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Home › Research › Topics › dosage

dosage

80 studies tagged dosage, dated 1986-06-01 to 2026-08-06. Bibliography: BibTeX (.bib) · RIS (.ris)

Newest in this topic

  1. APP Dosage and Extracellular Domain Variants Drive Distinct Defects in Neurogenesis modeled in Down Syndrome iPS cells 2026-08-06
  2. Trisomy 21 cerebral organoids exhibit Alzheimer’s disease amyloid and apolipoprotein E co-pathologies 2026-07-07
  3. Prevalence of epilepsy and young-onset dementia in adults with intellectual disability: Contrasting Down syndrome and autism diagnoses 2026-06-15

Studies

80 studies carry this tag.

Date range

1986 to 2026

Top journals

  • Journal of Alzheimer's disease : JAD 4
  • bioRxiv 4
  • Alzheimer's & dementia : the journal of the Alzheimer's Association 3
  • Free radical biology & medicine 3
  • Mental retardation and developmental disabilities research reviews 3

59 journals in all.

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

  1. Function and regulation of Dyrk1A: towards understanding Down syndrome

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Cellular and molecular life sciences : CMLS 2009-08-14 Down syndrome and Alzheimer's

    Down syndrome (DS) is associated with a variety of symptoms, such as incapacitating mental retardation and neurodegeneration (i.e., Alzheimer's disease), that prevent patients from leading fully independent lives.

  2. Molecular genetic analysis of Down syndrome

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Human genetics 2009-06-13 Down syndrome and Alzheimer's

    Down syndrome (DS) is caused by trisomy of all or part of human chromosome 21 (HSA21) and is the most common genetic cause of significant intellectual disability.

  3. Down syndrome--recent progress and future prospects

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Human molecular genetics 2009-04-01 Down syndrome and Alzheimer's

    Down syndrome (DS) is caused by trisomy of chromosome 21 (Hsa21) and is associated with a number of deleterious phenotypes, including learning disability, heart defects, early-onset Alzheimer's disease and childhood leukaemia.

  4. Dual-specificity tyrosine(Y)-phosphorylation regulated kinase 1A-mediated phosphorylation of amyloid precursor protein: evidence for a functional link between Down syndrome and Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of neurochemistry 2007-11-14 Down syndrome and Alzheimer's

    Most individuals with Down Syndrome (DS) show an early-onset of Alzheimer's disease (AD), which potentially results from the presence of an extra copy of a segment of chromosome 21.

  5. Alzheimer's disease in Down syndrome: neurobiology and risk

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Mental retardation and developmental disabilities research reviews 2007-01-01 Down syndrome and Alzheimer's

    Down syndrome (DS) is characterized by increased mortality rates, both during early and later stages of life, and age-specific mortality risk remains higher in adults with DS compared with the overall population of people with mental retardation and with typically developing populations.

  6. Psychiatric and behavioral disorders in persons with Down syndrome

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Mental retardation and developmental disabilities research reviews 2007-01-01 Down syndrome and Alzheimer's

    Similar to the state of the broader intellectual disabilities field, many gaps exist in the research and treatment of mental health concerns in people with Down syndrome.

  7. Function and biological roles of the Dickkopf family of Wnt modulators

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Oncogene 2006-12-01 Brain scans and imaging

    Dickkopf (Dkk) genes comprise an evolutionary conserved small gene family of four members (Dkk1-4) and a unique Dkk3-related gene, Dkkl1 (soggy).

  8. BACE2, as a novel APP theta-secretase, is not responsible for the pathogenesis of Alzheimer's disease in Down syndrome

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006-07-01 Down syndrome and Alzheimer's

    Amyloid beta protein (Abeta), the major component of neuritic plaques in Alzheimer's disease (AD), is derived from APP by sequential cleavages of beta- and gamma-secretases.

  9. Cognitive executive function in Down's syndrome

    ✓ Peer-reviewed alzhub usefulness score 59 out of 100. The British journal of clinical psychology 2006-03-01 Down syndrome and Alzheimer's

    It is suggested that impaired executive function in Down's syndrome is due to abnormal development of the prefrontal cortex in Down's syndrome.

  10. App gene dosage modulates endosomal abnormalities of Alzheimer's disease in a segmental trisomy 16 mouse model of down syndrome

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The Journal of neuroscience : the official journal of the Society for Neuroscience 2003-07-01 Down syndrome and Alzheimer's

    Altered neuronal endocytosis is the earliest known pathology in sporadic Alzheimer's disease (AD) and Down syndrome (DS) brain and has been linked to increased Abeta production.

  11. Down's syndrome

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Lancet (London, England) 2003-04-01 Risk factors

    The sequencing of chromosome 21 and the use of models of Down's syndrome in mice have allowed us to relate genes and sets of genes to the neuropathogenesis of this syndrome, and to better understand its phenotype.

  12. Frontal cortex BDNF levels correlate with working memory in an animal model of Down syndrome

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Behavioural brain research 2003-02-01 Down syndrome and Alzheimer's

    Individuals with Down syndrome (DS) develop most neuropathological hallmarks of Alzheimer's disease early in life, including loss of cholinergic markers in the basal forebrain.

  13. Intraneuronal Abeta42 accumulation in Down syndrome brain

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 2002-06-01 Down syndrome and Alzheimer's

    Alzheimer's disease (AD) brains display A beta (Abeta) plaques, inflammatory changes and neurofibrillary tangles (NFTs).

