% alzhub.org topic: dosage
% Source: https://alzhub.org/topic/dosage
% 80 entries, in the order the page lists them. Built from alzhub.org's own records.
% 0 entries have no readable author in the source record and carry no author field.

@article{valledor2026-f87dce03,
  author  = {Valledor, M. and Smith, K. and Lawrence, J. B. and Sosa, L. J.},
  title   = {{APP Dosage and Extracellular Domain Variants Drive Distinct Defects in Neurogenesis modeled in Down Syndrome iPS cells}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.08.05.742240},
  url     = {https://doi.org/10.64898/2026.08.05.742240}
}

@article{dooling2026-c6cd8c6a,
  author  = {Dooling, B. R. and Vielle, A. and Lucero, E. M. and Rydland, C. and Quang, D. and Summers, R. and Esquer, H. and Coughlan, C. and others},
  title   = {{Trisomy 21 cerebral organoids exhibit Alzheimer’s disease amyloid and apolipoprotein E co-pathologies}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.07.01.735908},
  url     = {https://doi.org/10.64898/2026.07.01.735908}
}

@article{lee2026-1135530e,
  author  = {Lee, N. R. and Tao, S. and Voltaire, S. and Bishop, L. and Esbensen, A. and Lee, B. and Shea, L. and Wallace, G.},
  title   = {{Prevalence of epilepsy and young-onset dementia in adults with intellectual disability: Contrasting Down syndrome and autism diagnoses}},
  journal = {PsyArXiv},
  year    = {2026},
  doi     = {10.31234/osf.io/647m3_v2},
  url     = {https://doi.org/10.31234/osf.io/647m3_v2}
}

@article{west2026-7b94cbdf,
  author  = {West, N. R. and Lindberg, M. F. and Dairou, J. and MacGregor, S. and Puthireddy, S. and Meijer, L. and Bhattacharyya, A.},
  title   = {{Leucettinib-21 decreases dosage effects of DYRK1A in human trisomy 21 iPSC-derived neural cells}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.02.05.704014},
  url     = {https://doi.org/10.64898/2026.02.05.704014}
}

@article{patel2025-c5fbe4fa,
  author  = {Patel, D. and Rakowiecki, K. and Lazarov, O.},
  title   = {{Amyloid precursor protein dosage normalization rescues neurogenesis and Alzheimer’s Disease phenotypes associated with Down Syndrome}},
  journal = {bioRxiv},
  year    = {2025},
  doi     = {10.1101/2025.07.30.667706},
  url     = {https://doi.org/10.1101/2025.07.30.667706}
}

@article{dunn2025-82cc99de,
  author  = {Dunn, L. N. and Niemeyer, B. F. and Eduthan, N. P. and Schade, K. A. and Waugh, K. A. and Brown, C. and Rachubinski, A. L. and Timkovich, A. E. and others},
  title   = {{Altered Hepatic Metabolism in Down Syndrome}},
  journal = {Cell reports},
  year    = {2025},
  doi     = {10.1101/2025.05.27.656393},
  url     = {https://doi.org/10.1101/2025.05.27.656393}
}

@article{baksh2023-37119823,
  author  = {Baksh, R. A. and Pape, S. E. and Chan, L. F. and Aslam, A. A. and Gulliford, M. C. and Strydom, A. and {GO-DS21 Consortium}},
  title   = {{Multiple morbidity across the lifespan in people with Down syndrome or intellectual disabilities: a population-based cohort study using electronic health records}},
  journal = {The Lancet. Public health},
  year    = {2023},
  doi     = {10.1016/s2468-2667(23)00057-9},
  pmid    = {37119823},
  url     = {https://doi.org/10.1016/s2468-2667(23)00057-9}
}

@article{iulita2023-37056479,
  author  = {Iulita, M. F. and Bejanin, A. and Vilaplana, E. and Carmona-Iragui, M. and Benejam, B. and Videla, L. and Barroeta, I. and Fernández, S. and others},
  title   = {{Association of biological sex with clinical outcomes and biomarkers of Alzheimer's disease in adults with Down syndrome}},
  journal = {Brain communications},
  year    = {2023},
  doi     = {10.1093/braincomms/fcad074},
  pmid    = {37056479},
  url     = {https://doi.org/10.1093/braincomms/fcad074}
}

