson's disease: a summary of the evidence and future directions

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Palliative medicine 2013-07-09 End-of-life care

    Despite calls for improved access to palliative care for people with Parkinson's disease, services have been slow in developing.

  15. Prion-like properties of pathological TDP-43 aggregates from diseased brains

    ✓ Peer-reviewed alzhub usefulness score 51 out of 100. Cell reports 2013-07-03 Lewy body dementia

    TDP-43 is the major component protein of ubiquitin-positive inclusions in brains of patients with frontotemporal lobar degeneration (FTLD-TDP) or amyotrophic lateral sclerosis (ALS).

  16. Homozygosity for the C9orf72 GGGGCC repeat expansion in frontotemporal dementia

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Acta neuropathologica 2013-07-02 Clinical safety

    An expanded hexanucleotide repeat in the C9orf72 gene is the most common genetic cause of frontotemporal dementia and amyotrophic lateral sclerosis (c9FTD/ALS).

  17. Differential central pathology and cognitive impairment in pre-diabetic and diabetic mice

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. Psychoneuroendocrinology 2013-06-21 Prevention and risk

    Although age remains the main risk factor to suffer Alzheimer's disease (AD) and vascular dementia (VD), type 2 diabetes (T2D) has turned up as a relevant risk factor for dementia.

  18. The CamPaIGN study of Parkinson's disease: 10-year outlook in an incident population-based cohort

    ✓ Peer-reviewed alzhub usefulness score 59 out of 100. Journal of neurology, neurosurgery, and psychiatry 2013-06-18 Getting a diagnosis

    (1) outlook in PD is heterogeneous, with most dying or developing dementia or postural instability by 10 years from diagnosis, but a quarter still doing well, with preserved mobility and intact cognition; (2) death is not directly related to PD in the majority; (3) baseline clinical and genetic variables are predictive of outcome and may be helpful in selecting patients for clinical trials.

  19. A multicenter study of glucocerebrosidase mutations in dementia with Lewy bodies

    ✓ Peer-reviewed alzhub usefulness score 71 out of 100. JAMA neurology 2013-06-01 Getting a diagnosis

    We found a significant association between GBA1 mutation carrier status and DLB, with an odds ratio of 8.28 (95% CI, 4.78-14.88).

  20. BDNF-based synaptic repair as a disease-modifying strategy for neurodegenerative diseases

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Nature reviews. Neuroscience 2013-05-15 Hippocampus size on brain scans

    Increasing evidence suggests that synaptic dysfunction is a key pathophysiological hallmark in neurodegenerative disorders, including Alzheimer's disease.

  21. Recurrent seizures, progressive cognitive decline, Parkinsonism and a calcified brain: is it Fahr's disease?

    ✓ Peer-reviewed alzhub usefulness score 27 out of 100. BMJ Case Reports 2013-05-09 Risk factors

    A 34-year-old man developed three generalised seizures over a period of 2 weeks.

  22. Neuropathologic basis of age-associated brain atrophy

    ✓ Peer-reviewed alzhub usefulness score 54 out of 100. JAMA neurology 2013-05-01 Genetics

    Ventricular volume trajectory is more sensitive than total brain and hippocampal volume trajectories as a marker of accruing Alzheimer disease and vascular pathology in elderly individuals.

  23. TARDBP and FUS mutations associated with amyotrophic lateral sclerosis: summary and update

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. Human mutation 2013-04-29 Brain tissue and pathology

    Mutations in the TAR DNA Binding Protein gene (TARDBP), encoding the protein TDP-43, were identified in amyotrophic lateral sclerosis (ALS) patients.

  24. Neurodegenerative disease status and post-mortem pathology in idiopathic rapid-eye-movement sleep behaviour disorder: an observational cohort study

    ✓ Peer-reviewed alzhub usefulness score 59 out of 100. The Lancet. Neurology 2013-04-03 Getting a diagnosis

    Our findings indicate that in most patients diagnosed with IRBD this parasomnia represents the prodromal phase of a Lewy body disorder.

  25. Clinical diagnostic criteria and classification controversies in frontotemporal lobar degeneration

    ✓ Peer-reviewed alzhub usefulness score 42 out of 100. International review of psychiatry (Abingdon, England) 2013-04-01 Digital health tools

    Frontotemporal lobar degeneration (FTLD) can manifest as a spectrum of clinical syndromes, ranging from behavioural impairment to language or motor dysfunction.