  14. Drebrin, a dendritic spine protein, is manifold decreased in brains of patients with Alzheimer's disease and Down syndrome

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neuroscience letters 2002-05-01 Down syndrome and Alzheimer's

    Drebrin, located in the dendritic spines of the neuron, plays a role in the synaptic plasticity together with actin filaments.

  15. Procreative beneficence: why we should select the best children

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Bioethics 2001-10-01 Brain scans and imaging

    Eugenic selection of embryos is now possible by employing in vitro fertilization (IVF) and preimplantation genetic diagnosis (PGD).

  16. Health care management of adults with Down syndrome

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. American family physician 2001-09-01 Risk factors

    The family physician's holistic approach to patients forms the basis of good health care for adults with Down syndrome.

  17. Down syndrome and Alzheimer's disease: a link between development and aging

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Mental retardation and developmental disabilities research reviews 2001-01-01 Down syndrome and Alzheimer's

    A subset of aged individuals with Down syndrome (DS) exhibits the clinical features of Alzheimer's disease (AD) but our ability to detect dementia in this population is hampered by developmental differences as well as the sensitivity of existing test tools.

  18. DSCR1, overexpressed in Down syndrome, is an inhibitor of calcineurin-mediated signaling pathways

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Human molecular genetics 2000-07-01 Down syndrome and Alzheimer's

    Down syndrome is one of the major causes of mental retardation and congenital heart malformations.

  19. Reverse genetic analysis of Caenorhabditis elegans presenilins reveals redundant but unequal roles for sel-12 and hop-1 in Notch-pathway signaling

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Proceedings of the National Academy of Sciences of the United States of America 1999-03-01 Drug development

    Mutations in the human presenilin genes PS1 and PS2 cause early-onset Alzheimer's disease.

  20. Early amyloid deposition in the medial temporal lobe of young Down syndrome patients: a regional quantitative analysis

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Experimental neurology 1998-04-01 Down syndrome and Alzheimer's

    The presence of the neuropathological alterations of Alzheimer's disease (AD) in essentially all older Down syndrome (DS) patients suggests that the examination of younger DS patients may clarify the early pathological progression of AD.

  21. Frameshift mutants of beta amyloid precursor protein and ubiquitin-B in Alzheimer's and Down patients

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Science (New York, N.Y.) 1998-01-01 Down syndrome and Alzheimer's

    The cerebral cortex of Alzheimer's and Down syndrome patients is characterized by the presence of protein deposits in neurofibrillary tangles, neuritic plaques, and neuropil threads.

  22. Serum interleukin-6 levels correlate with the severity of dementia in Down syndrome and in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Acta neurologica Scandinavica 1997-10-01 Down syndrome and Alzheimer's

    These findings suggest a disease stage dependent general activation of the immune system both in sporadic AD and in DS with AD.

  23. Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Nature 1995-12-01 Down syndrome and Alzheimer's

    Down's syndrome (DS) or trisomy 21 is the most common genetic cause of mental retardation.

  24. Hypomethylation of the amyloid precursor protein gene in the brain of an Alzheimer's disease patient

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of molecular neuroscience : MN 1995-01-01 Down syndrome and Alzheimer's

    Aberrant expression of the amyloid precursor protein (APP) gene may contribute to the beta-amyloid deposition seen in Alzheimer's disease and Down syndrome patients.

  25. Introduction and expression of the 400 kilobase amyloid precursor protein gene in transgenic mice [corrected]

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Nature genetics 1993-09-01 Down syndrome and Alzheimer's

    Overexpression of the gene encoding the beta-amyloid precursor protein (APP) may have a key role in the pathogenesis of both Alzheimer's disease (AD) and Down Syndrome (DS).

  26. Psychiatric disorders in persons with Down syndrome

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. The Journal of nervous and mental disease 1991-10-01 Down syndrome and Alzheimer's

    This study was designed to provide information on the prevalence and nature of psychiatric disorders in 497 individuals with Down syndrome.

  27. The pattern of acquisition of plaques and tangles in the brains of patients under 50 years of age with Down's syndrome

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Journal of the neurological sciences 1989-02-01 Treatments

    The form and distribution of senile plaques (SP) and neurofibrillary tangles (NFT) has been examined in the brains of 13 patients with Down's syndrome (DS), aged less than or equal to 50 years, using immunocytochemical and silver staining procedures.

  28. Beta amyloid gene duplication in Alzheimer's disease and karyotypically normal Down syndrome

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Science (New York, N.Y.) 1987-03-01 Down syndrome and Alzheimer's

    With the recently cloned complementary DNA probe, lambda Am4 for the chromosome 21 gene encoding brain amyloid polypeptide (beta amyloid protein) of Alzheimer's disease, leukocyte DNA from three patients with sporadic Alzheimer's disease and two patients with karyotypically normal Down syndrome was found to contain three copies of this gene.

  29. The genetic defect causing familial Alzheimer's disease maps on chromosome 21

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Science (New York, N.Y.) 1987-02-01 Risk genes beyond APOE

    Alzheimer's disease is a leading cause of morbidity and mortality among the elderly.

  30. The neurobiologic consequences of Down syndrome

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Brain research bulletin 1986-06-01 Down syndrome and Alzheimer's

    Trisomy of the whole or distal part of human chromosome 21 (HSA 21) (Ts21) results in Down Syndrome (DS), which is characterized in part by mental retardation and associated neurological abnormalities.

From across this tag

5 of the 80 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 5. The same 5 appear here every time.

All topic tags with their study counts