@article{fleming2023-36565120,
  author  = {Fleming, Victoria and Helsel, Brian C and Ptomey, Lauren T and Rosas, H Diana and Handen, Benjamin and Laymon, Charles and Christian, Bradley T and Head, Elizabeth and others},
  title   = {{Weight Loss and Alzheimer's Disease in Down Syndrome}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2023},
  doi     = {10.3233/jad-220865},
  pmid    = {36565120},
  url     = {https://doi.org/10.3233/jad-220865}
}

@article{xu2022-35661546,
  author  = {Xu, Keren and Li, Shaobo and Muskens, Ivo S and Elliott, Natalina and Myint, Swe Swe and Pandey, Priyatama and Hansen, Helen M and Morimoto, Libby M and others},
  title   = {{Accelerated epigenetic aging in newborns with Down syndrome}},
  journal = {Aging cell},
  year    = {2022},
  doi     = {10.1111/acel.13652},
  pmid    = {35661546},
  url     = {https://doi.org/10.1111/acel.13652}
}

@article{ichimata2022-35311708,
  author  = {Ichimata, Shojiro and Yoshida, Koji and Visanji, Naomi P and Lang, Anthony E and Nishida, Naoki and Kovacs, Gabor G},
  title   = {{Patterns of Mixed Pathologies in Down Syndrome}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2022},
  doi     = {10.3233/jad-215675},
  pmid    = {35311708},
  url     = {https://doi.org/10.3233/jad-215675}
}

@article{palmer2021-34795060,
  author  = {Palmer, Carter R and Liu, Christine S and Romanow, William J and Lee, Ming-Hsiang and Chun, Jerold},
  title   = {{Altered cell and RNA isoform diversity in aging Down syndrome brains}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2021},
  doi     = {10.1073/pnas.2114326118},
  pmid    = {34795060},
  url     = {https://doi.org/10.1073/pnas.2114326118}
}

@article{johannesson2021-34091073,
  author  = {Johannesson, Malin and Sahlin, Charlotte and Söderberg, Linda and Basun, Hans and Fälting, Johanna and Möller, Christer and Zachrisson, Olof and Sunnemark, Dan and others},
  title   = {{Elevated soluble amyloid beta protofibrils in Down syndrome and Alzheimer's disease}},
  journal = {Molecular and cellular neurosciences},
  year    = {2021},
  doi     = {10.1016/j.mcn.2021.103641},
  pmid    = {34091073},
  url     = {https://doi.org/10.1016/j.mcn.2021.103641}
}

@article{csincsik2021-33748396,
  author  = {Csincsik, Lajos and Nelson, Rachel and Walpert, Madeleine J and Peto, Tunde and Holland, Anthony and Lengyel, Imre},
  title   = {{Increased choroidal thickness in adults with Down syndrome}},
  journal = {Alzheimer's \& dementia (Amsterdam, Netherlands)},
  year    = {2021},
  doi     = {10.1002/dad2.12170},
  pmid    = {33748396},
  url     = {https://doi.org/10.1002/dad2.12170}
}

@article{floresaguilar2020-33206953,
  author  = {Flores-Aguilar, L. and Iulita, M. F. and Kovecses, O. and Torres, M. D. and Levi, S. M. and Zhang, Y. and Askenazi, M. and Wisniewski, T. and others},
  title   = {{Evolution of neuroinflammation across the lifespan of individuals with Down syndrome}},
  journal = {Brain : a journal of neurology},
  year    = {2020},
  doi     = {10.1093/brain/awaa326},
  pmid    = {33206953},
  url     = {https://doi.org/10.1093/brain/awaa326}
}