  26. The prevalence and incidence of dementia with Lewy bodies: a systematic review of population and clinical studies

    ✓ Peer-reviewed alzhub usefulness score 65 out of 100. Psychological medicine 2013-03-25 Getting a diagnosis

    DLB currently accounts for around one in 25 dementia cases diagnosed in the community and one in 13 cases in secondary care.

  27. Changes in cognition and behaviour in amyotrophic lateral sclerosis: nature of impairment and implications for assessment

    ✓ Peer-reviewed alzhub usefulness score 52 out of 100. The Lancet. Neurology 2013-03-18 Lewy body dementia

    Increased awareness of cognitive and behavioural change in amyotrophic lateral sclerosis has been driven by various clinic-based and population-based studies.

  28. Clinicopathologic correlations in 172 cases of rapid eye movement sleep behavior disorder with or without a coexisting neurologic disorder

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. Sleep medicine 2013-03-07 Risk factors

    In this large series of PSG-confirmed and probable RBD cases that underwent autopsy, the strong association of RBD with the synucleinopathies was further substantiated and a wider spectrum of disorders which can underlie RBD now are more apparent.

  29. Prion-like spreading of pathological α-synuclein in brain

    ✓ Peer-reviewed alzhub usefulness score 56 out of 100. Brain : a journal of neurology 2013-03-06 Lewy body dementia

    α-Synuclein is the major component of filamentous inclusions that constitute the defining characteristic of neurodegenerative α-synucleinopathies.

  30. Chronic neuropathologies of single and repetitive TBI: substrates of dementia?

    ✓ Peer-reviewed alzhub usefulness score 53 out of 100. Nature reviews. Neurology 2013-03-05 Getting a diagnosis

    Traumatic brain injury (TBI) has long been recognized to be a risk factor for dementia.

  31. Nonpharmacological enhancement of cognitive function in Parkinson's disease: a systematic review

    ✓ Peer-reviewed alzhub usefulness score 64 out of 100. Movement disorders : official journal of the Movement Disorder Society 2013-02-20 Prevention trials

    Cognitive decline and dementia are frequent in patients with Parkinson's disease (PD).

  32. Parkinson disease: an update

    ✓ Peer-reviewed alzhub usefulness score 33 out of 100. American family physician 2013-02-01 Digital health tools

    Parkinson disease is a progressive neurologic disorder afflicting approximately 1 percent of Americans older than 60 years.

  33. Criteria for the diagnosis of corticobasal degeneration

    ✓ Peer-reviewed alzhub usefulness score 61 out of 100. Neurology 2013-01-28 Getting a diagnosis

    Current criteria for the clinical diagnosis of pathologically confirmed corticobasal degeneration (CBD) no longer reflect the expanding understanding of this disease and its clinicopathologic correlations.

  34. Pattern of regional cortical thinning associated with cognitive deterioration in Parkinson's disease

    ✓ Peer-reviewed alzhub usefulness score 51 out of 100. PloS one 2013-01-24 Mild cognitive impairment

    The pattern of regional decreased cortical thickness that relates to cognitive deterioration is present in PD-MCI patients, involving areas that play a central role in the storage of prior experiences, integration of external perceptions, and semantic processing.

  35. Delayed emergence of a parkinsonian disorder or dementia in 81% of older men initially diagnosed with idiopathic rapid eye movement sleep behavior disorder: a 16-year update on a previously reported series

    ✓ Peer-reviewed alzhub usefulness score 56 out of 100. Sleep medicine 2013-01-22 Getting a diagnosis

    The vast majority of men > or =50 years old initially diagnosed with iRBD in this study eventually developed a parkinsonian disorder/dementia, often after a prolonged interval from onset of iRBD, with the mean interval being 14 years while the range extended to 29 years.

  36. Clinicopathologic differences among patients with behavioral variant frontotemporal dementia

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Neurology 2013-01-16 Digital health tools

    During life, patients with AD pathology may be misdiagnosed with bvFTD if they have an early age at onset and prominent neuropsychiatric features despite having greater memory difficulties and more intact personality and executive functions than patients with bvFTD-FTLD.

  37. Microglia, amyloid, and glucose metabolism in Parkinson's disease with and without dementia

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2012-12-06 Cognitive tests and assessment

    [(11)C](R)PK11195-PET measures upregulation of translocator protein, which is associated with microglial activation, [(11)C]PIB-PET is a marker of amyloid, while [(18)F]FDG-PET measures cerebral glucose metabolism (rCMRGlc).