@article{handen2020-32775597,
  author  = {Handen, B. L. and Lott, I. T. and Christian, B. T. and Schupf, N. and OBryant, S. and Mapstone, M. and Fagan, A. M. and Lee, J. H. and others},
  title   = {{The Alzheimer's Biomarker Consortium-Down Syndrome: Rationale and methodology}},
  journal = {Alzheimer's \& dementia (Amsterdam, Netherlands)},
  year    = {2020},
  doi     = {10.1002/dad2.12065},
  pmid    = {32775597},
  url     = {https://doi.org/10.1002/dad2.12065}
}

@article{jiang2019-31043483,
  author  = {Jiang, Y. and Sato, Y. and Im, E. and Berg, M. and Bordi, M. and Darji, S. and Kumar, A. and Mohan, P. S. and others},
  title   = {{Lysosomal Dysfunction in Down Syndrome Is APP-Dependent and Mediated by APP-βCTF (C99)}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2019},
  doi     = {10.1523/jneurosci.0578-19.2019},
  pmid    = {31043483},
  url     = {https://doi.org/10.1523/jneurosci.0578-19.2019}
}

@article{wiseman2018-29945247,
  author  = {Wiseman, F. K. and Pulford, L. J. and Barkus, C. and Liao, F. and Portelius, E. and Webb, R. and Chávez-Gutiérrez, L. and Cleverley, K. and others},
  title   = {{Trisomy of human chromosome 21 enhances amyloid-β deposition independently of an extra copy of APP}},
  journal = {Brain : a journal of neurology},
  year    = {2018},
  doi     = {10.1093/brain/awy159},
  pmid    = {29945247},
  url     = {https://doi.org/10.1093/brain/awy159}
}

@article{davidson2018-29973279,
  author  = {Davidson, Y. S. and Robinson, A. and Prasher, V. P. and Mann, D. M. A.},
  title   = {{The age of onset and evolution of Braak tangle stage and Thal amyloid pathology of Alzheimer's disease in individuals with Down syndrome}},
  journal = {Acta neuropathologica communications},
  year    = {2018},
  doi     = {10.1186/s40478-018-0559-4},
  pmid    = {29973279},
  url     = {https://doi.org/10.1186/s40478-018-0559-4}
}

@article{strydom2018-29631614,
  author  = {Strydom, A. and Heslegrave, A. and Startin, C. M. and Mok, K. Y. and Hardy, J. and Groet, J. and Nizetic, D. and Zetterberg, H. and others},
  title   = {{Neurofilament light as a blood biomarker for neurodegeneration in Down syndrome}},
  journal = {Alzheimer's research \& therapy},
  year    = {2018},
  doi     = {10.1186/s13195-018-0367-x},
  pmid    = {29631614},
  url     = {https://doi.org/10.1186/s13195-018-0367-x}
}

@article{izzo2018-30134785,
  author  = {Izzo, A. and Mollo, N. and Nitti, M. and Paladino, S. and Calì, G. and Genesio, R. and Bonfiglio, F. and Cicatiello, R. and others},
  title   = {{Mitochondrial dysfunction in down syndrome: molecular mechanisms and therapeutic targets}},
  journal = {Molecular medicine (Cambridge, Mass.)},
  year    = {2018},
  doi     = {10.1186/s10020-018-0004-y},
  pmid    = {30134785},
  url     = {https://doi.org/10.1186/s10020-018-0004-y}
}

@article{colacurcio2018-28988799,
  author  = {Colacurcio, D. J. and Pensalfini, A. and Jiang, Y. and Nixon, R. A.},
  title   = {{Dysfunction of autophagy and endosomal-lysosomal pathways: Roles in pathogenesis of Down syndrome and Alzheimer's Disease}},
  journal = {Free radical biology \& medicine},
  year    = {2018},
  doi     = {10.1016/j.freeradbiomed.2017.10.001},
  pmid    = {28988799},
  url     = {https://doi.org/10.1016/j.freeradbiomed.2017.10.001}
}

@article{torres2018-28965914,
  author  = {Torres, Maria D and Garcia, Octavio and Tang, Cindy and Busciglio, Jorge},
  title   = {{Dendritic spine pathology and thrombospondin-1 deficits in Down syndrome}},
  journal = {Free radical biology \& medicine},
  year    = {2018},
  doi     = {10.1016/j.freeradbiomed.2017.09.025},
  pmid    = {28965914},
  url     = {https://doi.org/10.1016/j.freeradbiomed.2017.09.025}
}