  38. Investigation of c9orf72 in 4 neurodegenerative disorders

    ✓ Peer-reviewed alzhub usefulness score 52 out of 100. Archives of neurology 2012-12-01 Genetics

    The C9orf72 expansion is a common cause of ALS and FTLD, but not of AD or PD.

  39. Cognitive impairment in Parkinson disease: impact on quality of life, disability, and caregiver burden

    ✓ Peer-reviewed alzhub usefulness score 49 out of 100. Journal of geriatric psychiatry and neurology 2012-11-21 Caregiving

    Both quality of life and caregiver burden were similar in the 2 groups without dementia but were significantly different in those with PDD.

  40. The link between the GBA gene and parkinsonism

    ✓ Peer-reviewed alzhub usefulness score 51 out of 100. The Lancet. Neurology 2012-11-01 Lewy body dementia

    Mutations in the glucocerebrosidase (GBA) gene, which encodes the lysosomal enzyme that is deficient in Gaucher's disease, are important and common risk factors for Parkinson's disease and related disorders.

  41. Default network is not hypoactive in dementia with fluctuating cognition: an Alzheimer disease/dementia with Lewy bodies comparison

    ✓ Peer-reviewed alzhub usefulness score 42 out of 100. Neurobiology of aging 2012-10-11 Brain scans and imaging

    Default mode network resting state activity in posterior cingulate cortex is abnormally reduced in Alzheimer disease (AD) patients.

  42. Neuropathologic substrates of Parkinson disease dementia

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. Annals of neurology 2012-10-04 Getting a diagnosis

    Niney-two PD patients developed dementia, and 48 remained cognitively normal.

  43. Frontotemporal lobar degeneration: epidemiology, pathology, diagnosis and management

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. CNS drugs 2012-10-01 Digital health tools

    Frontotemporal lobar degeneration (FTLD) describes a spectrum of clinically, pathologically and genetically heterogeneous neurodegenerative disorders of unknown aetiology.

  44. My belief or yours? Differential theory of mind deficits in frontotemporal dementia and Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. Brain : a journal of neurology 2012-10-01 Disparities

    It has been suggested that a theory of mind deficit may account for some of the abnormalities in interpersonal behaviour that characterize patients affected by behavioural variant frontotemporal dementia.

  45. Pathologic accumulation of α-synuclein and Aβ in Parkinson disease patients with dementia

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Archives of neurology 2012-10-01 Disease mechanisms

    Dementia associated with PD has 2 major pathologic subgroups: neocortical synucleinopathy and neocortical synucleinopathy with Aβ deposition.

  46. The impact of autonomic dysfunction on survival in patients with dementia with Lewy bodies and Parkinson's disease with dementia

    ✓ Peer-reviewed alzhub usefulness score 62 out of 100. PloS one 2012-10-01 Clinical safety

    According to our findings, the identification of autonomic dysfunction seems to be of great importance in clinical practice, not only to avoid falls and other complications, but also as a possible predictor of survival.

  47. Progressive supranuclear palsy presenting as primary lateral sclerosis but lacking parkinsonism, gaze palsy, aphasia, or dementia

    ✓ Peer-reviewed alzhub usefulness score 42 out of 100. Journal of the neurological sciences 2012-09-29 Digital health tools

    We report an autopsy case of progressive supranuclear palsy (PSP) that clinically showed only slowly progressive and symmetric upper motor neuron syndrome over a disease course of 12 years.

  48. Neuropathologically defined subtypes of Alzheimer's disease differ significantly from neurofibrillary tangle-predominant dementia

    ✓ Peer-reviewed alzhub usefulness score 51 out of 100. Acta neuropathologica 2012-09-12 Digital health tools

    Alzheimer's disease (AD) can be classified based on the relative density of neurofibrillary tangles (NFTs) in the hippocampus and association cortices into three subtypes: typical AD, hippocampal-sparing AD (HpSp AD), and limbic-predominant AD (LP AD).

  49. Neuropathological correlates of dopaminergic imaging in Alzheimer's disease and Lewy body dementias

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Brain : a journal of neurology 2012-09-01 Caregiving

    Investigation of dopaminergic transporter loss in vivo using (123)I-N-fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl) nortropane single photon emission computed tomography has been widely used as a diagnostic aid in Lewy body disease.

  50. Characterizing dementia with Lewy bodies by means of diffusion tensor imaging

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. Neurology 2012-08-15 Brain scans and imaging

    Despite a similar level of dementia severity, patterns of DTI changes in AD and DLB differed significantly.

From across this tag

9 of the 1,021 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 9. The same 9 appear here every time.

All topic tags with their study counts