@article{zis2018-28870521,
  author  = {Zis, P. and Strydom, A.},
  title   = {{Clinical aspects and biomarkers of Alzheimer's disease in Down syndrome}},
  journal = {Free radical biology \& medicine},
  year    = {2018},
  doi     = {10.1016/j.freeradbiomed.2017.08.024},
  pmid    = {28870521},
  url     = {https://doi.org/10.1016/j.freeradbiomed.2017.08.024}
}

@article{tcw2017-28003277,
  author  = {Tcw, J. and Goate, A. M.},
  title   = {{Genetics of β-Amyloid Precursor Protein in Alzheimer's Disease}},
  journal = {Cold Spring Harbor perspectives in medicine},
  year    = {2017},
  doi     = {10.1101/cshperspect.a024539},
  pmid    = {28003277},
  url     = {https://doi.org/10.1101/cshperspect.a024539}
}

@article{cole2017-28482213,
  author  = {Cole, J. H. and Annus, T. and Wilson, L. R. and Remtulla, R. and Hong, Y. T. and Fryer, T. D. and Acosta-Cabronero, J. and Cardenas-Blanco, A. and others},
  title   = {{Brain-predicted age in Down syndrome is associated with beta amyloid deposition and cognitive decline}},
  journal = {Neurobiology of aging},
  year    = {2017},
  doi     = {10.1016/j.neurobiolaging.2017.04.006},
  pmid    = {28482213},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2017.04.006}
}

@article{doran2017-27983553,
  author  = {Doran, E. and Keator, D. and Head, E. and Phelan, M. J. and Kim, R. and Totoiu, M. and Barrio, JR. and Small, G. W. and others},
  title   = {{Down Syndrome, Partial Trisomy 21, and Absence of Alzheimer's Disease: The Role of APP}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2017},
  doi     = {10.3233/jad-160836},
  pmid    = {27983553},
  url     = {https://doi.org/10.3233/jad-160836}
}

@article{hamlett2017-27755974,
  author  = {Hamlett, E. D. and Goetzl, E. J. and Ledreux, A. and Vasilevko, V. and Boger, H. A. and LaRosa, A. and Clark, D. and Carroll, S. L. and others},
  title   = {{Neuronal exosomes reveal Alzheimer's disease biomarkers in Down syndrome}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2017},
  doi     = {10.1016/j.jalz.2016.08.012},
  pmid    = {27755974},
  url     = {https://doi.org/10.1016/j.jalz.2016.08.012}
}

@article{duchon2016-27375444,
  author  = {Duchon, A. and Herault, Y.},
  title   = {{DYRK1A, a Dosage-Sensitive Gene Involved in Neurodevelopmental Disorders, Is a Target for Drug Development in Down Syndrome}},
  journal = {Frontiers in behavioral neuroscience},
  year    = {2016},
  doi     = {10.3389/fnbeh.2016.00104},
  pmid    = {27375444},
  url     = {https://doi.org/10.3389/fnbeh.2016.00104}
}

@article{xu2016-27064279,
  author  = {Xu, W. and Weissmiller, A. M. and White, J. A. and Fang, F. and Wang, X. and Wu, Y. and Pearn, M. L. and Zhao, X. and others},
  title   = {{Amyloid precursor protein-mediated endocytic pathway disruption induces axonal dysfunction and neurodegeneration}},
  journal = {The Journal of clinical investigation},
  year    = {2016},
  doi     = {10.1172/jci82409},
  pmid    = {27064279},
  url     = {https://doi.org/10.1172/jci82409}
}

@article{karmiloffsmith2016-27019699,
  author  = {Karmiloff-Smith, A. and Al-Janabi, T. and D'Souza, H. and Groet, J. and Massand, E. and Mok, K. and Startin, C. and Fisher, E. and others},
  title   = {{The importance of understanding individual differences in Down syndrome}},
  journal = {F1000Research},
  year    = {2016},
  doi     = {10.12688/f1000research.7506.1},
  pmid    = {27019699},
  url     = {https://doi.org/10.12688/f1000research.7506.1}
}

@article{annus2016-26362596,
  author  = {Annus, T. and Wilson, L. R. and Hong, Y. T. and Acosta-Cabronero, J. and Fryer, T. D. and Cardenas-Blanco, A. and Smith, R. and Boros, I. and others},
  title   = {{The pattern of amyloid accumulation in the brains of adults with Down syndrome}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2016},
  doi     = {10.1016/j.jalz.2015.07.490},
  pmid    = {26362596},
  url     = {https://doi.org/10.1016/j.jalz.2015.07.490}
}

@article{kim2016-26194181,
  author  = {Kim, S. and Sato, Y. and Mohan, P. S. and Peterhoff, C. and Pensalfini, A. and Rigoglioso, A. and Jiang, Y. and Nixon, R. A.},
  title   = {{Evidence that the rab5 effector APPL1 mediates APP-βCTF-induced dysfunction of endosomes in Down syndrome and Alzheimer's disease}},
  journal = {Molecular psychiatry},
  year    = {2016},
  doi     = {10.1038/mp.2015.97},
  pmid    = {26194181},
  url     = {https://doi.org/10.1038/mp.2015.97}
}

@article{asim2015-26062604,
  author  = {Asim, A. and Kumar, A. and Muthuswamy, S. and Jain, S. and Agarwal, S.},
  title   = {{"Down syndrome: an insight of the disease"}},
  journal = {Journal of biomedical science},
  year    = {2015},
  doi     = {10.1186/s12929-015-0138-y},
  pmid    = {26062604},
  url     = {https://doi.org/10.1186/s12929-015-0138-y}
}

@article{grieco2015-25989505,
  author  = {Grieco, J. and Pulsifer, M. and Seligsohn, K. and Skotko, B. and Schwartz, A.},
  title   = {{Down syndrome: Cognitive and behavioral functioning across the lifespan}},
  journal = {American journal of medical genetics. Part C, Seminars in medical genetics},
  year    = {2015},
  doi     = {10.1002/ajmg.c.31439},
  pmid    = {25989505},
  url     = {https://doi.org/10.1002/ajmg.c.31439}
}

@article{goffinski2015-c6aa376b,
  author  = {Goffinski, Alida and Stanley, Maria A. and Shepherd, Nicole and Duvall, Nichole and Jenkinson, Sandra B. and Davis, Charlene and Bull, Marilyn J. and Roper, Randall J.},
  title   = {{Obstructive sleep apnea in young infants with Down Syndrome evaluated in a Down Syndrome specialty clinic}},
  journal = {American Journal of Medical Genetics Part A},
  year    = {2015},
  doi     = {10.1002/ajmg.a.36903},
  url     = {https://doi.org/10.1002/ajmg.a.36903}
}

@article{hartley2015-25510383,
  author  = {Hartley, D. and Blumenthal, T. and Carrillo, M. and DiPaolo, G. and Esralew, L. and Gardiner, K. and Granholm, A. C. and Iqbal, K. and others},
  title   = {{Down syndrome and Alzheimer's disease: Common pathways, common goals}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2015},
  doi     = {10.1016/j.jalz.2014.10.007},
  pmid    = {25510383},
  url     = {https://doi.org/10.1016/j.jalz.2014.10.007}
}

@article{iulita2014-24962069,
  author  = {Iulita, M. F. and Cuello, A. C.},
  title   = {{Nerve growth factor metabolic dysfunction in Alzheimer's disease and Down syndrome}},
  journal = {Trends in pharmacological sciences},
  year    = {2014},
  doi     = {10.1016/j.tips.2014.04.010},
  pmid    = {24962069},
  url     = {https://doi.org/10.1016/j.tips.2014.04.010}
}

@article{mccarron2014-23902161,
  author  = {McCarron, M. and McCallion, P. and Reilly, E. and Mulryan, N.},
  title   = {{A prospective 14-year longitudinal follow-up of dementia in persons with Down syndrome}},
  journal = {Journal of intellectual disability research : JIDR},
  year    = {2014},
  doi     = {10.1111/jir.12074},
  pmid    = {23902161},
  url     = {https://doi.org/10.1111/jir.12074}
}

@article{velazquez2013-23643842,
  author  = {Velazquez, R. and Ash, J. A. and Powers, B. E. and Kelley, C. M. and Strawderman, M. and Luscher, Z. I. and Ginsberg, S. D. and Mufson, E. J. and others},
  title   = {{Maternal choline supplementation improves spatial learning and adult hippocampal neurogenesis in the Ts65Dn mouse model of Down syndrome}},
  journal = {Neurobiology of disease},
  year    = {2013},
  doi     = {10.1016/j.nbd.2013.04.016},
  pmid    = {23643842},
  url     = {https://doi.org/10.1016/j.nbd.2013.04.016}
}

@article{glasson2014-23510031,
  author  = {Glasson, E. J. and Dye, D. E. and Bittles, A. H.},
  title   = {{The triple challenges associated with age-related comorbidities in Down syndrome}},
  journal = {Journal of intellectual disability research : JIDR},
  year    = {2014},
  doi     = {10.1111/jir.12026},
  pmid    = {23510031},
  url     = {https://doi.org/10.1111/jir.12026}
}

@article{englund2013-23436430,
  author  = {Englund, A. and Jonsson, B. and Zander, C. S. and Gustafsson, J. and Annerén, G.},
  title   = {{Changes in mortality and causes of death in the Swedish Down syndrome population}},
  journal = {American journal of medical genetics. Part A},
  year    = {2013},
  doi     = {10.1002/ajmg.a.35706},
  pmid    = {23436430},
  url     = {https://doi.org/10.1002/ajmg.a.35706}
}

@article{helguera2013-23312288,
  author  = {Helguera, P. and Seiglie, J. and Rodriguez, J. and Hanna, M. and Helguera, G. and Busciglio, J.},
  title   = {{Adaptive downregulation of mitochondrial function in down syndrome}},
  journal = {Cell metabolism},
  year    = {2013},
  doi     = {10.1016/j.cmet.2012.12.005},
  pmid    = {23312288},
  url     = {https://doi.org/10.1016/j.cmet.2012.12.005}
}

@article{zigman2013-23949829,
  author  = {Zigman, W. B.},
  title   = {{Atypical aging in Down syndrome}},
  journal = {Developmental disabilities research reviews},
  year    = {2013},
  doi     = {10.1002/ddrr.1128},
  pmid    = {23949829},
  url     = {https://doi.org/10.1002/ddrr.1128}
}

@article{shi2012-22344463,
  author  = {Shi, Y. and Kirwan, P. and Smith, J. and MacLean, G. and Orkin, S. H. and Livesey, F. J.},
  title   = {{A human stem cell model of early Alzheimer's disease pathology in Down syndrome}},
  journal = {Science translational medicine},
  year    = {2012},
  doi     = {10.1126/scitranslmed.3003771},
  pmid    = {22344463},
  url     = {https://doi.org/10.1126/scitranslmed.3003771}
}

@article{lott2012-22541290,
  author  = {Lott, I. T.},
  title   = {{Neurological phenotypes for Down syndrome across the life span}},
  journal = {Progress in brain research},
  year    = {2012},
  doi     = {10.1016/b978-0-444-54299-1.00006-6},
  pmid    = {22541290},
  url     = {https://doi.org/10.1016/b978-0-444-54299-1.00006-6}
}

@article{reinholdt2011-21953412,
  author  = {Reinholdt, L. G. and Ding, Y. and Gilbert, G. J. and Czechanski, A. and Solzak, J. P. and Roper, R. J. and Johnson, M. T. and Donahue, L. R. and others},
  title   = {{Molecular characterization of the translocation breakpoints in the Down syndrome mouse model Ts65Dn}},
  journal = {Mammalian genome : official journal of the International Mammalian Genome Society},
  year    = {2011},
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